Immunogenicity of peptide fusions to hepatitis B virus core antigen.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures

2013 • 5,819 citations

Prediction of protein antigenic determinants from amino acid sequences.

1981 • 3,715 citations

Calcium-dependent bacteriophage DNA infection

1970 • 2,743 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

Viral Hepatitis and Liver Disease

1985 • 1,886 citations

Pedigrees of some mutant strains of Escherichia coli K-12

1972 • 1,742 citations

The tac promoter: a functional hybrid derived from the trp and lac promoters.

1983 • 1,001 citations

Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

1982 • 854 citations

Large surface proteins of hepatitis B virus containing the pre-s sequence

1984 • 812 citations

Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli

1983 • 810 citations

Hepatitis B virus genes and their expression in E. coli

1979 • 584 citations

Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein

1987 • 335 citations

Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site

1987 • 319 citations

A synthetic peptide vaccine involving the product of the pre-S(2) region of hepatitis B virus DNA: protective efficacy in chimpanzees.

1986 • 239 citations

Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322

1979 • 239 citations

Induction of anti-HIV neutralizing antibodies by synthetic peptides.

1986 • 237 citations

Hepatitis B virus contains pre-S gene-encoded domains

1985 • 223 citations

Solid phase synthesis of polynucleotides. VI. Farther studies on polystyrene copolymers for the solid support

1982 • 219 citations

Immunochemical structure of hepatitis B e antigen in the serum.

1983 • 217 citations

Viral Hepatitis and Liver Disease

1988 • 202 citations

Immune response to hepatitis B virus core antigen (HBcAg): localization of T cell recognition sites within HBcAg/HBeAg.

1987 • 193 citations

Antiserum to a Synthetic Peptide Recognizes the HTLV-III Envelope Glycoprotein

1986 • 175 citations

Location and Chemical Synthesis of a Pre-S Gene Coded Immunodominant Epitope of Hepatitis B Virus

1984 • 170 citations

The expression of hybrid HIV:Ty virus-like particles in yeast

1987 • 163 citations

Electron microscopy of hepatitis B core antigen synthesized in E. coli

1982 • 155 citations

Hepatitis B virus antigens made in microbial cells immunise against viral infection.

1984 • 144 citations

Hepatitis B virus core antigen: synthesis in Escherichia coli and application in diagnosis.

1982 • 133 citations

The conversion of hepatitis B core antigen synthesized in e coli into e antigen

1981 • 132 citations

Neutralization of diverse HIV-1 strains by monoclonal antibodies raised against a gp41 synthetic peptide

1988 • 128 citations

Immune response to synthetic peptide analogues of hepatitis B surface antigen specific for the a determinant.

1982 • 125 citations

Hepatitis B virus vaccine: identification of HBsAg/a and HBsAg/d but not HBsAg/y subtype antigenic determinants on a synthetic immunogenic peptide.

1982 • 111 citations

T Lymphocyte Sensitization to Hbcag and T Cell–Mediated Unresponsiveness to Hbsag in Hepatitis B Virus–Related Chronic Liver Disease

1985 • 94 citations

Comparison of the nucleotide sequences of the initial transcribed regions of the tryptophan operons of Escherichia coli and Salmonella typhimurium

1978 • 85 citations

Expression of the hepatitis B virus surface, core and E antigen genes by stable rat and mouse cell lines

1982 • 78 citations

Induction of anti-human immunodeficiency virus (HIV) neutralizing antibodies in rabbits immunized with recombinant HIV--hepatitis B surface antigen particles.

1988 • 68 citations

Protective immunisation against hepatitis B with an internal antigen of the virus

1987 • 61 citations

Production of immunologically active surface antigens of hepatitis B virus by Escherichia coli.

1981 • 54 citations

Determination of the affinity of antibodies to hepatitis B surface antigen in human sera

1984 • 52 citations

Demonstration of Hepatitis B e Antigen (HBeAg) in Association with Intact Dane Particles

1979 • 39 citations

Alteration of Hepatitis B Antigen (HB Ag) Determinants by Reduction and Alkylation

1973 • 36 citations

Application of recombinant DNA techniques in the development of viral vaccines

1988 • 26 citations