An Elevation in the Concentration of Free Cytosolic Calcium Is Sufficient to Activate the Oxidative Burst of Granulocytes Primed with Recombinant Human Granulocyte-Macrophage Colony-stimulating Factor

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Human bone marrow colony growth in agar‐gel

1970 • 1,317 citations

Recombinant Human Granulocyte Colony-Stimulating Factor: Effects on Normal and Leukemic Myeloid Cells

1986 • 1,260 citations

Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins

1985 • 1,253 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3

1986 • 823 citations

Molecular Cloning of a Complementary DNA Encoding Human Macrophage-Specific Colony-Stimulating Factor (CSF-1)

1985 • 542 citations

Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?

1983 • 471 citations

Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor.

1985 • 334 citations

Human GM-CSF primes neutrophils for enhanced oxidative metabolism in response to the major physiological chemoattractants

1987 • 333 citations

Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of bacteria by human neutrophils

1986 • 331 citations

Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system.

1985 • 315 citations

Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes.

1986 • 284 citations

NADPH oxidase of human neutrophils. Subcellular localization and characterization of an arachidonate-activatable superoxide-generating system.

1987 • 266 citations

Immune interferon enhances functional properties of human granulocytes: role of Fc receptors and effect of lymphotoxin, tumor necrosis factor, and granulocyte-macrophage colony-stimulating factor.

1987 • 254 citations

Biosynthetic human GM-CSF modulates the number and affinity of neutrophil f-Met-Leu-Phe receptors.

1986 • 218 citations

Correlation between membrane potential changes and superoxide production in human granulocytes stimulated by phorbol myristate acetate. Evidence for defective activation in chronic granulomatous disease.

1980 • 198 citations

Effects of recombinant human granulocyte and macrophage colony-stimulating factors on signal transduction pathways in human granulocytes.

1987 • 160 citations

Characterization of fMet-Leu-Phe receptor-mediated Ca2+ influx across the plasma membrane of human neutrophils.

1986 • 157 citations

Generation of superoxide radicals by human peripheral neutrophils activated by chemotactic factor. Evidence for the role of calcium.

1979 • 156 citations

Changes in Cytoplasmic pH and in Membrane Potential in Thrombin-Stimulated Human Platelets

1981 • 152 citations

Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187

1984 • 152 citations

Induction of proliferation of purified human myeloid progenitor cells: a rapid assay for granulocyte colony-stimulating factors

1984 • 93 citations

Probes of transmembrane potentials in platelets: changes in cyanine dye fluorescence in response to aggregation stimuli

1978 • 73 citations

Is intracellular Ca2+ the trigger for oxygen radical production by polymorphonuclear leucocytes?

1984 • 70 citations

Stimulus response coupling in the human neutrophil. Differential requirements for receptor occupancy in neutrophil responses to a chemoattractant.

1984 • 68 citations

Flavonoid impairment of neutrophil response

1986 • 66 citations

Effects of the myeloperoxidase system on fluorescent probes of granulocyte membrane potential.

1981 • 54 citations

The effects of phorbol myristate acetate and chemotactic peptide on transmembrane potentials and cytosolic free calcium in mature granulocytes evolve sequentially as the cells differentiate.

1987 • 35 citations

A transient rise in intracellular free calcium is not a sufficient stimulus for respiratory burst activation in human polymorphonuclear leukocytes

1985 • 23 citations

Effects of recombinant human granulocyte-macrophage colony-stimulating factor on intracellular pH in mature granulocytes

1988 • 23 citations

A new way for inducing a respiratory burst in guinea pig neutrophils

1981 • 21 citations

Intracellular acidification, guanine‐nucleotide binding proteins, and cytoskeletal actin

1987 • 18 citations

Cytochalasin B facilitates the inhibition of human polymorphonuclear leukocyte generation of superoxide by verapamil.

1984 • 12 citations

Spontaneous Induction of Superoxide Release and Degranulation of Neutrophils in Isotonic Potassium Medium: The Role of Intracellular Calcium

1986 • 5 citations