Sphingosine differentially inhibits activation of the Na+/H+ exchanger by phorbol esters and growth factors.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Intracellular pH.

1981 • 2,440 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Mechanisms of regulation of the Na+/H+ exchanger

1986 • 685 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

1984 • 447 citations

Volume regulation by Amphiuma red blood cells. The membrane potential and its implications regarding the nature of the ion-flux pathways.

1980 • 359 citations

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.

1986 • 307 citations

Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.

1986 • 294 citations

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

1989 • 247 citations

Activation of Na+/H+ exchange in lymphocytes by osmotically induced volume changes and by cytoplasmic acidification.

1983 • 209 citations

Glycoprotein, elastin, and collagen secretion by rat smooth muscle cells.

1979 • 174 citations

Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.

1988 • 172 citations

Serum, platelet-derived growth factor, vasopressin and phorbol esters increase intracellular pH in Swiss 3T3 cells

1983 • 170 citations

Domain structure and phosphorylation of protein kinase C.

1987 • 168 citations

Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.

1987 • 156 citations

Homologous and heterologous mitogenic desensitization of Swiss 3T3 cells to phorbol esters and vasopressin: Role of receptor and postreceptor steps

1984 • 154 citations

Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.

1988 • 151 citations

Platelet-derived growth factor stimulates Na+/H+ exchange and induces cytoplasmic alkalinization in NR6 cells.

1983 • 145 citations

Growth inhibition by protein kinase C late in mitogenesis

1987 • 133 citations

Interrelationship between growth factor-induced pH changes and intracellular Ca2+.

1987 • 128 citations

Stimulation of Na+H+ antiport activity by epidermal growth factor and insulin occurs without activation of protein kinase C

1985 • 112 citations

Thrombin activation of the Na+/H+ exchanger in vascular smooth muscle cells. Evidence for a kinase C-independent pathway which is Ca2+-dependent and pertussis toxin-sensitive.

1987 • 104 citations

Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway

1988 • 97 citations

Prevention of the TPA-mediated down-regulation of protein kinase C

1988 • 60 citations

Both protein kinase C and calcium mediate activation of the Na⁺/H⁺ antiporter in Chinese hamster embryo fibroblasts

1987 • 57 citations

Osmotic activation of the Na+H+ antiport in protein kinase C-depleted lymphocytes

1986 • 56 citations

Intracellular Ca2+ requirement for activation of the Na+/H+ exchanger in vascular smooth muscle cells.

1988 • 50 citations

Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells.

1986 • 49 citations

Proton transport and cell function.

1984 • 36 citations

Cyclosporin a inhibits kinase C-independent activation of the Na+H+ exchanger by PDGF and vanadate

1987 • 27 citations

Purification of 6-pyruvoyl-tetrahydropterin synthase from human liver

1986 • 18 citations