Mechanisms and modulation of resistance to chemotherapy in ovarian cancer

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

METALLOTHIONEIN

1986 • 1,606 citations

Taxol: A Unique Antineoplastic Agent with Significant Activity in Advanced Ovarian Epithelial Neoplasms

1989 • 1,111 citations

Taxol: A Novel Investigational Antimicrotubule Agent

1990 • 1,084 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Principles and Practice of Gynecologic Oncology

1992 • 933 citations

Second-line platinum therapy in patients with ovarian cancer previously treated with cisplatin.

1991 • 824 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

1985 • 545 citations

Charles F. Kettring prize. Fundamental studies with cisplatin

1985 • 514 citations

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

1987 • 425 citations

Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.

1985 • 410 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance.

1990 • 393 citations

Dose intensity analysis of chemotherapy regimens in ovarian carcinoma.

1987 • 385 citations

Short-termcis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells

1990 • 357 citations

Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.

1985 • 330 citations

Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II)

1988 • 314 citations

Chemotherapy in advanced ovarian cancer: an overview of randomised clinical trials. Advanced Ovarian Cancer Trialists Group.

1991 • 291 citations

Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation.

1991 • 288 citations

Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian cancer cell lines.

1988 • 281 citations

Chemotherapy in advanced ovarian cancer: An overview of randomised clinical trials

1991 • 272 citations

The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines

1991 • 262 citations

Response of patients in phase II studies of chemotherapy in ovarian cancer: implications for patient treatment and the design of phase II trials

1989 • 255 citations

High-dose cisplatin in hypertonic saline in refractory ovarian cancer.

1985 • 225 citations

Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione

1987 • 209 citations

Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.

1988 • 208 citations

Cyclophosphamide plus cisplatin versus cyclophosphamide, doxorubicin, and cisplatin chemotherapy of ovarian carcinoma: a meta-analysis. The Ovarian Cancer Meta-Analysis Project.

1991 • 186 citations

Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes

1989 • 184 citations

Metallothionein gene expression and resistance to cisplatin in human ovarian cancer

1990 • 181 citations

Genes amplified and overexpressed in human multidrug-resistant cell lines.

1988 • 170 citations

Effect of Glutathione on DNA Repair in Cisplatin-Resistant Human Ovarian Cancer Cell Lines

1989 • 168 citations

Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells.

1989 • 158 citations

Enhanced DNA repair and resistance to cisplatin in human ovarian cancer

1988 • 156 citations

High-dose carboplatin in refractory ovarian cancer patients.

1987 • 151 citations

P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines.

1989 • 144 citations

Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid.

1991 • 143 citations

Cross-linking of glutathione to DNA by cancer chemotherapeutic platinum coordination complexes

1987 • 140 citations

Rapid Emergence of Acquired cis-Diamminedichloroplatinum(II) Resistance in an In Vivo Model of Human Ovarian Carcinoma

1990 • 134 citations

Cyclophosphamide Plus Cisplatin Versus Cyclophosphomide, Doxorubicin, and Cisplatin Chemotherapy of Ovarian-carcinoma - a Metaanalysis

1991 • 132 citations

Expression of a human multidrug resistance gene in ovarian carcinomas.

1989 • 115 citations

Synergistic lethal effect of cis-dichlorodiammineplatinum and 1-beta-D-arabinofuranosylcytosine.

1981 • 115 citations

Chemotherapy of Ovarian Cancer

1984 • 107 citations

Depletion of Glutathione in Normal and Malignant Human Cells In Vivo by Buthionine Sulfoximine: Clinical and Biochemical Results

1992 • 102 citations

Adriamycin accumulation and metabolism in adriamycin-sensitive and -resistant human ovarian cancer cell lines

1986 • 100 citations

Increased removal of DNA-bound platinum in a human ovarian cancer cell line resistant to cis-diamminedichloroplatinum(II).

1990 • 98 citations

An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines

1990 • 97 citations

Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin.

1981 • 93 citations

European experience with ifosfamide in non-small cell lung cancer.

1989 • 85 citations

cis-diamminedichloroplatinum(II)-resistant sublines derived from two human ovarian tumor cell lines.

1988 • 77 citations

Resistance to alkylating agents and cisplatin: Insights from ovarian carcinoma model systems

1990 • 76 citations

Carrier-dependent and carrier-independent transport of anti-cancer alkylating agents

1981 • 68 citations

Overexpression of metallothionein in CHO cells and its effect on cell killing by ionizing radiation and alkylating agents

1989 • 66 citations

Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione.

1989 • 64 citations

Overexpression of DNA replication and repair enzymes in cisplatin-resistant human colon carcinoma HCT8 cells and circumvention by azidothymidine.

1989 • 63 citations

Phase I and Clinical Pharmacological Evaluation of Aphidicolin Glycinate

1991 • 58 citations

Platinum analogue combination chemotherapy: cisplatin and carboplatin--a phase I trial with pharmacokinetic assessment of the effect of cisplatin administration on carboplatin excretion.

1987 • 57 citations

1-beta-D-arabinofuranosylcytosine and hydroxyurea production of cytotoxic synergy with cis-diamminedichloroplatinum(II) and modification of platinum-induced DNA interstrand cross-linking.

1989 • 56 citations

Comparative cytotoxicity of CI‐973, cisplatin, carboplatin and tetraplatin in human ovarian carcinoma cell lines

1991 • 48 citations

Cross-resistance of vinblastine- and taxol-resistant mutants of Chinese hamster ovary cells to other anticancer drugs.

1985 • 42 citations

High-Dose Carboplatin With Diethyldithiocarbamate Chemoprotection in Treatment of Women With Relapsed Ovarian Cancer

1988 • 40 citations

Mechanisms of resistance to cisplatin and alkylating agents

1989 • 40 citations

Ovarian cancer, Part II: Treatment

1992 • 38 citations

Expression of P-glycoprotein in epithelial ovarian cancer: Evaluation as a marker of multidrug resistance

1990 • 37 citations

Serial determinations of glutathione levels and glutathione-related enzyme activities in human tumor cels in vitro

1986 • 35 citations

Mechanisms to improve chemotherapy effectiveness

1990 • 34 citations

The Effect of DNA Polymerase Inhibitors on the Cytotoxicity of Cisplatin in Human Ovarian Carcinoma Cells

1990 • 30 citations

Inhibition of radiation-induced DNA-protein cross-link repair by glutathione depletion with L-buthionine sulfoximine.

1988 • 24 citations

Glutathione S-Transferases and Anticancer Drug Resistance

1988 • 23 citations

Metallothionein-like proteins and cell resistance tocis-dichlorodiammineplatinum(II) in L1210 cells

1990 • 22 citations

Keynote address: Multidrug resistance: A pleiotropic response to cytotoxic drugs

1991 • 18 citations

Use of slow Ca2+ channel blockers to enhance inhibition by taxol of growth of drug-sensitive and -resistant Chinese hamster ovary cells.

1986 • 15 citations

Lack of significant modulation of the formation and removal of platinum-DNA adducts by aphidicolin glycinate in two logarithmically-growing ovarian tumour cell lines in vitro

1991 • 12 citations