Hormonal control of interacting promoters introduced into cells by retroviruses

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes

1982 • 1,338 citations

Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice

1983 • 699 citations

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice

1985 • 663 citations

Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells.

1986 • 533 citations

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

1984 • 527 citations

Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues

1984 • 486 citations

Progress Toward Human Gene Therapy

1989 • 484 citations

Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism

1984 • 440 citations

Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.

1986 • 427 citations

cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei.

1982 • 410 citations

Retrovirus Packaging Cells

1990 • 388 citations

Effect of internal viral sequences on the utility of retroviral vectors

1987 • 351 citations

Chromosomal position and activation of retroviral genomes inserted into the germ line of mice

1981 • 344 citations

Gene Expression in Mice After High Efficiency Retroviral-Mediated Gene Transfer

1985 • 281 citations

Highly preferred targets for retrovirus integration

1988 • 262 citations

Six distinct nuclear factors interact with the 75-base-pair repeat of the Moloney murine leukemia virus enhancer.

1987 • 259 citations

Expression of human class II major histocompatibility complex antigens using retrovirus vectors.

1987 • 257 citations

Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites

1987 • 248 citations

Tissue-specific expression and dietary regulation of a chimeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice.

1988 • 243 citations

Chromosomal position or virus mutation permits retrovirus expression in embryonal carcinoma cells

1986 • 236 citations

Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells

1983 • 214 citations

Cloning and nucleotide sequencing of the bovine growth hormone gene

1982 • 214 citations

Acceptor sites for retroviral integrations map near DNase I-hypersensitive sites in chromatin

1986 • 212 citations

The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP).

1990 • 210 citations

The Application of Bone Marrow Transplantation to the Treatment of Genetic Diseases

1986 • 207 citations

An alternative approach to somatic cell gene therapy.

1988 • 198 citations

Isolation and characterization of the gene coding for cytosolic phosphoenolpyruvate carboxykinase (GTP) from the rat.

1983 • 198 citations

Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo.

1986 • 194 citations

Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector.

1989 • 192 citations

Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells.

1984 • 155 citations

Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasone.

1987 • 155 citations

Quantitative analysis of gene suppression in integrated retrovirus vectors.

1986 • 155 citations

Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit.

1988 • 155 citations

A majority of mice show long-term expression of a human beta-globin gene after retrovirus transfer into hematopoietic stem cells.

1989 • 153 citations

Regulated expression of a complete human beta-globin gene encoded by a transmissible retrovirus vector.

1987 • 153 citations

Identification of multiple protein binding domains in the promoter-regulatory region of the phosphoenolpyruvate carboxykinase (GTP) gene

1989 • 152 citations

Retrovirus-mediated transduction of adult hepatocytes.

1988 • 138 citations

Implantation of Genetically Engineered Fibroblasts into Mice: Implications for Gene Therapy

1987 • 138 citations

Expression of retroviral vectors in transgenic mice obtained by embryo infection.

1987 • 128 citations

Gene expression from transcriptionally disabled retroviral vectors.

1987 • 120 citations

Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene.

1988 • 113 citations

Functional analysis of a retroviral host-range mutant: altered long terminal repeat sequences allow expression in embryonal carcinoma cells.

1987 • 113 citations

Comparison of expression in hemopoietic cells by retroviral vectors carrying two genes

1988 • 111 citations

Isolation of cDNA clones coding for rat tyrosine aminotransferase.

1982 • 111 citations

Hepatic gene transfer in animals using retroviruses containing the promoter from the gene for phosphoenolpyruvate carboxykinase.

1990 • 106 citations

Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. I. Multiple hormone regulatory elements and the effects of enhancers.

1986 • 103 citations

Chromosomal position effects determine transcriptional potential of integrated mammary tumor virus DNA

1982 • 101 citations

Infectious and Selectable Retrovirus Containing an Inducible Rat Growth Hormone Minigene

1984 • 99 citations

Mechanism of suppression of the long terminal repeat of Moloney leukemia virus in mouse embryonal carcinoma cells.

1989 • 99 citations

Human purine nucleoside phosphorylase and adenosine deaminase: gene transfer into cultured cells and murine hematopoietic stem cells by using recombinant amphotropic retroviruses.

1987 • 97 citations

Retroviral gene transfer into primary hepatocytes: implications for genetic therapy of liver-specific functions.

1987 • 95 citations

Transfer of genes into embryonal carcinoma cells by retrovirus infection: efficient expression from an internal promoter.

1985 • 94 citations

Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes.

1987 • 84 citations

Two distinct sequence elements mediate retroviral gene expression in embryonal carcinoma cells

1987 • 73 citations

Retroviral-mediated gene transfer and expression of human phenylalanine hydroxylase in primary mouse hepatocytes.

1988 • 71 citations

Cell-specified expression of a selectable hybrid gene.

1984 • 69 citations

Production of glycosylated physiologically "normal" human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a retroviral vector.

1987 • 68 citations

Proviral sequences that restrict retroviral expression in mouse embryonal carcinoma cells.

1987 • 68 citations

Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitro.

1988 • 57 citations

Generation of glucocorticoid-responsive Moloney murine leukemia virus by insertion of regulatory sequences from murine mammary tumor virus into the long terminal repeat

1985 • 56 citations

Integration-specific retrovirus expression in embryonal carcinoma cells.

1984 • 53 citations

Expression of the Rat L-type Pyruvate Kinase Gene from Its Dual Erythroid- and Liver-specific Promoter in Transgenic Mice

1989 • 51 citations

Variable stability of a selectable provirus after retroviral vector gene transfer into human cells.

1986 • 47 citations

Isolation of thymidine kinase-deficient rat hepatoma cells by selection with bromodeoxyuridine, Hoechst 33258, and visible light

1984 • 47 citations

Hormonal regulation of chimeric genes containing the phosphoenolpyruvate carboxykinase promoter regulatory region in hepatoma cells infected by murine retroviruses.

1988 • 30 citations

Construction of a Defective Retrovirus Containing the Human Hypoxanthine Phosphoribosyltransferase cDNA and its Expression in Cultured Cells and Mouse Bone Marrow

1987 • 26 citations

Phosphoenolpyruvate carboxykinase. II. Hormonal controls

1973 • 22 citations

Retroviral vector gene expression in F9 embryonal carcinoma cells

1987 • 14 citations

Regulation of chimeric phosphoenolpyruvate carboxykinase genes by the trans-dominant locus TSE1.

1990 • 9 citations