The hare and the tortoise: an embryonic haematopoietic race

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Purification and Characterization of Mouse Hematopoietic Stem Cells

1988 • 2,856 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region

1996 • 1,548 citations

An early haematopoietic defect in mice lacking the transcription factor GATA-2

1994 • 1,412 citations

Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors

2000 • 1,372 citations

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

1991 • 1,321 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

1991 • 1,074 citations

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1995 • 1,027 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1995 • 961 citations

A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis

1997 • 938 citations

Development of hematopoietic stem cell activity in the mouse embryo

1994 • 914 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

Progressive lineage analysis by cell sorting and culture identifies FLK1+VEcadherin+ cells at a diverging point of endothelial and hemopoietic lineages

1998 • 830 citations

Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development

1995 • 792 citations

HoxB4 Confers Definitive Lymphoid-Myeloid Engraftment Potential on Embryonic Stem Cell and Yolk Sac Hematopoietic Progenitors

2002 • 767 citations

The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages

1996 • 746 citations

HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo

2002 • 707 citations

Cbfa2 is required for the formation of intra-aortic hematopoietic clusters

1999 • 655 citations

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 • 630 citations

Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo

2000 • 620 citations

The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development

1994 • 616 citations

Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy

2002 • 612 citations

The transcriptional control of hematopoiesis [see comments]

1996 • 608 citations

A common precursor for primitive erythropoiesis and definitive haematopoiesis

1997 • 601 citations

Lymphoid Potential, Probed before Circulation in Mouse, Is Restricted to Caudal Intraembryonic Splanchnopleura

1996 • 591 citations

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

1995 • 582 citations

Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny

1998 • 577 citations

Runx1 Expression Marks Long-Term Repopulating Hematopoietic Stem Cells in the Midgestation Mouse Embryo

2002 • 573 citations

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

1995 • 546 citations

The cloche and spadetail Genes Differentially Affect Hematopoiesis and Vasculogenesis

1998 • 508 citations

Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development

2000 • 502 citations

Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development

1997 • 478 citations

Hematopoietic Stem Cells Localize to the Endothelial Cell Layer in the Midgestation Mouse Aorta

2002 • 477 citations

Aorta-associated CD34+ hematopoietic cells in the early human embryo

1996 • 461 citations

Relationship between vasculogenesis, angiogenesis and haemopoiesis during avian ontogeny

1989 • 460 citations

Studies on the origin of blood vessels and of red corpuscles as seen in the living blastoderm of the chick during the second day of incubation

1920 • 457 citations

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

1996 • 439 citations

Vasculogenesis in the day 6.5 to 9.5 mouse embryo

2000 • 437 citations

The SCL gene specifies haemangioblast development from early mesoderm

1998 • 430 citations

On the origin of haemopoietic stem cells in the avian embryo: an experimental approach

1975 • 399 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

In Vitro Generation of Lymphohematopoietic Cells from Endothelial Cells Purified from Murine Embryos

1998 • 372 citations

Fetal and Adult Hematopoietic Stem Cells Require β1 Integrin Function for Colonizing Fetal Liver, Spleen, and Bone Marrow

2000 • 371 citations

Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus.

1995 • 367 citations

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

1997 • 362 citations

Development of hematopoietic cells lacking transcription factor GATA-1

1995 • 362 citations

Intraembryonic, but Not Yolk Sac Hematopoietic Precursors, Isolated before Circulation, Provide Long-Term Multilineage Reconstitution

2001 • 348 citations

Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins

1996 • 348 citations

Differential Requirements for α4 Integrins during Fetal and Adult Hematopoiesis

1996 • 347 citations

The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.

