Mouse Strain Susceptibility to Trypanosome Infection: An Arginase-Dependent Effect

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

2000 • 2,865 citations

Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity.

1997 • 1,109 citations

METABOLISM AND FUNCTIONS OF TRYPANOTHIONE IN THE KINETOPLASTIDA

1992 • 736 citations

Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of<scp>l</scp>-Arginine Metabolism

2001 • 674 citations

Alternative Metabolic States in Murine Macrophages Reflected by the Nitric Oxide Synthase/Arginase Balance: Competitive Regulation by CD4+ T Cells Correlates with Th1/Th2 Phenotype

1998 • 640 citations

Mechanisms of nitric oxide-related antimicrobial activity

1997 • 439 citations

Helicobacter pyloriarginase inhibits nitric oxide production by eukaryotic cells: A strategy for bacterial survival

2001 • 367 citations

Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major.

1994 • 302 citations

The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.

1995 • 270 citations

The Inhibition of Arginase by Nω-Hydroxy-<scp>l</scp>-Arginine Controls the Growth of Leishmania Inside Macrophages

2001 • 262 citations

Treatment of human African trypanosomiasis—present situation and needs for research and development

2002 • 259 citations

Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells

1998 • 254 citations

Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins.

1993 • 249 citations

Perspectives Series: Host/Pathogen Interactions

1997 • 228 citations

IL-10 Is Required for Prevention of Necrosis in the Small Intestine and Mortality in Both Genetically Resistant BALB/c and Susceptible C57BL/6 Mice Following Peroral Infection with Toxoplasma gondii

2000 • 220 citations

Co-induction of Arginase and Nitric Oxide Synthase in Murine Macrophages Activated by Lipopolysaccharide

1995 • 213 citations

Substrate Specificity of NO Synthases: Detailed Comparison of <scp>l</scp>-Arginine, Homo-<scp>l</scp>-arginine, Their N^ω-Hydroxy Derivatives, and N^ω-Hydroxynor-<scp>l</scp>-arginine

1998 • 190 citations

Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity.

1995 • 186 citations

Helicobacter pylori Induces Macrophage Apoptosis by Activation of Arginase II

2002 • 169 citations

<scp>l</scp>-Arginine Availability Modulates Local Nitric Oxide Production and Parasite Killing in Experimental Trypanosomiasis

2000 • 164 citations

Resistance to the African trypanosomes is IFN-gamma dependent.

1998 • 161 citations

Arginase I induction in macrophages, triggered by Th2‐type cytokines, supports the growth of intracellular Leishmania parasites

2002 • 155 citations

Arginases in parasitic diseases

2002 • 154 citations

Resistance to the African Trypanosomes Is IFN-γ Dependent

1998 • 141 citations

Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice

1999 • 140 citations

Cutting Edge: Urease Release by Helicobacter pylori Stimulates Macrophage Inducible Nitric Oxide Synthase

2002 • 131 citations

Induction of Mn SOD in human monocytes without inflammatory cytokine production by a mutant endotoxin

1998 • 128 citations

Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production.

1999 • 122 citations

Regulation of the genes for arginase isoforms and related enzymes in mouse macrophages by lipopolysaccharide

1999 • 106 citations

Anti-TGF-β Treatment Promotes Rapid Healing ofLeishmania majorInfection in Mice by Enhancing In Vivo Nitric Oxide Production

1999 • 96 citations

Inhibition of Inducible Nitric Oxide Synthase Exacerbates Chronic Cerebral Toxoplasmosis inToxoplasma gondii-Susceptible C57BL/6 Mice But Does Not Reactivate the Latent Disease inT. gondii-Resistant BALB/c Mice

1999 • 95 citations

Regulation of arginase isoforms I and II by IL-4 in cultured murine peritoneal macrophages

1999 • 93 citations

Cytokines and antibody responses during Trypanosoma congolense infections in two inbred mouse strains that differ in resistance

1999 • 77 citations

Stage-Dependent Role of Nitric Oxide in Control ofTrypanosoma cruziInfection

2001 • 74 citations

IFN-γ-Dependent Nitric Oxide Production Is Not Linked to Resistance in Experimental African Trypanosomiasis

1999 • 71 citations

Murine Macrophages Use Oxygen- and Nitric Oxide-Dependent Mechanisms To Synthesize S -Nitroso-Albumin and To Kill Extracellular Trypanosomes

1998 • 68 citations

The quantity of nitric oxide released by macrophages regulatesChlamydia-induced disease

2002 • 65 citations

Innate Resistance to Trypanosoma congolense Infections: Differential Production of Nitric Oxide by Macrophages from Susceptible BALB/c and Resistant C57Bl/6 Mice

1999 • 63 citations

Infection Stage-Dependent Modulation of Macrophage Activation inTrypanosoma congolense-Resistant and -Susceptible Mice

2002 • 61 citations

T-Cell Responses duringTrypanosoma bruceiInfections in Mice Deficient in Inducible Nitric Oxide Synthase

1999 • 55 citations

Parasitic load and histopathology of cutaneous lesions, lymph node, spleen, and liver from BALB/c and C57BL/6 mice infected with Leishmania mexicana.

2002 • 42 citations

Arginase production by peritoneal macrophages: A new assay

1980 • 26 citations

Murine Macrophages Use Oxygen- and Nitric Oxide-Dependent Mechanisms To Synthesize S-Nitroso-Albumin and To Kill Extracellular Trypanosomes

1998 • 9 citations