Rapid development of severe hyperplastic gastritis with gastric epithelial dedifferentiation in Helicobacter felis-infected IL-10(-/-) mice.

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Helicobacter pyloriInfection and the Risk of Gastric Carcinoma

1991 • 3,869 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors

1996 • 1,883 citations

Helicobacter pyloriInfection and Gastric Carcinoma among Japanese Americans in Hawaii

1991 • 1,769 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

1996 • 1,128 citations

A standardized mouse model of Helicobacter pylori infection: Introducing the Sydney strain

1997 • 919 citations

Purification and characterization of the vacuolating toxin from Helicobacter pylori.

1992 • 700 citations

The Epidemiology of Helicobacter pylori Infection

1991 • 627 citations

Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

1994 • 594 citations

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

1995 • 537 citations

Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains.

1995 • 534 citations

Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants.

1996 • 494 citations

T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease.

1997 • 485 citations

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

1996 • 399 citations

Parasitism by the "slow" bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia.

1994 • 377 citations

Helicobacter-specific cell-mediated immune responses display a predominant Th1 phenotype and promote a delayed-type hypersensitivity response in the stomachs of mice.

1996 • 322 citations

Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis

1996 • 311 citations

Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis.

1995 • 258 citations

Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production.

1993 • 251 citations

Low biological activity of Helicobacter pylori lipopolysaccharide

1992 • 244 citations

Phylogeny of Helicobacter felis sp. nov., Helicobacter mustelae, and Related Bacteria

1991 • 233 citations

Atrophic gastric changes in both Helicobacter felis and Helicobacter pylori infected mice are host dependent and separate from antral gastritis.

1996 • 222 citations

Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts.

1994 • 203 citations

Compositional analysis of Helicobacter pylori rough-form lipopolysaccharides

1992 • 184 citations

Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice

1996 • 180 citations

Identification of murine helicobacters by PCR and restriction enzyme analyses

1996 • 171 citations

The role of Helicobacter species in newly recognized gastrointestinal tract diseases of animals.

1997 • 159 citations

Campylobacter pylori-associated gastritis and immune response in a population at increased risk of gastric carcinoma.

1989 • 120 citations

Interleukin-10 gene knock-out mice: a model of chronic inflammation

1995 • 118 citations

Local and systemic immune responses in murine Helicobacter felis active chronic gastritis

1993 • 113 citations

Pathophysiology of Helicobacter pylori infection.

1994 • 107 citations

Expression of Cytokine mRNA in Gastric Mucosa withHelicobacter pyloriInfection

1995 • 104 citations

Neutrophil Activation by Helicobacter pylori Lipopolysaccharides

1994 • 104 citations

Successful immunization against gastric infection with Helicobacter species: use of a cholera toxin B-subunit-whole-cell vaccine

1994 • 99 citations

Helicobacter pylori-specific CD4+ T-cell clones from peripheral blood and gastric biopsies

1995 • 95 citations

Immunological activity of lipopolysaccharide ofHelicobacter pylorion human peripheral mononuclear blood cells in comparison to lipopolysaccharides of other intestinal bacteria

1993 • 93 citations

The role of lipopolysaccharide in Helicobacter pylori pathogenesis.

1996 • 92 citations

The importance of local acid production in the distribution of Helicobacter felis in the mouse stomach

1995 • 84 citations

Detection of proliferating cell nuclear antigen in diagnostic histopathology.

1992 • 81 citations

A radical view of the stomach: the role of oxygen-derived free radicals and anti-oxidants in gastroduodenal disease.

1995 • 79 citations

The endotoxin of Helicobacter pylori is a modulator of host-dependent gastritis

1997 • 76 citations

Use of a Mouse Model to Examine Anti-Helicobacter pylori Agents

1991 • 62 citations

Humoral and cellular immune recognition of Helicobacter pylori proteins are not concordant

1994 • 61 citations

Inability of human clinical strains of Helicobacter pylori to colonize the alimentary tract of germfree rodents

1990 • 57 citations

Suppression of human mononuclear cell response byHelicobacter pylori: Effects on isolated monocytes and lymphocytes

1994 • 40 citations

Stimulatory effects of Helicobacter pylori on human peripheral blood mononuclear cells of H. pylori infected patients and healthy blood donors

1993 • 33 citations

Th1- and Th2-Type Cytokines Regulate Chemokine Expression

1996 • 33 citations

Roles of hepatocyte growth factor and its receptor in gastric mucosa

1995 • 33 citations

Effect of Helicobacter pylori Lipopolysaccharide (LPS) and LPS Derivatives on the Production of Tissue Factor and Plasminogen Activator Inhibitor Type 2 by Human Blood Mononuclear Cells

1996 • 32 citations

Helicobacter Infections in Laboratory Animals: A Model for Gastric Neoplasias?

1995 • 26 citations

Increased Expression of c-met Messenger RNA Following Acute Gastric Injury in Rats

1994 • 23 citations

Intravenous Helicobacter pylori induces low levels of TNF‐α and IL‐1α in a murine model

1994 • 11 citations

The use of a mouse model in the study of Helicobacter sp.-associated gastric cancer.

1994 • 5 citations