Mitochondrial involvement in the ageing process. Facts and controversies

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

The Biologic Clock: The Mitochondria?

1972 • 1,912 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

The Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria

1974 • 517 citations

MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

1992 • 490 citations

Annals of the New York Academy of Sciences

1953 • 475 citations

Distribution and threshold expression of the tRNA(Lys) mutation in skeletal muscle of patients with myoclonic epilepsy and ragged-red fibers (MERRF).

1992 • 330 citations

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing

1992 • 329 citations

Decline with age of the respiratory chain activity in human skeletal muscle

1994 • 325 citations

Hypoxemia Is Associated With Mitochondrial DNA Damage and Gene Induction

1991 • 325 citations

Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy

1994 • 298 citations

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration

1990 • 276 citations

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

1995 • 276 citations

Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

1982 • 242 citations

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

1992 • 237 citations

Multiple mitochondrial DNA deletions in an elderly human individual

1992 • 214 citations

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

1990 • 188 citations

Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly

1993 • 171 citations

Histochemistry in Pathology

1990 • 145 citations

The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages

1993 • 142 citations

Effects of physical activity and age on mitochondrial function

1996 • 134 citations

Age-associated damage in mitochondrial DNA in human hearts

1993 • 114 citations

Age-related human mtDNA deletions: a heterogeneous set of deletions arising at a single pair of directly repeated sequences.

1994 • 76 citations

Mitochondrial function in muscle from elderly athletes

1997 • 38 citations

Tetracyano-2,2-bipyridineiron(iii), an improved electron acceptor for the spectrophotometric assay of β-oxidation and of succinate dehydrogenase in intact mitochondria

1982 • 30 citations

X‐linked vacuolated myopathy: Membrane attack complex deposition on muscle fiber membranes with calcium accumulation on sarcolemma

1997 • 26 citations

Physiopathological processes of aging : towards a multicausal interpretation

1992 • 13 citations

Deleted Work

1955 • 0 citations