Expression and properties of two distinct classes of the phorbol ester receptor family, four conventional protein kinase C types, and a novel protein kinase C.

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

The structure, expression, and properties of additional members of the protein kinase C family.

1988 • 706 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

Tissue-specific expression of three distinct types of rabbit protein kinase C

1987 • 469 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family

1988 • 414 citations

Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 389 citations

Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels

1984 • 334 citations

Expression and Properties of Two Types of Protein Kinase C: Alternative Splicing from a Single Gene

1987 • 317 citations

Competitive inhibition by diacylglycerol of specific phorbol ester binding.

1984 • 306 citations

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

1983 • 292 citations

Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP.

1985 • 274 citations

Mode of Activation and Kinetic Properties of Three Distinct Forms of Protein Kinase C from Rat Brain1

1988 • 225 citations

Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells.

1985 • 218 citations

Two types of complementary DNAs of rat brain protein kinase C

1986 • 212 citations

Identification of the structures of multiple subspecies of protein kinase C expressed in rat brain

1987 • 202 citations

Purification and characterization of three types of protein kinase C from rabbit brain cytosol.

1987 • 168 citations

Identification of high-affinity phorbol ester receptor in cytosol of EL4 thymoma cells: requirement for calcium, magnesium, and phospholipids.

1983 • 157 citations

Association of protein kinase C with phospholipid vesicles

1987 • 149 citations

Protein Kinase C Located in Rat Liver Nuclei

1989 • 145 citations

Factors influencing chelator-stable, detergent-extractable, phorbol diester-induced membrane association of protein kinase C. Differences between Ca2+-induced and phorbol ester-stabilized membrane bindings of protein kinase C.

1986 • 144 citations

The lipid binding, regulatory domain of protein kinase C. A 32-kDa fragment contains the calcium- and phosphatidylserine-dependent phorbol diester binding activity.

1986 • 140 citations

Protein kinase C translocates from cytosol to membrane upon hormone activation: Effects of thyrotropin-releasing hormone in GH3 cells

1985 • 119 citations

Immunochemical characterization of protein kinase C in rat liver nuclei and subnuclear fractions

1987 • 108 citations

Three activators of protein kinase C, bryostatins, dioleins, and phorbol esters, show differing specificities of action on GH4 pituitary cells.

1986 • 108 citations

Increases in Intracellular Ca2+ Regulate the Binding of [3H]Phorbol 12,13-Dibutyrate to Intact 1321N1 Astrocytoma Cells

1989 • 97 citations

Primary structures of human protein kinase C βI and βII differ only in their C‐terminal sequences

1987 • 97 citations

Quantitative characterization of hormone receptors

1980 • 91 citations

Rapid Assay of Binding of Tumor-Promoting Phorbol Esters to Protein Kinase C1

1986 • 84 citations

Enzymatic Properties of a Novel Phorbol Ester Receptor/Protein Kinase, nPKC1

1989 • 80 citations

A fourth type of rabbit protein kinase C

1988 • 80 citations

Kinetics and subcellular localization of specific [3H]phorbol 12, 13-dibutyrate binding by mouse brain.

1981 • 77 citations

Conversion of protein kinase C from a Ca2+-dependent to an independent form of phorbol ester-binding protein by digestion with trypsim

1986 • 74 citations

Influence of calcium on the subcellular distribution of protein kinase C in human neutrophils

1989 • 62 citations

Disparate effects of activators of protein kinase C on HL-60 promyelocytic leukemia cell differentiation.

1987 • 60 citations

Measurement of phorbol ester receptors in intact cells and subcellular fractions

1987 • 51 citations

Solubilization, purification, and reconstitution of a phorbol ester receptor from the particulate protein fraction of mouse brain.

1983 • 50 citations

Thyrotropin-Releasing Hormone and Epidermal Growth Factor Stimulate Prolactin Synthesis by a Pathway(s) that Differs from that Used by Phorbol Esters: Dissociation of Actions by Calcium Dependency and Additivity*

1985 • 43 citations

Activation of interleukin-2 receptor gene by Forskolin and cyclic AMP analogues

1987 • 23 citations

Nucleotide sequence of the 3' portion of a human gene for protein kinase CβI/βII

1987 • 22 citations