The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly

Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures

2013 • 5,819 citations

Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

1982 • 1,429 citations

Growth of human hepatoma cells lines with differentiated functions in chemically defined medium.

1982 • 1,367 citations

THE MOLECULAR BIOLOGY OF THE HEPATITIS B VIRUSES

1987 • 1,046 citations

DNA Polymerase Associated with Human Hepatitis B Antigen

1973 • 741 citations

Hepatitis B virus genes and their expression in E. coli

1979 • 584 citations

SINGLE-STRANDED DNA BINDING PROTEINS REQUIRED FOR DNA REPLICATION

1986 • 563 citations

New Specificities in Australia Antigen Positive Sera Distinct from the Le Bouvier Determinants

1972 • 497 citations

A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA.

1990 • 412 citations

Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein

1990 • 365 citations

Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity

1990 • 355 citations

Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen.

1986 • 345 citations

Replication strategy of human hepatitis B virus

1987 • 314 citations

Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as well as for reverse transcription

1990 • 309 citations

The P gene product of hepatitis B virus is required as a structural component for genomic RNA encapsidation

1990 • 285 citations

SPKK, a new nucleic acid-binding unit of protein found in histone.

1989 • 237 citations

Immunochemical structure of hepatitis B e antigen in the serum.

1983 • 217 citations

A recombinant hepatitis B core antigen polypeptide with the protamine-like domain deleted self-assembles into capsid particles but fails to bind nucleic acids

1989 • 204 citations

Protein motifs that recognize structural features of DNA

1991 • 200 citations

The amino-terminal domain of the hepadnaviral P-gene encodes the terminal protein (genome-linked protein) believed to prime reverse transcription.

1988 • 198 citations

Mutations affecting hepadnavirus plus-strand DNA synthesis dissociate primer cleavage from translocation and reveal the origin of linear viral DNA

1991 • 163 citations

A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes.

1988 • 153 citations

Translational inactivation of RNA function: Discrimination against a subset of genomic transcripts during HBV nucleocapsid assembly

1990 • 146 citations

Nuclear factor 1 interacts with five DNA elements in the promoter region of the human cytomegalovirus major immediate early gene.

1986 • 137 citations

Immunogenicity of peptide fusions to hepatitis B virus core antigen.

1989 • 113 citations

Histone-DNA interactions and their modulation by phosphorylation of -Ser-Pro-X-Lys/Arg- motifs.

1991 • 113 citations

The molecular biology of hepatitis B virus

1989 • 106 citations

Expression and replication of the hepatitis B virus genome under foreign promoter control

1987 • 102 citations

HBc and HBe antigenicity and DNA-binding activity of major core protein P22 in hepatitis B virus core particles isolated from the cytoplasm of human liver cells

1985 • 101 citations

The duck hepatitis B virus core protein contains a highly phosphorylated C terminus that is essential for replication but not for RNA packaging

1989 • 86 citations

A domain of the hepadnavirus capsid protein is specifically required for DNA maturation and virus assembly

1991 • 84 citations

Total chemical synthesis of a gene for hepatitis B virus core protein and its functional characterization

1988 • 62 citations

Phosphorylation in the carboxyl-terminal domain of the capsid protein of hepatitis B virus: evaluation with a monoclonal antibody

1991 • 60 citations

Identification of a signal necessary for initiation of reverse transcription of the hepadnavirus genome

1991 • 48 citations

Mechanism of translation of the hepadnaviral polymerase (P) gene.

1990 • 44 citations

Proteaselike sequence in hepatitis B virus core antigen is not required for e antigen generation and may not be part of an aspartic acid-type protease

1989 • 24 citations

DNA-binding activity of hepatitis B e antigen polypeptide lacking the protaminelike sequence of nucleocapsid protein of human hepatitis B virus

1988 • 22 citations

PCR-based site-directed mutagenesis using primers with mismatched 3′-ends

1990 • 21 citations