NEW IMMUNOLOGIC INSIGHTS INTO MECHANISMS OF ALLOGRAFT REJECTION

Adhesion receptors of the immune system

1990 • 6,585 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.

1989 • 1,000 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Leukocyte adhesion to endothelium in inflammation

1990 • 882 citations

IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.

1992 • 838 citations

THE ROLE OF ENDOTHELIAL CELLS IN INFLAMMATION

1990 • 808 citations

Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1

1992 • 737 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

1989 • 676 citations

Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.

1988 • 626 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system.

1989 • 547 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families

1988 • 448 citations

Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones

1986 • 437 citations

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

1990 • 395 citations

In vivo effects of monoclonal antibody to ICAM-1 (CD54) in nonhuman primates with renal allografts.

1990 • 369 citations

Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.

1977 • 357 citations

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

1989 • 355 citations

Evidence of functional lymphocytes in some (leaky) scid mice.

1988 • 347 citations

Tumor necrosis factor and interferon-gamma induce distinct patterns of endothelial activation and associated leukocyte accumulation in skin of Papio anubis.

1989 • 334 citations

Roles of Adhesion Molecules in T‐Cell Recognition: Fundamental Similarities between Four Integrins on Resting Human T Cells (LFA‐1, VLA‐4, VLA‐5, VLA‐6) in Expression, Binding, and Costimulation

1990 • 322 citations

The eosinophil as a mediator of damage to respiratory epithelium: A model for bronchial hyperreactivity

1988 • 317 citations

Molecular Components of T-Cell Recognition

1992 • 304 citations

Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions.

1981 • 292 citations

Randomized Controlled Trial of a Monoclonal Antibody against the Interleukin-2 Receptor (33B3.1) as Compared with Rabbit Antithymocyte Globulin for Prophylaxis against Rejection of Renal Allografts

1990 • 274 citations

Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction.

1991 • 267 citations

T lymphocyte adhesion to endothelial cells: mechanisms demonstrated by anti-LFA-1 monoclonal antibodies.

1986 • 246 citations

INTERCELLULAR ADHESION MOLECULE 1 ON LIVER ALLOGRAFTS DURING REJECTION

1989 • 238 citations

Regulation of Alloreactivity in Vivo by a Soluble Form of the Interleukin-1 Receptor

1990 • 235 citations

Altering Genes in Animals by Gene Targeting

1992 • 224 citations

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination.

1989 • 216 citations

Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection.

1987 • 206 citations

Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.

1988 • 179 citations

Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice.

1989 • 177 citations

Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood.

1992 • 168 citations

Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies.

1990 • 164 citations

Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice.

1990 • 149 citations

Alloantigen Recognition Is Preceded by Nonspecific Adhesion of Cytotoxic T Cells and Target Cells

1986 • 145 citations

Skin graft rejection by beta 2-microglobulin-deficient mice.

1992 • 142 citations

CYTOKINE AND T CELL RECEPTOR GENE EXPRESSION AT THE SITE OF ALLOGRAFT REJECTION1

1992 • 140 citations

Therapy with monoclonal antibody to interleukin 2 receptor spares suppressor T cells and prevents or reverses acute allograft rejection in rats.

1986 • 126 citations

I. EVIDENCE THAT ELEVATED LEVELS OF TUMOR NECROSIS FACTOR-ALPHA PREDICT REJECTION FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION

1990 • 118 citations

hu‐PBL‐SCID Mice: A Model for Human Immune Function, AIDS, and Lymphomagenesis

1991 • 118 citations

INTRAGRAFT CYTOKINE PROFILE DURING HUMAN LIVER ALLOGRAFT REJECTION 1, 2

1992 • 116 citations

Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor.

1991 • 109 citations

THE STRONG CORRELATION OF CYTOTOXIC T LYMPHOCYTE-SPECIFIC SERINE PROTEASE GENE TRANSCRIPTS WITH RENAL ALLOGRAFT REJECTION1,2

1992 • 104 citations

Membrane glycoprotein p150,95 of human cytotoxic T cell clone is involved in conjugate formation with target cells.

1987 • 103 citations

DIFFERENTIAL IN SITU EXPRESSION OF CYTOKINES IN RENAL ALLOGRAFT REJECTION

1991 • 102 citations

INDUCTION OF DR/IA ANTIGENS IN HUMAN LIVER ALLOGRAFTS

1985 • 100 citations

INTERLEUKIN 2 RECEPTOR-TARGETED THERAPY—RATIONALE AND APPLICATIONS IN ORGAN TRANSPLANTATION

1988 • 98 citations

T cell receptor V beta gene usage in a human alloreactive response. Shared structural features among HLA-B27-specific T cell clones.

1990 • 94 citations

T cell receptor beta-chain selection in human allograft rejection.

