Cross-linking of Fc gamma receptor to surface immunoglobulin on B cells provides an inhibitory signal that closes the plasma membrane calcium channel

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release

1991 • 843 citations

Surface Density of Calcium Ions and Calcium Spikes in the Barnacle Muscle Fiber Membrane

1967 • 445 citations

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

1991 • 433 citations

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

1986 • 369 citations

Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger

1993 • 363 citations

Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor

1990 • 346 citations

Generation of Calcium Oscillations in Fibroblasts by Positive Feedback Between Calcium and IP ₃

1991 • 317 citations

Agonists stimulate divalent cation channels in the plasma membrane of human platelets

1985 • 303 citations

Cross-linking of B lymphocyte Fc gamma receptors and membrane immunoglobulin inhibits anti-immunoglobulin-induced blastogenesis.

1984 • 292 citations

Molecular Mechanisms of Transmembrane Signaling in B Lymphocytes

1987 • 279 citations

The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets.

1987 • 245 citations

Inositol trisphosphate receptor: phosphorylation by protein kinase C and calcium calmodulin-dependent protein kinases in reconstituted lipid vesicles.

1991 • 233 citations

Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin.

1990 • 225 citations

The Src family of tyrosine protein kinases in hemopoietic signal transduction

1992 • 221 citations

IP ₃ Receptor: Localization to Plasma Membrane of T Cells and Cocapping with the T Cell Receptor

1992 • 213 citations

Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.

1991 • 205 citations

B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase

1991 • 204 citations

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

1993 • 198 citations

Crosslinking of surface immunoglobulin and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via the antigen receptors.

1985 • 198 citations

Fc-dependent inhibition of mouse B cell activation by whole anti-mu antibodies.

1983 • 187 citations

Protein kinase C and T cell activation

1990 • 183 citations

The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release.

1991 • 163 citations

Regulation of Human B-Cell Activation and Adhesion

1991 • 161 citations

Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes.

1992 • 128 citations

Receptor‐mediated calcium entry

1990 • 127 citations

Control of B-lymphocyte function. I. Inactivation of mitogenesis by interactions with surface immunoglobulin and Fc-receptor molecules.

1976 • 123 citations

Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes.

1993 • 117 citations

Tyrosine phosphorylation of phospholipase C-gamma 2 upon cross-linking of membrane Ig on murine B lymphocytes.

1992 • 109 citations

Activation and proliferation signals in mouse B cells VIII. Induction of DNA synthesis in B cells by a combination of calcium ionophores and phorbol myristate acetate

1986 • 104 citations

The Fc‐Receptor: Its Role in the Transmission of Differentiation Signals¹

1980 • 94 citations

Stimulation of tyrosine phosphorylation and calcium mobilization by Fc gamma receptor cross-linking. Regulation by the phosphotyrosine phosphatase CD45.

1993 • 92 citations

Crosslinkage of B lymphocyte surface immunoglobulin by anti-Ig or antigen induces prolonged oscillation of intracellular ionized calcium.

1987 • 82 citations

The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin cross-linkage to the Fc gamma receptor.

1987 • 71 citations

Surface immunoglobulin crosslinking activates a tyrosine kinase pathway in B cells that is independent of protein kinase C.

1991 • 65 citations

Synergistic action of A23187 and phorbol ester on human B cell activation.

1985 • 60 citations

Fc receptor phosphorylation during receptor-mediated control of B-cell activation

1990 • 48 citations

Activation and proliferation signals in mouse B cells. III. Intact (IGG) anti-immunoglobulin antibodies activate B cells but inhibit induction of DNA synthesis.

1984 • 48 citations

Co‐cross‐linking of surface immunoglobulin Fcγ receptors on B lymphocytes uncouples the antigen receptors from their associated G protein

1989 • 47 citations

Antigen-antibody complexes bound to B-lymphocyte Fcγ receptors regulate B-lymphocyte differentiation

1985 • 47 citations

Signal Transduction Pathways Involved in B‐Cell Induction

1993 • 45 citations

Cooperativity between B lymphocyte membrane molecules: independent ligand occupancy and cross-linking of antigen receptors and Fc gamma receptors down-regulates B lymphocyte function.

1986 • 41 citations

Increased intracellular Ca2+ induces Ca2+ influx in human T lymphocytes.

1993 • 38 citations

Rapid signaling to B cells by antigen-specific T cells requires CD18/CD54 interaction.

1991 • 29 citations

Independent ligand occupancy and cross-linking of surface Ig and Fcγ receptors downregulates B-lymphocyte function. evaluation in various B-lymphocyte populations

1986 • 24 citations

Antigen-induced Ca2+ signaling and desensitization in B cells.

1990 • 16 citations

Antigen-induced Fc receptor-dependent and -independent B cell desensitization. An elevation in [Ca2+]i is not sufficient and protein kinase C activation is not required for these pathways of surface IgM-mediated desensitization.

1991 • 9 citations