Inflammation and Its Relationship to Insulin Resistance, Type 2 Diabetes Mellitus, and Endothelial Dysfunction

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

2002 • 18,132 citations

Inflammation and Atherosclerosis

2002 • 7,456 citations

Acute-Phase Proteins and Other Systemic Responses to Inflammation

1999 • 6,324 citations

C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women

2000 • 5,760 citations

C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

2001 • 4,289 citations

The cardiovascular health study: Design and rationale

1991 • 3,584 citations

Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events

2002 • 3,483 citations

NF-κB: Ten Years After

1996 • 3,008 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction

1999 • 2,478 citations

Elevated C-Reactive Protein Levels in Overweight and Obese Adults

1999 • 2,384 citations

Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome

2000 • 2,363 citations

Disseminated Intravascular Coagulation

1999 • 1,959 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

Primary Prevention of Coronary Heart Disease in Women through Diet and Lifestyle

2000 • 1,798 citations

Innate Immunity

2000 • 1,715 citations

Dietary Fiber, Glycemic Load, and Risk of Non—insulin-dependent Diabetes Mellitus in Women

1997 • 1,713 citations

Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid¹

1998 • 1,562 citations

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

2000 • 1,537 citations

Dietary Fiber, Glycemic Load, and Risk of NIDDM in Men

1997 • 1,442 citations

Effect of Dietary trans Fatty Acids on High-Density and Low-Density Lipoprotein Cholesterol Levels in Healthy Subjects

1990 • 1,434 citations

Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

1994 • 1,302 citations

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

1997 • 1,246 citations

A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women

2000 • 1,190 citations

Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction

1998 • 1,182 citations

Relationship Between Low Cardiorespiratory Fitness and Mortality in Normal-Weight, Overweight, and Obese Men

1999 • 1,178 citations

Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study

1999 • 1,054 citations

Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes

2002 • 1,053 citations

Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid

1998 • 1,009 citations

Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functions in Obese Women After Weight Loss Over One Year

2002 • 997 citations

Pravastatin and the Development of Diabetes Mellitus

2001 • 854 citations

C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages

2001 • 853 citations

Modulation of C-Reactive Protein–Mediated Monocyte Chemoattractant Protein-1 Induction in Human Endothelial Cells by Anti-Atherosclerosis Drugs

2001 • 839 citations

Relationship of C-Reactive Protein to Risk of Cardiovascular Disease in the Elderly

1997 • 838 citations

Dietary Patterns and Risk for Type 2 Diabetes Mellitus in U.S. Men

2002 • 818 citations

Polyunsaturated fatty acids, inflammation, and immunity

2001 • 765 citations

C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study

2002 • 717 citations

Low Cardiorespiratory Fitness and Physical Inactivity as Predictors of Mortality in Men with Type 2 Diabetes

2000 • 710 citations

Increased Glucose Transport–Phosphorylation and Muscle Glycogen Synthesis after Exercise Training in Insulin-Resistant Subjects

1996 • 700 citations

Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.

1999 • 657 citations

Increased Urinary Albumin Excretion, Endothelial Dysfunction, and Chronic Low-Grade Inflammation in Type 2 Diabetes

2002 • 653 citations

Body mass index, diabetes, and C-reactive protein among U.S. adults.

1999 • 650 citations

Novel Mechanism for Endothelial Dysfunction

1999 • 649 citations

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

2002 • 614 citations

Fundamentals of Endothelial Function for the Clinical Cardiologist

2002 • 608 citations

Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women

2002 • 600 citations

Relationship Between Insulin Resistance and an Endogenous Nitric Oxide Synthase Inhibitor

2002 • 590 citations

Low Grade Chronic Inflammation in Women with Polycystic Ovarian Syndrome

2001 • 589 citations

High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes

2002 • 560 citations

Nonsteroidal anti‐inflammatory drugs prevent early diabetic retinopathy via TNF‐α suppression

2002 • 556 citations

The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly

2001 • 549 citations

Prospective Study of C-Reactive Protein in Relation to the Development of Diabetes and Metabolic Syndrome in the Mexico City Diabetes Study

2002 • 521 citations

Improved glycemic control and lipid profile and normalized fibrinolytic activity on a low-glycemic index diet in type 2 diabetic patients.

1999 • 483 citations

The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes

2001 • 482 citations

Long-term Exercise and Atherogenic Activity of Blood Mononuclear Cells in Persons at Risk of Developing Ischemic Heart Disease

1999 • 436 citations

Diabetes and serum ferritin concentration among U.S. adults.

1999 • 423 citations

Clustering of Procoagulation, Inflammation, and Fibrinolysis Variables with Metabolic Factors in Insulin Resistance Syndrome

2000 • 422 citations

Mechanisms of TNF-α-induced insulin resistance

2009 • 412 citations

Low-Grade Systemic Inflammation in Overweight Children

2001 • 404 citations

Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability

2000 • 377 citations

Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women

1997 • 344 citations

Tumor necrosis factor alpha: a key component of the obesity-diabetes link

1994 • 343 citations

FATTY-ACID RATIOS IN FREE-LIVING AND DOMESTIC ANIMALS

1968 • 337 citations

Pleiotropic Effects of Statins: Lipid Reduction and Beyond

2002 • 316 citations

Retinal Arteriolar Narrowing and Risk of Diabetes Mellitus in Middle-aged Persons

2002 • 310 citations

Identifying the links between obesity, insulin resistance and β‐cell function: potential role of adipocyte‐derived cytokines in the pathogenesis of type 2 diabetes

2002 • 290 citations

Magnesium deficiency produces insulin resistance and increased thromboxane synthesis.

1993 • 278 citations

Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fasligand system in patients with chronic heart failure

2002 • 272 citations

Health effects of trans fatty acids

1997 • 271 citations

Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how?