1996 • 343 citations

The development in vitro of the blood of the early chick embryo

1932 • 336 citations

Characterization of the First Definitive Hematopoietic Stem Cells in the AGM and Liver of the Mouse Embryo

1996 • 326 citations

Critical Role of the TIE2 Endothelial Cell Receptor in the Development of Definitive Hematopoiesis

1998 • 314 citations

The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis

1998 • 302 citations

Emergence of intraembryonic hematopoietic precursors in the pre-liver human embryo

1999 • 299 citations

Failure of Embryonic Hematopoiesis andLethal Hemorrhages in Mouse Embryos Heterozygousfor a Knocked-In Leukemia Gene CBFB–MYH11

1996 • 296 citations

Diffuse intraembryonic hemopoiesis in normal and chimeric avian development

1981 • 286 citations

PU.1 Functions in a Cell-Autonomous Manner to Control the Differentiation of Multipotential Lymphoid–Myeloid Progenitors

1997 • 276 citations

Haploinsufficiency of AML1 Affects the Temporal and Spatial Generation of Hematopoietic Stem Cells in the Mouse Embryo

2000 • 249 citations

A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1

2000 • 247 citations

Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos

1996 • 247 citations

Potential intraembryonic hemogenic sites at pre-liver stages in the mouse

1995 • 237 citations

Defects in Hemopoietic Stem Cell Activity in Ikaros Mutant Mice

1999 • 230 citations

Distinct Origins of Adult and Embryonic Blood in Xenopus

2000 • 230 citations

A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection

1998 • 226 citations

In vitro hematopoietic and endothelial potential of flk-1 ^−/− embryonic stem cells and embryos

1999 • 224 citations

The Human Embryo, but Not Its Yolk Sac, Generates Lympho-Myeloid Stem Cells

2001 • 215 citations

CD34 Expression Patterns During Early Mouse Development Are Related to Modes of Blood Vessel Formation and Reveal Additional Sites of Hematopoiesis

1997 • 213 citations

α4 Integrins Regulate the Proliferation/Differentiation Balance of Multilineage Hematopoietic Progenitors In Vivo

1999 • 201 citations

Circulation of Hematopoietic Progenitors in the Mouse Embryo

1996 • 193 citations

Dissecting NK cell development using a novel alymphoid mouse model: investigating the role of the c-abl proto-oncogene in murine NK cell differentiation.

1999 • 186 citations

Mouse major histocompatibility class I gene expression begins at midsomite stage and is inducible in earlier-stage embryos by interferon.

1985 • 185 citations

Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region–derived stromal cells

2001 • 183 citations

Mice Homozygous for a Truncated Form of CREB-Binding Protein Exhibit Defects in Hematopoiesis and Vasculo-angiogenesis

1999 • 178 citations

Stem Cell Emergence and Hemopoietic Activity Are Incompatible in Mouse Intraembryonic Sites

1999 • 173 citations

Disruption of the Rev3l-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality

2000 • 165 citations

Dissecting NK Cell Development Using a Novel Alymphoid Mouse Model: Investigating the Role of the c-abl Proto-Oncogene in Murine NK Cell Differentiation

1999 • 163 citations

Development, differentiation, and phenotypic heterogeneity of murine tissue macrophages

1996 • 162 citations

Differentiation of the mouse hepatic primordium. II. Extrinsic origin of the haemopoietic cell line

1981 • 159 citations

The Molecular Characterization of the Fetal Stem Cell Marker AA4

1999 • 159 citations

Tracing the Progeny of the Aortic Hemangioblast in the Avian Embryo

2000 • 152 citations

Engraftment of Embryonic Hematopoietic Cells in Conditioned Newborn Recipients

1997 • 151 citations

Complementary patterns of expression of c-ets 1, c-myb and c-myc in the blood-forming system of the chick embryo

1989 • 147 citations

Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo

1993 • 145 citations

Molecular Identity of Hematopoietic Precursor Cells Emerging in the Human Embryo

1998 • 144 citations

The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects

1999 • 144 citations

Initiation of Murine Embryonic Erythropoiesis: A Spatial Analysis

1997 • 144 citations

The wall of the chick embryo aorta harbours M-CFC, G-CFC, GM-CFC and BFU-E

1988 • 141 citations

Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region

2000 • 120 citations

Evidence for the presence of murine primitive megakarycytopoiesis in the early yolk sac

2001 • 114 citations

Identification of Podocalyxin-like Protein 1 as a Novel Cell Surface Marker for Hemangioblasts in the Murine Aorta-Gonad-Mesonephros Region

1999 • 113 citations

Long-term repopulating abilities of enriched fetal liver stem cells measured by competitive repopulation.

