Actin' up: RhoB in cancer and apoptosis

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Genomic analysis of metastasis reveals an essential role for RhoC

2000 • 1,449 citations

Blocking Oncogenic Ras Signaling for Cancer Therapy

2001 • 837 citations

Differential Localization of Rho Gtpases in Live Cells

2001 • 686 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

1997 • 605 citations

Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development

1999 • 538 citations

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1995 • 533 citations

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

1999 • 440 citations

Intracellular localization of the P21rho proteins.

1992 • 382 citations

RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype.

2000 • 318 citations

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies

2000 • 284 citations

Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas

1998 • 278 citations

Rho Proteins: Linking Signaling with Membrane Trafficking

2001 • 274 citations

Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?

1997 • 271 citations

Critical role of Rho in cell transformation by oncogenic Ras.

1995 • 256 citations

Cell Growth Inhibition by Farnesyltransferase Inhibitors Is Mediated by Gain of Geranylgeranylated RhoB

1999 • 255 citations

A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype.

1999 • 251 citations

The Phosphoinositide 3-OH Kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis

2000 • 244 citations

A role for rhoB in the delamination of neural crest cells from the dorsal neural tube

1998 • 244 citations

Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor κB by the Rho Family of GTPases

1998 • 233 citations

Evidence that Farnesyltransferase Inhibitors Suppress Ras Transformation by Interfering with Rho Activity

1995 • 220 citations

Farnesyltransferase Inhibitors Alter the Prenylation and Growth-stimulating Function of RhoB

1997 • 214 citations

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho

1998 • 214 citations

The γ-subunit of the coatomer complex binds Cdc42 to mediate transformation

2000 • 211 citations

RhoB Is Dispensable for Mouse Development, but It Modifies Susceptibility to Tumor Formation as Well as Cell Adhesion and Growth Factor Signaling in Transformed Cells

2001 • 208 citations

Regulation of epidermal growth factor receptor traffic by the small GTPase RhoB

1999 • 199 citations

Farnesyltransferase Inhibition Causes Morphological Reversion of ras-Transformed Cells by a Complex Mechanism That Involves Regulation of the Actin Cytoskeleton

1994 • 197 citations

Both Farnesylated and Geranylgeranylated RhoB Inhibit Malignant Transformation and Suppress Human Tumor Growth in Nude Mice

2000 • 192 citations

Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.

1998 • 191 citations

A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast

2001 • 163 citations

The ras-Related Gene rhoB Is an Immediate-Early Gene Inducible by v-Fps, Epidermal Growth Factor, and Platelet-Derived Growth Factor in Rat Fibroblasts

1991 • 162 citations

Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors.

1999 • 159 citations

RhoB Alteration Is Necessary for Apoptotic and Antineoplastic Responses to Farnesyltransferase Inhibitors

2000 • 158 citations

The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts.

1996 • 150 citations

The Ras-related Small GTP-binding Protein RhoB Is Immediate-early Inducible by DNA Damaging Treatments

1995 • 149 citations

RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

2001 • 146 citations

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton.

1994 • 142 citations

GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.

1997 • 139 citations

Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects

2000 • 138 citations

The Farnesyltransferase Inhibitor, FTI-2153, Blocks Bipolar Spindle Formation and Chromosome Alignment and Causes Prometaphase Accumulation during Mitosis of Human Lung Cancer Cells

2001 • 130 citations

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

2000 • 127 citations

Rho GTPase Control of Protein Kinase C-related Protein Kinase Activation by 3-Phosphoinositide-dependent Protein Kinase

2000 • 126 citations

Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells

2001 • 124 citations

The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts.

1991 • 115 citations

PRK1 Is Targeted to Endosomes by the Small GTPase, RhoB

1998 • 112 citations

The Farnesyl Transferase Inhibitor SCH 66336 Induces a G2 → M or G1 Pause in Sensitive Human Tumor Cell Lines

2001 • 112 citations

Activation of the PI3'K-AKT pathway masks the proapoptotic effects of farnesyltransferase inhibitors.

1999 • 105 citations

RhoB Is Stabilized by Transforming Growth Factor β and Antagonizes Transcriptional Activation

1998 • 101 citations

The p53 Tumor Suppressor Protein Does Not Regulate Expression of Its Own Inhibitor, MDM2, Except under Conditions of Stress

2000 • 86 citations

Regulation of Ras-related RhoB protein expression during the cell cycle.

1995 • 84 citations

Farnesyltransferase inhibitors: antineoplastic properties, mechanisms of action, and clinical prospects

2000 • 84 citations

rhoB Encoding a UV-inducible Ras-related Small GTP-binding Protein Is Regulated by GTPases of the Rho Family and Independent of JNK, ERK, and p38 MAP Kinase

1997 • 79 citations

GTPase RhoB: An Early Predictor of Neuronal Death after Transient Focal Ischemia in Mice

2001 • 66 citations

Ras-related GTPase RhoB Represses NF-κB Signaling

2001 • 61 citations

Ras-Related GTPase RhoB Forces Alkylation-Induced Apoptotic Cell Death

2000 • 49 citations

Geranylgeranylated RhoB is sufficient to mediate tissue‐specific suppression of Akt kinase activity by farnesyltransferase inhibitors

2000 • 47 citations

Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element

2001 • 46 citations

Rho GTPases Are Involved in the Regulation of NF-κB by Genotoxic Stress

2001 • 44 citations

K-Ras-Independent Effects of the Farnesyl Transferase Inhibitor L-744,832 on Cyclin B1/Cdc2 Kinase Activity, G2/M Cell Cycle Progression and Apoptosis in Human Pancreatic Ductal Adenocarcinoma Cell

2000 • 40 citations

Functional interaction between RhoB and the transcription factor DB1

1998 • 35 citations

Targeting farnesyltransferase: is Ras relevant?

1999 • 25 citations

Decreased sensitivity to 1-O-octadecyl-2-O-methyl-glycerophosphocholine in MCF-7 cells adapted for serum-free growth correlates with constitutive association of Raf-1 with cellular membranes.

1999 • 17 citations