2000 • 240 citations

Suppression of Nuclear Factor-κB and Stimulation of Inhibitor κB by Troglitazone: Evidence for an Anti-inflammatory Effect and a Potential Antiatherosclerotic Effect in the Obese

2001 • 225 citations

The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm

2002 • 223 citations

Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians

2002 • 218 citations

Relation Between Plasma Tumor Necrosis Factor-α and Insulin Sensitivity in Elderly Men With Non–Insulin-Dependent Diabetes Mellitus

1998 • 201 citations

Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells

2002 • 199 citations

Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome

1999 • 192 citations

Associations of Serum C-reactive Protein with Fasting Insulin, Glucose, and Glycosylated Hemoglobin : The Third National Health and Nutrition Examination Survey, 1988-1994

2002 • 171 citations

Markers of Inflammation and Cellular Adhesion Molecules in Relation to Insulin Resistance in Nondiabetic Elderly: The Rotterdam Study

2001 • 171 citations

Microalbuminuria and coronary heart disease in NIDDM: an incidence study.

1998 • 170 citations

Regulatory Role of Cytokines in Disseminated Intravascular Coagulation

2001 • 167 citations

Evolutionary adaptation of inflammatory immune responses in human beings

2000 • 156 citations

Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols

2000 • 148 citations

Fibrinogen, Other Putative Markers of Inflammation, and Weight Gain in Middle‐aged Adults—The ARIC Study

2000 • 148 citations

Leukocyte Count, Erythrocyte Sedimentation Rate, and Diabetes Incidence in a National Sample of US Adults

2002 • 147 citations

Elevated Serum Sialic Acid Concentration in NIDDM and Its Relationship to Blood Pressure and Retinopathy

1993 • 133 citations

Factor VIII and other hemostasis variables are related to incident diabetes in adults. The Atherosclerosis Risk in Communities (ARIC) Study.

1999 • 113 citations

White blood-cell count and the risk of impaired fasting glucose or Type II diabetes in middle-aged Japanese men

2002 • 109 citations

Relationship Between Insulin Resistance, Soluble Adhesion Molecules, and Mononuclear Cell Binding in Healthy Volunteers*

1999 • 107 citations

Tumor necrosis factor-[alpha ] inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells

2002 • 106 citations

Contribution of meat fat to dietary arachidonic acid

1998 • 106 citations

Low Grade Chronic Inflammation in Women with Polycystic Ovarian Syndrome

2001 • 105 citations

Insulin-Resistant Lipolysis in Abdominally Obese Hypertensive Individuals

1996 • 103 citations

Circulating Levels of Factor VII, Fibrinogen, and von Willebrand Factor and Features of Insulin Resistance in First-Degree Relatives of Patients With NIDDM

1996 • 102 citations

Effects of Exercise Training on Abdominal Obesity and Related Metabolic Complications

1996 • 101 citations

Fibrinogen and Factor VIII, but Not Factor VII, Are Associated With Measures of Subclinical Cardiovascular Disease in the Elderly

1995 • 96 citations

Prevalence of Clinical and Isolated Subclinical Cardiovascular Disease in Older Adults With Glucose Disorders

2001 • 94 citations

Suppression of Nuclear Factor- B and Stimulation of Inhibitor B by Troglitazone: Evidence for an Anti-inflammatory Effect and a Potential Antiatherosclerotic Effect in the Obese

2001 • 92 citations

Effects of disease modifying agents and dietary intervention on insulin resistance and dyslipidemia in inflammatory arthritis: a pilot study

2002 • 86 citations

Pleiotropic Effects of Statins: Lipid Reduction and Beyond

2002 • 72 citations

Gamma Globulin Levels Predict Type 2 Diabetes in the Pima Indian Population

2001 • 70 citations

Plasminogen activator inhibitor: a risk factor for myocardial infarction in diabetic patients.

1993 • 66 citations

Inhibition of insulin receptor signaling by TNF: Potential role in obesity and non-insulin-dependent diabetes mellitus

1996 • 66 citations

Serum Sialic Acid Concentration and Coronary Heart Disease in NIDDM

1995 • 63 citations

Markers of Inflammation and Cellular Adhesion Molecules in Relation to Insulin Resistance in Nondiabetic Elderly: The Rotterdam Study

2001 • 55 citations

Relationship Between Insulin Resistance, Soluble Adhesion Molecules, and Mononuclear Cell Binding in Healthy Volunteers

1999 • 55 citations

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

2002 • 50 citations

Messengers and mediators: interactions among lipids, eicosanoids, and cytokines

1993 • 44 citations

Total Sialic Acid and Associated Elements of the Metabolic Syndrome in Women With and Without Previous Gestational Diabetes

2002 • 44 citations

The association between physical activity, physical fitness, and type 2 diabetes mellitus

2000 • 41 citations

Associations between White Blood Cell Count and Features of the Metabolic Syndrome in Japanese Male Office Workers.

2002 • 41 citations

White blood cell count and clustered features of metabolic syndrome in Japanese male office workers

2002 • 40 citations

Trans, n‐3, and n‐6 fatty acids in canadian human milk

1996 • 37 citations

Plasminogen Activator Inhibitor (PAI-1) Activity is Elevated in Asian and Caucasian Subjects with Non-insulin-dependent (Type 2) Diabetes but not in Those with Impaired Glucose Tolerance (IGT) or Non-diabetic Asians

1996 • 27 citations

Hyperglycaemic siblings of Type II (non-insulin-dependent) diabetic patients have increased PAI-1, central obesity and insulin resistance compared with their paired normoglycaemic sibling

2002 • 16 citations

Ethnic Differences in Correlates of Microalbuminuria in NIDDM: The role of the acute-phase response

1998 • 12 citations