Micronuclei formation with chromosome breaks and gene amplification caused by Vpr, an accessory gene of human immunodeficiency virus.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

A rapid in vivo test for chromosomal damage☆

1973 • 780 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B

1995 • 382 citations

Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.

1989 • 251 citations

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

1998 • 241 citations

HIV-1, Vpr and the cell cycle

1996 • 173 citations

Regulation and Mechanisms of Mammalian Gene Amplification

1993 • 163 citations

Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification.

1992 • 163 citations

Kinetochore localization in micronucleated cytokinesis-blocked Chinese hamster ovary cells: A new and rapid assay for identifying aneuploidy-inducing agents

1989 • 144 citations

Human Immunodeficiency VirusvprGene Encodes a Virion-Associated Protein

1990 • 126 citations

Micronuclei formation and aneuploidy induced byVpr, an accessory gene of human immunodeficiency virus type 1

1999 • 46 citations

p53-dependent growth arrest of REF52 cells containing newly amplified DNA.

1995 • 37 citations

Multiple mechanisms of N -phosphonacetyl- <scp>l</scp> -aspartate resistance in human cell lines: Carbamyl- P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged

1997 • 23 citations