Photoreceptor specific guanylate cyclases in vertebrate phototransduction.

Amplification and kinetics of the activation steps in phototransduction

1993 • 645 citations

Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions

1988 • 634 citations

Adaptation in Vertebrate Photoreceptors

2001 • 551 citations

Retinal–specific guanylate cyclase gene mutations in Leber's congenital amaurosis

1996 • 442 citations

RGS9, a GTPase Accelerator for Phototransduction

1998 • 383 citations

Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein

1994 • 364 citations

Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease

1999 • 351 citations

The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator

1994 • 338 citations

Phototransduction mechanism in retinal rods and cones. The Friedenwald Lecture.

1994 • 335 citations

Molecular mechanisms of vertebrate photoreceptor light adaptation

1999 • 333 citations

Cloning, Sequencing, and Expression of a 24-kDa Ca2+-binding Protein Activating Photoreceptor Guanylyl Cyclase

1995 • 307 citations

A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway

1997 • 302 citations

The 220-kDa Rim Protein of Retinal Rod Outer Segments Is a Member of the ABC Transporter Superfamily

1997 • 297 citations

The calcium feedback signal in the phototransduction cascade of vertebrate rods

1994 • 290 citations

A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons.

1995 • 270 citations

Catalytic mechanism of the adenylyl and guanylyl cyclases: Modeling and mutational analysis

1997 • 257 citations

Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods.

1994 • 247 citations

Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2.

1995 • 239 citations

Regulation of sensitivity in vertebrate rod photoreceptors by calcium

1996 • 237 citations

Two membrane forms of guanylyl cyclase found in the eye.

1995 • 237 citations

A 240 kDa protein represents the complete β subunit of the cyclic nucleotide-gated channel from rod photoreceptor

1995 • 235 citations

Mutations in the Retinal Guanylate Cyclase (RETGC-1) Gene in Dominant Cone-Rod Dystrophy

1998 • 225 citations

Molecular cloning of a retina-specific membrane guanylyl cyclase

1992 • 220 citations

Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase

1998 • 213 citations

Control of light‐sensitive current in salamander rods.

1988 • 207 citations

Guanylyl Cyclase Activating Protein

1995 • 203 citations

Role of cGMP and Ca2+ in Vertebrate Photoreceptor Excitation and Adaptation

1992 • 198 citations

An Optimized Method for In Situ Hybridization with Signal Amplification That Allows the Detection of Rare mRNAs

1999 • 177 citations

Photoreceptor membrane proteins, phototransduction, and retinal degenerative diseases. The Friedenwald Lecture.

1998 • 173 citations

Photoreceptor Guanylate Cyclases: A Review

1997 • 165 citations

A cGMP-signaling pathway in a subset of olfactory sensory neurons

2000 • 164 citations

Purification and identification of photoreceptor guanylate cyclase

1991 • 162 citations

Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors

1999 • 158 citations

Phosphorylation of the Kinase Homology Domain Is Essential for Activation of the A-Type Natriuretic Peptide Receptor

1998 • 153 citations

Ca2+-binding proteins in the retina: Structure, function, and the etiology of human visual diseases

2000 • 153 citations

Two Eye Guanylyl Cyclases Are Expressed in the Same Photoreceptor Cells and Form Homomers in Preference to Heteromers

1997 • 141 citations

The Membrane Guanylyl Cyclase, Retinal Guanylyl Cyclase-1, Is Activated through Its Intracellular Domain

1996 • 139 citations

Guanylate cyclase of isolated bovine retinal rod axonemes

1979 • 137 citations

Molecular Characterization of a Third Member of the Guanylyl Cyclase-activating Protein Subfamily

1999 • 135 citations

Structural and functional characterization of the rod outer segment membrane guanylate cyclase

1994 • 132 citations

Ultrastructural localization of retinal guanylate cyclase in human and monkey retinas

1994 • 131 citations

Calcium Binding, but Not a Calcium-Myristoyl Switch, Controls the Ability of Guanylyl Cyclase-activating Protein GCAP-2 to Regulate Photoreceptor Guanylyl Cyclase

1997 • 130 citations

Functional Characterization of a Guanylyl Cyclase-activating Protein from Vertebrate Rods

1996 • 126 citations

Calcium Modulation of Bovine Photoreceptor Guanylate Cyclase

1996 • 100 citations

Characterization of guanylate cyclase activity in single retinal rod outer segments

1995 • 99 citations

Inactivation of EF-hands Makes GCAP-2 (p24) a Constitutive Activator of Photoreceptor Guanylyl Cyclase by Preventing a Ca2+-induced “Activator-to-Inhibitor” Transition

1996 • 95 citations

Biochemical analysis of a dimerization domain mutation in RetGC-1 associated with dominant cone–rod dystrophy

1999 • 95 citations

Autosomal dominant cone–rod retinal dystrophy (CORD6) from heterozygous mutation of GUCY2D , which encodes retinal guanylate cyclase 1 1The authors have no proprietary interests in the materials mentioned in the study.

2000 • 94 citations

Guanylate cyclase from bovine rod outer segments: solubilization, partial purification, and regulation by inorganic pyrophosphate

1990 • 89 citations

Polymorphism in purified guanylate cyclase from vertebrate rod photoreceptors.

