Neurotrophin-3 Sorts to the Constitutive Secretory Pathway of Hippocampal Neurons and Is Diverted to the Regulated Secretory Pathway by Coexpression with Brain-Derived Neurotrophic Factor

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

2013 • 3,921 citations

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

1993 • 2,272 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

1995 • 1,354 citations

NEUROTROPHINS AND SYNAPTIC PLASTICITY

1999 • 1,343 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Rat hippocampal neurons in dispersed cell culture

1977 • 1,106 citations

Neurotrophin-evoked rapid excitation through TrkB receptors

1999 • 540 citations

Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons

1992 • 521 citations

Nerve Growth Factor Treatment Increases Brain-Derived Neurotrophic Factor Selectively in TrkA-Expressing Dorsal Root Ganglion Cells and in Their Central Terminations within the Spinal Cord

1997 • 500 citations

Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system

1997 • 500 citations

Proteolytic Processing in the Secretory Pathway

1999 • 455 citations

Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38)

1990 • 355 citations

Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

1996 • 349 citations

Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons

1999 • 335 citations

Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation

1983 • 329 citations

Regulated Release and Polarized Localization of Brain-Derived Neurotrophic Factor in Hippocampal Neurons

1996 • 325 citations

Neurotrophin trafficking by anterograde transport

1998 • 317 citations

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

1996 • 286 citations

Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: Inhibition by antibodies to NGF

1991 • 284 citations

The NeurotroDhins BDNF, NT-3 and NT-4/5 Promote Survival and Morphological and Biochemical Differentiation of Striatal NeuronsIn Vitro

1995 • 262 citations

Relative Contribution of Endogenous Neurotrophins in Hippocampal Long-Term Potentiation

1999 • 242 citations

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant.

1993 • 211 citations

Precursor Convertases: An Evolutionary Ancient, Cell‐Specific, Combinatorial Mechanism Yielding Diverse Bioactive Peptides and Proteins

1998 • 188 citations

The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM).

1994 • 135 citations

Brain‐Derived Neurotrophic Factor Levels in the Nervous System of Wild‐Type and Neurotrophin Gene Mutant Mice

1999 • 134 citations

Detection of Brain-derived Neurotrophic Factor in a Vesicular Fraction of Brain Synaptosomes

1997 • 128 citations

Structure of the Brain-Derived Neurotrophic Factor/Neurotrophin 3 Heterodimer

1995 • 120 citations

Nerve growth factor and the neurotrophic factor hypothesis

1996 • 113 citations

Sequence requirements for precursor cleavage within the constitutive secretory pathway.

1992 • 113 citations

Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus

1995 • 110 citations

Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector.

1988 • 110 citations

Peptide Processing and Targeting in the Neuronal Secretory Pathway

1991 • 107 citations

The Regulated Secretion and Vectorial Targeting of Neurotrophins in Neuroendocrine and Epithelial Cells

1996 • 92 citations

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases

1996 • 91 citations

α1-Antitrypsin Portland Inhibits Processing of Precursors Mediated by Proprotein Convertases Primarily within the Constitutive Secretory Pathway

1997 • 88 citations

A Protease Processing Site Is Essential for Prorenin Sorting to the Regulated Secretory Pathway

1996 • 84 citations

The Biosynthesis of Neurotrophin Heterodimers by Transfected Mammalian Cells

1995 • 67 citations

Subcellular localization of epitope-tagged neurotrophins in neuroendocrine cells

1998 • 62 citations

Interactions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3.BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors.

1994 • 61 citations

Neurotrophin-3 as an essential signal for the developing nervous system

1996 • 57 citations

Immunological relationships of NGF, BDNF, and NT-3: recognition and functional inhibition by antibodies to NGF

1993 • 54 citations

Evidence that Brain-Derived Neurotrophic Factor from Presynaptic Nerve Terminals Regulates the Phenotype of Calbindin-Containing Neurons in the Lateral Septum

2000 • 54 citations

Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non‐endocrine cell line, COS‐7

1992 • 51 citations

Purification and characterisation of a brain‐derived neurotrophic factor/ neurotrophin‐3 (BDNF/NT‐3) heterodimer

1994 • 51 citations

Formation of heterodimers from three neurotrophins, nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor.

1994 • 44 citations

Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion.

1991 • 37 citations

Heterodimers of the neurotrophic factors: Formation, isolation, and differential stability

1993 • 34 citations

Neuronal NT-3 Is not Required For Synaptic Transmission or Long-Term Potentiation in Area CA1 of the Adult Rat Hippocampus

1999 • 32 citations

Dimerization of lactase-phlorizin hydrolase occurs in the endoplasmic reticulum, involves the putative membrane spanning domain and is required for an efficient transport of the enzyme to the cell surface.

1996 • 31 citations

Processing and Secretion of Nerve Growth Factor: Expression in Mammalian Cells with a Vaccinia Virus Vector

1988 • 30 citations

Sequence requirements for proteolytic cleavage of precursors with paired basic amino acids

1991 • 23 citations

Differential sorting of lutropin and the free alpha-subunit in cultured bovine pituitary cells.

1992 • 22 citations

Human luteinizing hormone and chorionic gonadotropin are targeted to a regulated secretory pathway in GH3 cells.

1994 • 20 citations

Heterodimeric Neurotrophins Induce Phosphorylation of Trk Receptors and Promote Neuronal Differentiation in PC12 Cells

1995 • 17 citations

Perturbation of intestinal microvillar enzyme biosynthesis by amino acid analogs. Evidence that dimerization is required for the transport of aminopeptidase N out of the endoplasmic reticulum.

1990 • 16 citations

Human luteinizing hormone and chorionic gonadotropin are targeted to a regulated secretory pathway in GH3 cells

1994 • 8 citations