Surfactant Protein A Inhibits Peptidoglycan-induced Tumor Necrosis Factor-α Secretion in U937 Cells and Alveolar Macrophages by Direct Interaction with Toll-like Receptor 2

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Peptidoglycan types of bacterial cell walls and their taxonomic implications

1972 • 3,772 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay

1973 • 3,279 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

1999 • 1,252 citations

BIOCHEMISTRY OF ENDOTOXINS

1990 • 1,201 citations

Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution

1986 • 1,093 citations

Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible toStaphylococcus aureusInfection

2000 • 1,046 citations

Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products

1999 • 939 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Comparison of in vitro cell cytotoxic assays for tumor necrosis factor

1984 • 752 citations

5 Analysis of the Chemical Composition and Primary Structure of Murein

1985 • 710 citations

CD14 Is a pattern recognition receptor

1994 • 706 citations

Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies

1982 • 683 citations

Immunomodulatory functions of surfactant

1997 • 589 citations

Proteins with leucine-rich repeats

1995 • 388 citations

Pulmonary Surfactant Protein A Enhances the Host-defense Mechanism of Rat Alveolar Macrophages

1990 • 375 citations

Distinct Effects of Surfactant Protein A or D Deficiency During Bacterial Infection on the Lung

2000 • 355 citations

Surfactant protein A-deficient mice are susceptible to group B streptococcal infection.

1997 • 346 citations

Effects of a surfactant-associated protein and calcium ions on the structure and surface activity of lung surfactant lipids

1985 • 326 citations

Surfactant Protein-A-Deficient Mice Are Susceptible toPseudomonas aeruginosaInfection

1998 • 318 citations

Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis by a direct interaction with human macrophages.

1995 • 309 citations

Alveolar lining layer is thin and continuous: low-temperature scanning electron microscopy of rat lung

1995 • 295 citations

Cutting Edge: Naturally Occurring Soluble Form of Mouse Toll-Like Receptor 4 Inhibits Lipopolysaccharide Signaling

2000 • 267 citations

Pulmonary surfactant proteins

1994 • 239 citations

Cloning and Characterization of Two Toll/Interleukin-1 Receptor–Like Genes TIL3 and TIL4: Evidence for a Multi-Gene Receptor Family in Humans

1998 • 222 citations

120-kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A.

1992 • 206 citations

Surfactant Proteins A and D Bind CD14 by Different Mechanisms

2000 • 205 citations

Tuning Antigen Receptor Signaling by CD22: Integrating Cues from Antigens and the Microenvironment

1997 • 195 citations

Surfactant Protein-A Binds Group B Streptococcus Enhancing Phagocytosis and Clearance from Lungs of Surfactant Protein-A–Deficient Mice

1999 • 195 citations

Alveolar type II cells express a high-affinity receptor for pulmonary surfactant protein A.

1988 • 190 citations

Surface active materials from dog lung. I. Method of isolation

1972 • 185 citations

Pulmonary Surfactant Protein A Modulates the Cellular Response to Smooth and Rough Lipopolysaccharides by Interaction with CD14

1999 • 183 citations

Elevated Levels of Lung Surfactant Protein A in Sera from Patients with Idiopathic Pulmonary Fibrosis and Pulmonary Alveolar Proteinosis

1993 • 177 citations

Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen, and mannan binding protein inhibits TNF-alpha release.

1995 • 164 citations

Binding of surfactant protein A to the lipid A moiety of bacterial lipopolysaccharides

1994 • 163 citations

[20] Isolation of peptidoglycan and soluble peptidoglycan fragments

1994 • 156 citations

The C-type carbohydrate recognition domain (CRD) superfamily

1994 • 141 citations

Decreased Surfactant Protein A in Patients with Bacterial Pneumonia

1993 • 138 citations

Surfactant proteins A and D increase in response to intratracheal lipopolysaccharide.

1996 • 132 citations

Binding of surfactant protein A (SP-A) to herpes simplex virus type 1-infected cells is mediated by the carbohydrate moiety of SP-A.

1992 • 132 citations

Increased Recovery of Surfactant Protein A in AIDS-related Pneumonia

1991 • 118 citations

Aggregation and opsonization of type A but not type B Hemophilus influenzae by surfactant protein A.

1994 • 116 citations

Induction of intra- and extra-cellular phospholipids in the lungs of rats exposed to silica

1986 • 97 citations

Peptidoglycan induces transcription and secretion of TNF-alpha and activation of lyn, extracellular signal-regulated kinase, and rsk signal transduction proteins in mouse macrophages.

1995 • 94 citations

Binding of Rat and Human Surfactant Proteins A and D toAspergillus fumigatusConidia

1999 • 85 citations

Surfactant Protein A Down-Regulates Proinflammatory Cytokine Production Evoked byCandida albicansin Human Alveolar Macrophages and Monocytes

1999 • 82 citations

Surfactant protein A in bronchoalveolar lavage fluid.

1992 • 79 citations

Analysis of Chimeric Proteins Identifies the Regions in the Carbohydrate Recognition Domains of Rat Lung Collectins That Are Essential for Interactions with Phospholipids, Glycolipids, and Alveolar Type II Cells

1998 • 55 citations

Rat Mannose-Binding Protein A Binds CD14

2001 • 33 citations

Human surfactant protein A with two distinct oligomeric structures which exhibit different capacities to interact with alveolar type II cells

1996 • 20 citations

Introduction of Mannose Binding Protein-Type Phosphatidylinositol Recognition into Pulmonary Surfactant Protein A

1999 • 18 citations