1995 • 111 citations

Seeding of the 10-day mouse embryo thymic rudiment by lymphocyte precursors in vitro.

1981 • 109 citations

Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region

2000 • 109 citations

Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites

2000 • 108 citations

Hemopoietic stem cells in murine embryonic yolk sac and peripheral blood.

1989 • 107 citations

Expression of 4-Integrin Defines the Earliest Precursor of Hematopoietic Cell Lineage Diverged From Endothelial Cells

1999 • 99 citations

HCA, an Immunoglobulin-Like Adhesion Molecule Present on the Earliest Human Hematopoietic Precursor Cells, Is Also Expressed by Stromal Cells in Blood-Forming Tissues

1999 • 99 citations

Embryonic expression of the human GATA-3 gene

1999 • 98 citations

Detailed characterization of the human aorta-gonad-mesonephros region reveals morphological polarity resembling a hematopoietic stromal layer

1999 • 93 citations

Expression of zebrafish GATA 3 (gta3) during gastrulation and neurulation suggests a role in the specification of cell fate

1995 • 91 citations

The murine W/c-kit and Steel loci and the control of hematopoiesis.

1991 • 90 citations

In Vitro Hematopoietic and Endothelial Cell Development From Cells Expressing TEK Receptor in Murine Aorta-Gonad-Mesonephros Region

1999 • 87 citations

Functionally defined CD164 epitopes are expressed on CD34(+) cells throughout ontogeny but display distinct distribution patterns in adult hematopoietic and nonhematopoietic tissues.

2000 • 86 citations

Antigenic profiles of endothelial and hemopoietic lineages in murine intraembryonic hemogenic sites

1998 • 76 citations

Glycoprotein IIb-IIIa Is Expressed on Avian Multilineage Hematopoietic Progenitor Cells

1999 • 76 citations

“Hemogenic endothelium” of the embryonic aorta: Does it exist?

1982 • 74 citations

Differential expression of KDR/VEGFR-2 and CD34 during mesoderm development of the early human embryo

1999 • 72 citations

Distinct patterns of expression of MHC class I and beta 2-microglobulin transcripts at early stages of mouse development.

1991 • 68 citations

Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis

2001 • 64 citations

Early expression of endomucin on endothelium of the mouse embryo and on putative hematopoietic clusters in the dorsal aorta

2001 • 58 citations

The cell clusters in the dorsal aorta of mammalian embryos

1916 • 56 citations

Differential stem cell contributions to thymocyte succession during development of Xenopus laevis.

1992 • 54 citations

Definitive But Not Primitive Hematopoiesis Is Impaired injumonji Mutant Mice

1999 • 46 citations

The hemangioblast-an elusive cell captured in culture

1998 • 41 citations

Hematopoietic Commitment during Embryogenesis

1999 • 41 citations

Glycoprotein IIb-IIIa Is Expressed on Avian Multilineage Hematopoietic Progenitor Cells

1999 • 41 citations

Tenascin-C lines the migratory pathways of avian primordial germ cells and hematopoietic progenitor cells

1996 • 36 citations

Induction and early development of the hematopoietic and immune systems in Xenopus

1998 • 32 citations

Hematopoietic tissues, as a playground of receptor tyrosine kinases of the PDGF-receptor family

1998 • 25 citations

All B cells are progeny of endothelial cells: a new perspective

2000 • 12 citations

Interspecific cell markers and cell lineage in birds

1985 • 3 citations