Potential role of platelets in the pathogenesis of tumor metastasis

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls

1979 • 1,158 citations

Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation.

1974 • 775 citations

Antimetastatic effects associated with platelet reduction.

1968 • 695 citations

The platelet-derived growth factor

1978 • 649 citations

The significance of hematogenous tumor cell clumps in the metastatic process.

1976 • 568 citations

Culture of vascular endothelium.

1976 • 532 citations

Platelet—tumor‐cell interactions in mice. The role of platelets in the spread of malignant disease

1973 • 447 citations

DIPYRIDAMOLE AND OTHER PHOSPHODIESTERASE INHIBITORS ACT AS ANTITHROMBOTIC AGENTS BY POTENTIATING ENDOGENOUS PROSTACYCLIN

1978 • 392 citations

Prostacyclin: A Potent Antimetastatic Agent

1981 • 335 citations

Prostaglandins and cancer: A review of tumor initiation through tumor metastasis

1981 • 273 citations

Correlation between spontaneous metastatic potential, platelet-aggregating activity of cell surface extracts, and cell surface sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma cell line.

1980 • 192 citations

Electron microscopic observations on formation of pulmonary metastases

1975 • 137 citations

Mechanisms of metastasis

1979 • 128 citations

Characterization of Human Platelet Vascular Permeability-Enhancing Activity

1972 • 128 citations

REMOVAL OF SIALIC ACID FROM THE CELL COAT IN TUMOR CELLS AND VASCULAR ENDOTHELLUM, AND ITS EFFECTS ON METASTASIS

1962 • 128 citations

Inhibition of the platelet-aggregating activity of two human adenocarcinomas of the colon and an anaplastic murine tumor with a specific thrombin inhibitor, dansylarginine N-(3-ethyl-1,5-pentanediyl)amide.

1981 • 95 citations

Inhibition of tumor cell metastasis by modulation of the vascular prostacyclin/thromboxane A2 system

1983 • 93 citations

Inhibition of Metastatic Spread by I.C.R.F. 159: Selective Deletion of a Malignant Characteristic

1970 • 90 citations

Tumor Cell-Platelet Aggregation: Induced by Cathepsin B-Like Proteinase and Inhibited by Prostacyclin

1982 • 83 citations

Mode of action of dipyridamole on human platelets

1979 • 76 citations

Aggregation of platelets and cell membrane vesiculation by rat cells transformed in vitro by Rous sarcoma virus.

1978 • 74 citations

EXPERIMENTAL STUDIES OF THE INTRAVASCULAR DISSEMINATION OF ASCITIC V2 CARCINOMA CELLS IN THE RABBIT, WITH SPECIAL REFERENCE TO FIBRINOGEN AND FIBRINOLYTIC AGENTS.

1964 • 69 citations

Extraction and characterization of a platelet-aggregating material from SV40-transformed mouse 3T3 fibroblasts.

1979 • 69 citations

Thromboxanes and prostacyclin: Positive and negative modulators of tumor growth

1981 • 65 citations

The interaction of platelets, tumor cells, and vascular subendothelium.

1980 • 57 citations

The influence of host immunity on the arrest of circulating cancer cells, and its modification by neuraminidase

1974 • 56 citations

The influence of platelet aggregation inhibitors on metastasis formation in mice (3LL)

1976 • 52 citations

Experimental studies on histogenesis of blood-borne metastases.

1955 • 47 citations

Human platelet basic protein associated with antiheparin and mitogenic activities: purification and partial characterization.

1980 • 39 citations

Tumor necrosis and cell detachment

1977 • 38 citations

Control of tumor growth and metastasis with prostacyclin and thromboxane synthetase inhibitors: evidence for a new antitumor and antimetastatic agent (BAY g 6575).

1982 • 35 citations

Dipyridamole and Aspirin in Relation to Platelet Aggregation and Vessel Wall Prostaglandin Generation

1982 • 24 citations

Selective antimetastatic treatment—current status and future prospects

1974 • 23 citations

Studies on platelet aggregation inhibitors in vivo. VIII. Effect of pentoxifylline on spontaneous tumor metastasis.

1979 • 22 citations

Effects of trypsin on the platelet-aggregating activity of mouse tumor cells

1977 • 20 citations

Effect of dipyridamole of prostaglandin generation by human platelets and vessel walls

1982 • 20 citations

Observations on the effect of neuraminidase on the distribution of intravenously injected walker tumor cells in rats

1974 • 19 citations

Arterial prostacyclin generation is decreased in patients with malignant bone tumors

1983 • 12 citations

Enhanced tumor growth in vivo by a factor in human platelets and rat liver.

1982 • 11 citations

Plasma concentrations of thromboxane and prostacyclin metabolites in patients with bone tumors.

1985 • 5 citations

The Intravascular Implantation of Rat Tumors.

1913 • 4 citations