A Novel Function of IL-12p40 as a Chemotactic Molecule for Macrophages

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.

1996 • 779 citations

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

1990 • 679 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4

1992 • 540 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

1991 • 471 citations

Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist

1995 • 441 citations

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.

1995 • 407 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

The CXC Chemokines IP-10 and Mig Are Necessary for IL-12-Mediated Regression of the Mouse RENCA Tumor

1998 • 295 citations

The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer

1993 • 292 citations

Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon

1994 • 223 citations

Interleukin 12 at the site of disease in tuberculosis.

1994 • 218 citations

Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma.

1992 • 205 citations

IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages.

1997 • 196 citations

Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts

1997 • 173 citations

Molecular Characterization of Interleukin 2

1982 • 168 citations

IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity.

1996 • 135 citations

Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells.

1997 • 112 citations

Molecular characterization of interleukin 12

1992 • 104 citations

Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection.

1996 • 101 citations

Inhibition of in vivo tumor growth by the beta chemokine, TCA3.

1994 • 83 citations

Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12‐hydroxy‐5,8,10,14‐eicosatetraenoic acid

1988 • 77 citations

Reduced T Helper 1 Responses in IL-12 p40 Transgenic Mice

1998 • 76 citations

Rapid recruitment of macrophages in interleukin‐12‐mediated tumour regression

1998 • 29 citations

CTL generation in the presence of IL-4 is inhibited by free p40: evidence for early and late IL-12 function.

1997 • 16 citations

Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth and susceptibility to IL-2 therapy of a murine melanoma

1991 • 11 citations