The epidermal growth factor receptor tyrosine kinase in liver epithelial cells

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

Epidermal Growth Factor

1979 • 2,964 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Receptor-mediated endocytosis

1985 • 577 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver.

1980 • 451 citations

A diploid epithelial cell line from normal adult rat liver with phenotypic properties of ?oval? cells*1

1984 • 381 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts.

1984 • 357 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.

1984 • 295 citations

Molecular mechanism of mitogen action: Processing of receptor induced by epidermal growth factor

1978 • 271 citations

Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics.

1984 • 265 citations

Hormone receptor topology and dynamics: Morphological analysis using ferritin-labeled epidermal growth factor

1979 • 254 citations

Regulation of Cell Proliferation by Epidermal Growth Factor

1983 • 235 citations

Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent.

1988 • 228 citations

Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.

1986 • 217 citations

A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction.

1988 • 215 citations

Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding.

1987 • 209 citations

Epidermal growth factor (EGF) stimulates EGF receptor synthesis.

1986 • 190 citations

Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells.

1986 • 148 citations

Biphasic effects of type beta transforming growth factor on epidermal growth factor receptors in NRK fibroblasts. Functional consequences for epidermal growth factor-stimulated mitosis.

1985 • 132 citations

Internalization of functional epidermal growth factor:receptor/kinase complexes in A-431 cells.

1985 • 128 citations

Growth factor control of epidermal growth factor receptor kinase activity via an intramolecular mechanism.

1988 • 98 citations

Fluorescent antibody techniques and their applications

1977 • 90 citations

Epidermal growth factor receptor kinase translocation and activation in vivo.

1986 • 81 citations

Epidermal growth factor (EGF) and hormones stimulate phosphoinositide hydrolysis and increase EGF receptor protein synthesis and mRNA levels in rat liver epithelial cells. Evidence for protein kinase C-dependent and -independent pathways.

1988 • 76 citations

Identification of pp120, an endogenous substrate for the hepatocyte insulin receptor tyrosine kinase, as an integral membrane glycoprotein of the bile canalicular domain.

1988 • 66 citations

Kinetics and regulation of the tyrosine phosphorylation of epidermal growth factor receptor in intact A431 cells.

1988 • 51 citations

Cross-linking of epidermal growth factor receptors in intact cells: detection of initial stages of receptor clustering and determination of molecular weight of high-affinity receptors

1986 • 45 citations

Characterization of distinct tyrosine-specific protein kinases in B and T lymphocytes.

1985 • 41 citations

Dexamethasone-Induced Changes in Phosphorylation of the Insulin and Epidermal Growth Factor Receptors and Their Substrates in Intact Rat Hepatocytes*

1988 • 30 citations

The effects of epidermal growth factor and the state of confluence on enzymatic activities of cultured rat liver epithelial cells

1986 • 28 citations