Direct Binding of Toll-Like Receptor 2 to Zymosan, and Zymosan-Induced NF-κB Activation and TNF-α Secretion Are Down-Regulated by Lung Collectin Surfactant Protein A

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay

1973 • 3,279 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

1999 • 2,188 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

1999 • 1,905 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

1999 • 1,381 citations

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

1999 • 1,252 citations

Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

Dectin-1 Is A Major β-Glucan Receptor On Macrophages

2002 • 964 citations

Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products

1999 • 939 citations

Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis

1999 • 813 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Comparison of in vitro cell cytotoxic assays for tumor necrosis factor

1984 • 752 citations

Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies

1982 • 683 citations

Cutting Edge: Inflammatory Signaling byBorrelia burgdorferiLipoproteins Is Mediated by Toll-Like Receptor 2

1999 • 666 citations

Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex

2001 • 652 citations

The CD14 Ligands Lipoarabinomannan and Lipopolysaccharide Differ in Their Requirement for Toll-Like Receptors

1999 • 445 citations

Sterically Hindered Analogs of Thyroxine

1958 • 268 citations

Yeast Mannans inhibit binding and phagocytosis of zymosan by mouse peritoneal macrophages

1983 • 250 citations

Pulmonary surfactant proteins

1994 • 239 citations

A beta-glucan inhibitable receptor on human monocytes: its identity with the phagocytic receptor for particulate activators of the alternative complement pathway.

1985 • 216 citations

Surfactant Proteins A and D Bind CD14 by Different Mechanisms

2000 • 205 citations

Alveolar type II cells express a high-affinity receptor for pulmonary surfactant protein A.

1988 • 190 citations

The Extracellular Toll-like Receptor 2 Domain Directly Binds Peptidoglycan Derived from Staphylococcus aureus

2002 • 188 citations

Surface active materials from dog lung. I. Method of isolation

1972 • 185 citations

Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo

2000 • 184 citations

Pulmonary Surfactant Protein A Modulates the Cellular Response to Smooth and Rough Lipopolysaccharides by Interaction with CD14

1999 • 183 citations

Elevated Levels of Lung Surfactant Protein A in Sera from Patients with Idiopathic Pulmonary Fibrosis and Pulmonary Alveolar Proteinosis

1993 • 177 citations

Surfactant Protein A Inhibits Peptidoglycan-induced Tumor Necrosis Factor-α Secretion in U937 Cells and Alveolar Macrophages by Direct Interaction with Toll-like Receptor 2

2002 • 168 citations

Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen, and mannan binding protein inhibits TNF-alpha release.

1995 • 164 citations

Surfactant protein A protects growing cells and reduces TNF-alpha activity from LPS-stimulated macrophages

1996 • 159 citations

The C-type carbohydrate recognition domain (CRD) superfamily

1994 • 141 citations

Lung diseases caused by organic dusts in the farm environment

1986 • 135 citations

Molecular Mechanism of Tumor Necrosis Factor-α Production in 1→3-β-Glucan (Zymosan)-activated Macrophages

2001 • 135 citations

Pulmonary Mycotoxicosis

1975 • 111 citations

Both mannose and β-glucan receptors are involved in phagocytosis of unopsonized, heat-killed Saccharomyces cerevisiae by murine macrophages

1993 • 101 citations

Surfactant Protein A Down-Regulates Proinflammatory Cytokine Production Evoked byCandida albicansin Human Alveolar Macrophages and Monocytes

1999 • 82 citations

Zymosan-stimulated tumor necrosis factor-alpha production by human monocytes. Down-modulation by phorbol ester.

1992 • 69 citations

Extracellular Toll-Like Receptor 2 Region Containing Ser40-Ile64 but Not Cys30-Ser39 Is Critical for the Recognition ofStaphylococcus aureus Peptidoglycan

2001 • 62 citations

Transforming growth factor-beta primes macrophages to express inflammatory gene products in response to particulate stimuli by an autocrine/paracrine mechanism.

1993 • 60 citations

On the Composition of Zymosan

1958 • 47 citations

Zymosan induces selective release of arachidonic acid from rabbit alveolar macrophages via stimulation of a β-glucan receptor

1992 • 39 citations

Glucan receptor and zymosan-induced lysosomal enzyme secretion in macrophages

1995 • 29 citations

Differential systemic and intrapulmonary TNF-alpha production in Candida sepsis during immunosuppression

1992 • 29 citations

Signal Transduction Pathway on .BETA.-Glucans-Triggered Hydrogen Peroxide Production by Murine Peritoneal Macrophages in Vitro.

1996 • 20 citations

Zymosan-induced experimental hypersensitivity pneumonitis in rabbits.

1980 • 7 citations