One adenosine deaminase allele in a patient with severe combined immunodeficiency contains a point mutation abolishing enzyme activity.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

Prediction of protein antigenic determinants from amino acid sequences.

1981 • 3,715 citations

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

1975 • 3,483 citations

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA

1982 • 764 citations

Human β-globin pre-mRNA synthesized in vitro is accurately spliced in xenopus oocyte nuclei

1983 • 500 citations

Enzyme electrophoresis on cellulose acetate gel: Zymogram patterns in man-mouse and man-Chinese hamster somatic cell hybrids

1971 • 349 citations

Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.

1985 • 329 citations

The construction of cosmid libraries which can be used to transform eukaryotic cells

1982 • 319 citations

Biochemistry of Diseases of Immunodevelopment

1981 • 242 citations

Three different mutations in codon 61 of the human N-rasgene detected by synthetic oligonucleotide hybridization

1984 • 167 citations

Cloning of cDNA sequences of human adenosine deaminase.

1983 • 83 citations

Molecular cloning of human adenosine deaminase gene sequences.

1983 • 71 citations

Adenosine Deaminase Deficiency and Severe Combined Immunodeficiency Disease

1980 • 69 citations

Structure of adenosine deaminase mRNAs from normal and adenosine deaminase-deficient human cell lines.

1984 • 60 citations

Isolation of cDNA clones for human adenosine deaminase

1983 • 58 citations

Cloning of human adenosine deaminase cDNA and expression in mouse cells

1984 • 51 citations

Immunoreactive protein in adenosine deaminase deficient human lymphoblast cell lines.

1982 • 44 citations

Adenosine deaminase (ADA) deficiency in cells derived from humans with severe combined immunodetficiency is due to an aberration of the ADA protein

1984 • 43 citations

Structure of Adenosine Deaminase mRNAs From Normal and Adenosine Deaminase-Deficient Human Cell Lines

1984 • 25 citations