1989 • 81 citations

EVALUATION OF CYTOKINES AND CYTOKINE-INDUCED SECONDARY MESSAGES IN SERA OF PATIENTS AFTER LIVER TRANSPLANTATION

1990 • 77 citations

Functional characterization of infiltrating T lymphocytes in human hepatic allografts

1986 • 73 citations

SEQUENTIAL DETERMINATIONS OF URINARY CYTOLOGY AND PLASMA AND URINARY LYMPHOKINES IN THE MANAGEMENT OF RENAL ALLOGRAFT RECIPIENTS

1989 • 71 citations

SEQUENTIAL ANALYSIS OF IL-2 GENE TRANSCRIPTION IN RENAL TRANSPLANTS

1992 • 69 citations

INCREASED EXPRESSION OF CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ON HEPATOCYTES IN REJECTING HUMAN LIVER ALLOGRAFTS

1987 • 66 citations

II. EVIDENCE THAT ANTIBODY THERAPY AGAINST TUMOR NECROSIS FACTOR-ALPHA AND LYMPHOTOXIN ENHANCES CARDIAC ALLOGRAFT SURVIVAL IN RATS

1990 • 62 citations

Identification of IL 2R+ T cells and macrophages within rejecting rat cardiac allografts, and comparison of the effects of treatment with anti-IL 2R monoclonal antibody or cyclosporin.

1987 • 61 citations

EVALUATION OF SEQUENTIAL PLASMA AND URINARY TUMOR NECROSIS FACTOR ALPHA LEVELS IN RENAL ALLOGRAFT RECIPIENTS

1991 • 59 citations

CTL adhesion and antigen recognition are discrete steps in the human CTL-target cell interaction.

1987 • 52 citations

Specific prolongation of MHC class II disparate skin allografts by in vivo administration of anti-IFN-gamma monoclonal antibody.

1990 • 51 citations

RELATIONSHIP OF INTERFERON-GAMMA AND NEOPTERIN LEVELS DURING STIMULATION WITH ALLOANTIGENS IN VIVO AND IN VITRO

1986 • 46 citations

Maturation of cytotoxic T cells within sponge matrix allografts.

1983 • 45 citations

PROLONGATION OF CARDIAC ALLOGRAFT SURVIVAL IN RATS BY ANTI-TNF AND CYCLOSPORINE COMBINATION THERAPY

1992 • 45 citations

T cell receptor gene segment utilization by HLA-DR1-alloreactive T cell clones.

1991 • 44 citations

Analysis of the donor-specific cytotoxic T lymphocyte repertoire in a patient with a long term surviving allograft. Frequency, specificity, and phenotype of donor-reactive T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ clones.

1990 • 43 citations

Expression of adhesion molecules on lymphocytes/monocytes and hepatocytes in human liver grafts

1990 • 37 citations

CHRONIC HUMAN SKIN GRAFT REJECTION IN SEVERE COMBINED IMMUNODEFICIENT MICE ENGRAFTED WITH HUMAN PBL FROM AN HLA-PRESENSITIZED DONOR

1992 • 35 citations

Clonal analysis of graft-infiltrating lymphocytes from renal and cardiac biopsies dominant rearrangements of TcRβ genes and persistence of dominant rearrangements in serial biopsies

1990 • 34 citations

Asymmetric selection of T cell antigen receptor alpha- and beta-chains in HLA-B27 alloreactivity.

1992 • 31 citations

Lymphocyte entry into inflammatory tissues in vivo. Qualitative differences of high endothelial venule-like vessels in sponge matrix allografts vs isografts.

1989 • 28 citations

Phenotypic and functional analysis of T cell receptor gamma delta-bearing cells isolated from human heart allografts.

1991 • 26 citations

T CELL RECEPTOR Vβ GENE USAGE IN ALLOGRAFT-DERIVED CELL LINES ANALYZED BY A POLYMERASE CHAIN REACTION TECHNIQUE1

1992 • 25 citations

INTERLEUKIN 2, INTERFERON, AND LYMPHOTOXIN IN RENAL TRANSPLANT RECIPIENTS1 Pressented at the 6th Annual Meeting of the American Society of Transplant Physicians, May 1987, Chicago, IL

1988 • 23 citations

The diabetic "human reconstituted" severe combined immunodeficient (SCID-hu) mouse: a model for isogeneic, allogeneic, and xenogeneic human islet transplantation.

1991 • 16 citations

Transplantation tolerance

1991 • 13 citations

T-cell receptor gene usage and expression in renal allograft-derived T-cell lines

1990 • 13 citations

Patterns of adhesion molecule expression in human liver allografts.

1991 • 8 citations

Relationship between leukocytic infiltration and endothelial specialization in murine cardiac allografts

1990 • 5 citations

Lymphocyte traffic and distribution after sponge matrix allograft using limiting dilution analysis.

1988 • 2 citations