Is intracellular Ca2+ the trigger for oxygen radical production by polymorphonuclear leucocytes?

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Cytoplasmic free Ca²⁺ in human platelets: Ca²⁺ thresholds and Ca‐independent activation for shape‐change and secretion

1982 • 537 citations

Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?

1983 • 471 citations

STUDIES ON THE MECHANISM OF ACTION OF A NEW Ca²⁺ ANTAGONIST, 8‐(N,N‐DIETHYLAMINO)OCTYL 3,4,5‐TRIMETHOXYBENZOATE HYDROCHLORIDE IN SMOOTH AND SKELETAL MUSCLES

1975 • 347 citations

Mechanisms of Lysosomal Enzyme Release from Human Leukocytes: Microtubule Assembly and Membrane Fusion Induced by a Component of Complement

1973 • 329 citations

Transport of sodium, potassium, and calcium across rabbit polymorphonuclear leukocyte membranes. Effect of chemotactic factor.

1977 • 310 citations

Quantitative aspects of the production of superoxide radicals by phagocytizing human granulocytes.

1975 • 265 citations

The relationship between histamine secretion and ⁴⁵calcium‐uptake by mast cells

1977 • 265 citations

Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes.

1972 • 236 citations

Calcium Influx Requirement for Human Neutrophil Chemotaxis: Inhibition by Lanthanum Chloride

1976 • 222 citations

Phorbol 12-myristate 13-acetate activates rabbit neutrophils without an apparent rise in the level of intracellular free calcium

1983 • 217 citations

The roles of extracellular and intracellular calcium in lysosomal enzyme release and superoxide anion generation by human neutrophils

1981 • 205 citations

Direct demonstration of increased intracellular concentration of free calcium in rabbit and human neutrophils following stimulation by chemotactic factor

1983 • 199 citations

Phorbol myristate acetate-induced release of granule enzymes from human neutrophils: Inhibition by the calcium antagonist, 8-(N,N-diethylamino)-octyl 3,4,5-trimethoxybenzoate hydrochloride

1979 • 169 citations

Methods of Measuring Intracellular Calcium

1979 • 162 citations

Chemotactic Factor-Induced Release of Membrane Calcium in Rabbit Neutrophils

1979 • 161 citations

Diffusion-Enhanced Fluorescence Energy Transfer

1982 • 158 citations

Measurement of Intracellular Free Calcium in Monkey Kidney Cells with Aequorin

1982 • 151 citations

Calcium-induced lysozyme secretion from human polymorphonuclear leukocytes

1974 • 148 citations

Ion movement across leukocyte plasma membrane and excitation of their metabolism

1975 • 146 citations

The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils

1979 • 145 citations

Phagocytosis

1974 • 139 citations

Interaction of chemotactic factors with human polymorphonuclear leukocytes: Studies using a membrane potential-sensitive cyanine dye

1980 • 129 citations

Involvement of membrane calcium in the response of rabbit neutrophils to chemotactic factors as evidenced by the fluorescence of chlorotetracycline.

1979 • 128 citations

Ultrastructural Demonstration of Calcium Loss from Local Regions of the Plasma Membrane of Surface-Stimulated Human Granulocytes

1979 • 118 citations

The association of FAD with the cytochrome b–245 of human neutrophils

1982 • 112 citations

The NADPH-dependent O-.2-generating oxidase from human neutrophils.

1983 • 105 citations

Two distinct mechanisms for stimulation of oxygen-radical production by polymorphonuclear leucocytes

1983 • 98 citations

Stimulus–secretion coupling in rabbit neutrophils is not mediated by phosphatidylinositol breakdown

1980 • 97 citations

Stimulation of Ca2+-dependent chemiluminescence in rat polymorphonuclear leucocytes by polystyrene beads and the non-lytic action of complement.

1981 • 88 citations

Calmodulin inhibitors block neutrophil degranulation at a step distal from the mobilization of calcium

1980 • 84 citations

Measurement of changes in cytoplasmic free Ca2+ in fused cell hybrids

1982 • 83 citations

Clinical and biochemical luminescence

1982 • 82 citations

Use of cytochalasin B to distinguish between early and late events in neutrophil activation

1980 • 80 citations

Tetracycline fluorescence as calcium-probe for nerve membrane with some model studies using erythrocyte ghosts

1972 • 79 citations

Neutrophilic Leukocytes in Immunologic Reactions: Evidence for the Selective Release of Lysosomal Constituents

1972 • 79 citations

The effect of various stimuli and calcium antagonists on the fluorescence response of chlorotetracycline-loaded human neutrophils

1982 • 71 citations

Measurement of intracellular calcium ions and oxygen radicals in polymorphonuclear leucocyte‐erythrocyte ‘ghost’ hybrids.

1983 • 70 citations

Über den Leukocytenstoffwechsel bei der Phagocytose

1958 • 69 citations

Localization of submembranous cations to the leading end of human neutrophils during chemotaxis.

1979 • 60 citations

Effects of the myeloperoxidase system on fluorescent probes of granulocyte membrane potential.

1981 • 54 citations

Release of calcium from membranes and its relation to phagocytotic metabolic changes: A fluorescence study on leukocytes loaded with chlortetracycline

1980 • 50 citations

Aequorin measurements of free calcium in single mammalian cells

1983 • 48 citations

Polymorphonuclear leukocyte motility in vitro. VI. Effect of purine and pyrimidine analogues: possible role of cyclic AMP.

1972 • 45 citations

Trifluoperazine inhibition of calmodulin-sensitive Ca2+-ATPase and calmodulin insensitive (Na+ + K+)- and Mg2+-ATPase activities of human and rat red blood cells

1982 • 44 citations

Purified red blood cell Ca2+-pump ATPase: Evidence for direct inhibition by presumed anti-calmodulin drugs in the absence of calmodulin

1982 • 41 citations

Neutrophilic leukocytes in immunologic reactions in vitro. III. Pharmacologic modulation of lysosomal constituent release

1974 • 38 citations

Decrease in apparent K_m for oxygen after stimulation of respiration of rat polymorphonuclear leukocytes

1983 • 37 citations

Direct demonstration of increases in cytosolic free Ca2+ during stimulation of pancreatic enzyme secretion

1983 • 32 citations

The Limitations of Chlorotetracycline as a Fluorescent Probe of Divalent Cations Associated with Membranes

1980 • 32 citations

Oxygen radicals and tissue damage

1981 • 23 citations

Induction of chemiluminescence in human polymorphonuclear leukocytes by the calcium ionophore A23187

1978 • 23 citations

Complement-mediated lysis of pigeon erythrocyte ghosts analysed by flow cytometry. Evidence for the involvement of a ‘threshold’ phenomenon

1983 • 22 citations

Direct measurement of intracellular free Ca2+ in rat peritoneal macrophages: correlation with oxygen-radical production.

1983 • 17 citations

Lysosomal Enzyme Secretion and Volume Contraction Induced in Neutrophils by Cytochalasin B, Chemotactic Factor and A23187

1975 • 15 citations

The role of mitochondria in the regulation of calcium ion transport in synaptosomes

1980 • 14 citations

Bacillus Calmette-Guérin (BCG) decreases resistance to Listeria monocytogenes infection in mice.

1981 • 11 citations

Applications of coelenterate luminescent protein.

1982 • 3 citations