A critical review of brain cholesterol metabolism

Regional Neurochemistry

1962 • 815 citations

Distribution of lipids in subcellular particles of guinea-pig brain

1964 • 476 citations

Exchange of Phospholipids between Liver Mitochondria and Microsomes in Vitro

1968 • 375 citations

Regulation of Cholesterol Metabolism

1970 • 341 citations

Developmental Neurobiology

1971 • 332 citations

Biochemistry of the developing nervous system

1956 • 304 citations

The lipid composition of rat brain myelin and subcellular fractions during development

1968 • 296 citations

THE BIOSYNTHESIS OF CHOLESTEROL FROM ACETATE-1-C14 BY CELLULAR FRACTIONS OF RAT LIVER

1956 • 271 citations

STUDIES ON THE SITE OF THE FEEDBACK CONTROL OF CHOLESTEROL SYNTHESIS*†

1960 • 271 citations

The Blood-Brain Barrier

1961 • 256 citations

Prenatal and postnatal growth and development of the central nervous system of the pig

1967 • 253 citations

THE EXTRAHEPATIC SYNTHESIS OF CHOLESTEROL

1950 • 231 citations

THE BIOLOGICAL CONVERSION OF CHOLESTEROL TO CHOLIC ACID

1943 • 229 citations

The in vitro Interchange of Cholesterol Between Plasma and Red Cells.

1951 • 226 citations

BODY CHOLESTEROL METABOLISM IN MAN. I. THE EQUILIBRATION OF SERUM AND TISSUE CHOLESTEROL*†

1962 • 200 citations

The study of metabolic turnover rates by means of isotopic tracers

1953 • 156 citations

THE UTILIZATION OF ACETIC ACID FOR THE SYNTHESIS OF FATTY ACIDS

1945 • 153 citations

The turnover of myelin in the adult rat

1968 • 149 citations

DEUTERIUM AS AN INDICATOR IN THE STUDY OF INTERMEDIARY METABOLISM

1937 • 147 citations

SYNTHESIS OF CHOLESTEROL IN SURVIVING LIVER

1946 • 139 citations

A Novel Mode of Inhibition of Cholesterol Biosynthesis

1963 • 130 citations

LIPID METABOLISM IN BRAIN DURING MYELINATION

1940 • 124 citations

The turnover of the lipid components of myelin

1965 • 115 citations

Phospholipid synthesis and exchange in isolated liver cells

1970 • 98 citations

Undernutrition and the Developing Brain: The use of Animal Models to Elucidate the Human Problem

1971 • 97 citations

Cholesterol ester metabolism in the brain: Properties and subcellular distribution of cholesterol-esterifying enzymes and cholesterol ester hydrolases in adult rat brain

1971 • 96 citations

THE OCCURRENCE OF ESTERIFIED CHOLESTEROL IN THE DEVELOPING NERVOUS SYSTEM

1959 • 95 citations

THE DEPOSITION AND DISPOSAL OF (4‐¹⁴C) CHOLESTEROL IN THE BRAIN OF GROWING CHICKENS

1958 • 94 citations

Studies on the Biosynthesis of Glycolipides and Other Lipides of the Brain

1959 • 92 citations

AN IN VITRO SYSTEM FOR THE STUDY OF MYELIN SYNTHESIS¹

1969 • 91 citations

Metabolism of brain glycolipid fatty acids

1966 • 90 citations

The identification and significance of desmosterol in the developing human and animal brain

1963 • 87 citations

Isotopic studies of the biosynthesis of the cerebroside fatty acids in rats

1963 • 82 citations

Metabolism of the Nervous System

1958 • 81 citations

CHEMICAL AND METABOLIC STUDIES OF RAT MYELIN OF THE CENTRAL NERVOUS SYSTEM^*

1965 • 75 citations

Brain Sterol Metabolism

1965 • 75 citations

Influence of the thyroid on the synthesis of cholesterol by liver and skin in vitro

1958 • 72 citations

Lipid composition of human intracranial tumors: A biochemical study

1963 • 69 citations

METABOLISM OF MYELIN:

1959 • 69 citations

Occurrence of desmosterol in developing rat brain

1962 • 68 citations

A STUDY OF BRAIN REPAIR IN THE RAT BY THE USE OF TRYPAN BLUE

1920 • 68 citations

OCCURRENCE AND SIGNIFICANCE OF STEROL PRECURSORS OF CHOLESTEROL IN HUMAN BRAIN TUMOURS*

1964 • 68 citations

THE EFFECT OF FASTING UPON LIPOGENESIS IN THE INTACT RAT

1952 • 65 citations

Biosynthesis of Cholesterol

1952 • 64 citations

THE INFLUENCE OF GROWTH AND MYELINATION ON THE DEPOSITION AND METABOLISM OF LIPIDS IN THE BRAIN

1941 • 62 citations

Effect of long-term administration of AY-9944, an inhibitor of 7-dehydrocholesterol Δ7-reductase, on serum and tissue lipids in the rat

