Isolation and characterization of the apolipoprotein E receptor from canine and human liver.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay

1973 • 3,279 citations

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose

1978 • 2,726 citations

The Metabolic Basis of Inherited Disease

1979 • 2,083 citations

The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations

1972 • 1,831 citations

The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

1984 • 1,386 citations

A new solid-state reagent to iodinate proteins

1982 • 893 citations

Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.

1978 • 621 citations

Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.

1979 • 571 citations

Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

1983 • 548 citations

Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process.

1980 • 428 citations

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

1981 • 424 citations

Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.

1981 • 391 citations

Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins.

1977 • 380 citations

Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.

1982 • 378 citations

Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.

1981 • 378 citations

Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

1984 • 377 citations

Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins.

1980 • 372 citations

Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.

1983 • 369 citations

Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia.

1981 • 359 citations

Effect of apoproteins on hepatic uptake of triglyceride emulsions in the rat.

1980 • 359 citations

A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis.

1980 • 358 citations

PHENOTYPIC STABILITY OF ADULT RAT HEPATOCYTES IN PRIMARY MONOLAYER CULTURE*

1980 • 347 citations

Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.

1981 • 316 citations

Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts.

1979 • 303 citations

Visualization of lipoprotein receptors by ligand blotting.

1983 • 273 citations

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

1983 • 261 citations

Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.

1982 • 260 citations

Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.

1981 • 254 citations

Metabolic Studies in Familial Hypercholesterolemia

1979 • 217 citations

Rate and equilibrium constants for binding of apo-E HDL _c (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: Evidence for multiple receptor binding of apo-E HDL _c

1979 • 215 citations

Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts.

1978 • 211 citations

Rates of low density lipoprotein uptake and cholesterol synthesis are regulated independently in the liver.

1985 • 206 citations

Characterization of the sinusoidal transport process responsible for uptake of chylomicrons by the liver.

1978 • 197 citations

Isoprotein specificity in the hepatic uptake of apolipoprotein E and the pathogenesis of familial dysbetalipoproteinemia.

1980 • 191 citations

Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex.

1980 • 173 citations

cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.

1983 • 168 citations

Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro.

1977 • 162 citations

Apoproteins of the lipoproteins in a nonrecirculating perfusate of rat liver

1976 • 161 citations

Structural and metabolic heterogeneity of beta-very low density lipoproteins from cholesterol-fed dogs and from humans with type III hyperlipoproteinemia.

1982 • 157 citations

Tissue sites of degradation of low density lipoprotein: Application of a method for determining the fate of plasma proteins

1979 • 132 citations

Binding of chylomicron remnants and beta-very low density lipoproteins to hepatic and extrahepatic lipoprotein receptors. A process independent of apolipoprotein B48.

1984 • 130 citations

Defective hepatic lipoprotein receptor binding of beta-very low density lipoproteins from type III hyperlipoproteinemic patients. Importance of apolipoprotein E.

1984 • 129 citations

Regulation of Hepatic Lipoprotein Receptors in the Dog. RAPID REGULATION OF APOLIPOPROTEIN B,E RECEPTORS, BUT NOT OF APOLIPOPROTEIN E RECEPTORS, BY INTESTINAL LIPOPROTEINS AND BILE ACIDS

1983 • 120 citations

Correlation of low and high density lipoprotein binding in vivo with rates of lipoprotein degradation in the rat. A comparison of lipoproteins of rat and human origin.

1982 • 118 citations

Tissue sites of degradation of native and reductively methylated [14C]sucrose-labeled low density lipoprotein in rats. Contribution of receptor-dependent and receptor-independent pathways.

1982 • 110 citations

An Electrophoretic Method for the Quantitative Isolation of Human and Swine Plasma Lipoproteins

1974 • 94 citations

High affinity binding of chylomicron remnants to rat liver plasma membranes.

1979 • 91 citations

The uptake of chylomicron remnants and very low density lipoprotein remnants by the perfused rat liver.

1984 • 70 citations

Functional unit of the low density lipoprotein receptor of fibroblasts: a 100,000-dalton structure with multiple binding sites.

1981 • 54 citations

[36] Purification of the LDL receptor

1985 • 48 citations

Uptake of apolipoprotein E-containing high density lipoproteins by hepatic parenchymal cells.

1984 • 45 citations

Receptor-mediated catabolism and tissue uptake of human low density lipoprotein in the cholesterol-fed, atherosclerotic rabbit

1982 • 31 citations

Partial Purification of the Apolipoprotein E Receptor of Rat Liver Membrane

1985 • 11 citations