1991 • 78 citations

Cloning and expression of an ATP-regulated human retina C-type natriuretic factor receptor guanylate cyclase

1993 • 77 citations

Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene.

1994 • 75 citations

The adenylyl and guanylyl cyclase superfamily

1998 • 74 citations

Regions in vertebrate photoreceptor guanylyl cyclase ROS‐GC1 involved in Ca²⁺‐dependent regulation by guanylyl cyclase‐activating protein GCAP‐1

1999 • 73 citations

Stereochemical course of the reaction catalyzed by guanylate cyclase from bovine retinal rod outer segments.

1990 • 70 citations

Functional Consequences of a Rod Outer Segment Membrane Guanylate Cyclase (ROS-GC1) Gene Mutation Linked with Leber's Congenital Amaurosis

1998 • 68 citations

Structural and Biochemical Identity of Retinal Rod Outer Segment Membrane Guanylate Cyclase

1993 • 64 citations

Activation of Retinal Guanylyl Cyclase-1 by Ca2+-binding Proteins Involves Its Dimerization

1999 • 64 citations

The bovine rod outer segment guanylate cyclase, ROS-GC, is present in both outer segment and synaptic layers of the retina

1995 • 56 citations

Identification of a Guanylyl Cyclase-Activating Protein-Binding Site within the Catalytic Domain of Retinal Guanylyl Cyclase1

1999 • 55 citations

Differences in transduction between rod and cone photoreceptors: an exploration of the role of calcium homeostasis

1994 • 54 citations

Regulation of cGMP levels by guanylate cyclase in truncated frog rod outer segments.

1989 • 51 citations

Nucleotide Inhibitors and Activators of Retinal Guanylyl Cyclase

1994 • 51 citations

Rod Outer Segment Membrane Guanylate Cyclase Type 1-Linked Stimulatory and Inhibitory Calcium Signaling Systems in the Pineal Gland: Biochemical, Molecular, and Immunohistochemical Evidence

2000 • 50 citations

Structural and Functional Characterization of a Second Subfamily Member of the Calcium-Modulated Bovine Rod Outer Segment Membrane Guanylate Cyclase, ROS-GC2

1997 • 49 citations

The Photoreceptor Guanylate Cyclase Is an Autophosphorylating Protein Kinase

1996 • 47 citations

Guanylate‐cyclase‐inhibitory protein is a frog retinal Ca²⁺‐binding protein related to mammalian guanylate‐cyclase‐activating proteins

1998 • 45 citations

Identification of a Domain in Guanylyl Cyclase-activating Protein 1 That Interacts with a Complex of Guanylyl Cyclase and Tubulin in Photoreceptors

1999 • 44 citations

Mutations in the Rod Outer Segment Membrane Guanylate Cyclase in a Cone−Rod Dystrophy Cause Defects in Calcium Signaling

1999 • 42 citations

Third calcium-modulated rod outer segment membrane guanylate cyclase transduction mechanism.

1998 • 38 citations

Impairment of the Rod Outer Segment Membrane Guanylate Cyclase Dimerization in A Cone−Rod Dystrophy Results in Defective Calcium Signaling

2000 • 37 citations

Domain-Specific Stabilization of Photoreceptor Membrane Guanylyl Cyclase by Adenine Nucleotides and Guanylyl Cyclase Activating Proteins (GCAPs)

1997 • 35 citations

A Possible Role of RGS9 in Phototransduction

1998 • 34 citations

Activation by PKC of the Ca2+-sensitive guanylyl cyclase in bovine retinal rod outer segments measured with optical assays

1995 • 32 citations

Negatively Calcium-Modulated Membrane Guanylate Cyclase Signaling System in the Rat Olfactory Bulb

2001 • 31 citations

Expression of guanylate cyclase-A mRNA in the rat retina: Detection using polymerase chain reaction

1992 • 31 citations

Three dimensional atomic model and experimental validation for the ATP-Regulated Module (ARM) of the atrial natriuretic factor receptor guanylate cyclase.

2000 • 29 citations

Distribution of guanylate cyclase within photoreceptor outer segments

1996 • 27 citations

Phosphorylation of recoverin, the calcium‐sensitive activator of photoreceptor guanylyl cyclase

1991 • 27 citations

Calcium Modulated Signaling Site in Type 2 Rod Outer Segment Membrane Guanylate Cyclase (ROS-GC2)

1998 • 25 citations

Interactions of nucleotide analogs with rod outer segment guanylate cyclase

1991 • 23 citations

Modulation of the Calcium Sensitivity of Bovine Retinal Rod Outer Segment Guanylyl Cyclase by Sodium Ions and Protein Kinase A

1996 • 22 citations

Bovine retinal rod guanyl cyclase represents a new N‐glycosylated subtype of membrane‐bound guanyl cyclases

1994 • 21 citations

Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase from Bovine Eye: High Calmodulin Affinity Isozyme Immunologically Related to the Brain 60-kDa Isozyme

1997 • 20 citations

Three dimensional atomic model and experimental validation for the ATP-Regulated Module (ARM) of the atrial natriuretic factor receptor guanylate cyclase.

2001 • 17 citations

Control of photoreceptor proteins by Ca2+

1995 • 17 citations

Distinct inhibitory ATP-regulated modulatory domain (ARMi) in membrane guanylate cyclases

1996 • 16 citations

Membrane guanylate cyclase signal transduction system.

1997 • 13 citations