1968 • 62 citations

Distribution of labeled cholesterol in animal tissues

1962 • 60 citations

Analysis of lipids from fresh and preserved adult human brains

1962 • 58 citations

CHEMICAL TOPOGRAPHY OF THE BRAIN

1938 • 58 citations

CONCENTRATION AND FATTY ACID COMPOSITION OF CHOLESTERYL ESTERS OF NORMAL HUMAN BRAIN¹

1969 • 56 citations

CHOLESTEROL ESTERS IN DEVELOPING RAT BRAIN: CONCENTRATION AND FATTY ACID COMPOSITION¹

1972 • 56 citations

THE ENTRY OF CHOLESTEROL INTO RAT BRAIN DURING DEVELOPMENT

1963 • 56 citations

The study of metabolic turnover rates by means of isotopic tracers

1953 • 54 citations

Turnover of brain mitochondrial membrane lipids

1966 • 52 citations

THE EFFECT OF HYPOCHOLESTEREMIC AGENTS ON MYELINOGENESIS

1969 • 51 citations

LIPID METABOLISM IN BRAIN AND OTHER TISSUES OF THE RAT

1940 • 48 citations

INCORPORATION OF INJECTED CHOLESTEROL INTO THE MYELINATING BRAIN OF THE 17‐DAY‐OLD RABBIT*

1963 • 48 citations

BRAIN CHOLESTEROL: BIOSYNTHESIS WITH SELECTED PRECURSORS IN VIVO

1961 • 47 citations

LIPID COMPOSITION OF HUMAN GLIAL TUMOUR AND ADJACENT BRAIN*

1967 • 47 citations

Rapid uptke of [1-14C] acetate by the adult rat brain 15 seconds after carotid injection

1971 • 43 citations

THE METABOLISM OF CHOLESTEROL AND FATTY ACIDS IN THE CENTRAL NERVOUS SYSTEM*

1959 • 42 citations

STUDIES OF METABOLIC TURNOVER WITH TRITIUM AS A TRACER

1954 • 40 citations

Exchange of sterols between myelin and other membranes of developing rat brain

1971 • 40 citations

THE FORMATION OF PHOSPHOLIPIDS FROM ¹⁴C–LABELLED PRECURSORS IN DEVELOPING RAT BRAIN IN VIVO*

1963 • 38 citations

Desmosterol in developing rat brain

1965 • 35 citations

CONCERNING INCORPORATION OF LABELLED CHOLESTEROL, FED TO THE MOTHERS, INTO BRAIN CHOLESTEROL OF 20‐DAY‐OLD SUCKLING RATS*

1961 • 35 citations

Incorporation of C14 of Acetate-1-C14 and Pyruvate-2-C14 into Brain Cholesterol in the Intact Rat

1957 • 34 citations

The biosynthesis of cholesterol and other sterols by brain tissue: I. Subcellular biosynthesis in vitro

1971 • 33 citations

The Binding of Sterols in Cellular Membranes

1967 • 31 citations

Carl Koller and the Development of Local Anesthesia

1967 • 31 citations

STEROLS WITH 29, 28 AND 27 CARBON ATOMS METABOLICALLY RELATED TO CHOLESTEROL, OCCURRING IN DEVELOPING AND MATURE BRAIN

1968 • 30 citations

Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain

1969 • 30 citations

Enzymic formation of esters of methyl sterol precursors of cholesterol

1971 • 30 citations

THE BIOSYNTHESIS OF CHOLESTEROL AND OTHER STEROLS BY BRAIN TISSUE.

1971 • 27 citations

Weights of various parts of the brain in normal and underfed albino rats at different ages

1918 • 26 citations

Incorporation of cholesterol into the central nervous system and its autoradiographic localization

1966 • 25 citations

Formation of Methyl Sterols in Brain Cholesterol Biosynthesis

1972 • 25 citations

CHOLESTEROL TURNOVER IN BRAIN SUBCELLULAR PARTICLES

1967 • 23 citations

The biosynthesis of cholesterol and other sterols by brain tissue: II. A comparison of in vitro and in vivo methods

1971 • 21 citations

Brain cholesterol. XI. A review of biosynthesis in adult mice

1965 • 21 citations

Lipid biosynthesis in neuron-enriched and glial-enriched fractions of rat brain: Sterol formation

1971 • 20 citations

CHOLESTEROL ESTERS IN THE WHITE MATTER OF ADULT HUMAN BRAIN, SERUM AND CEREBROSPINAL FLUID

1967 • 20 citations

Blood-Brain Barrier and Ground Substance of Central Nervous System

1955 • 20 citations

Intracerebral incorporation of [2-14C]mevalonic acid into adult rat brain squalene and cholesteroll

1959 • 19 citations

Brain Cholesterol: The Effect of Chemical and Physical Agents

1967 • 19 citations

Studies on the inhibitory mechanism of some hypocholesterolemic agents on 7-dehydrocholesterol Δ7-bond reductase activity

1965 • 19 citations

Uptake of cerebroside, cholesterol and lecithin by brain myelin and mitochondria

1968 • 19 citations

DEPOSITION OF TRITIUM LABELLED STEROLS (CHOLESTEROL, SITOSTEROL, LANOSTEROL) IN BRAIN and OTHER ORGANS OF THE GROWING CHICKEN*

1962 • 18 citations

Cholesterol and mevalonate metabolism: a time course study in vivo

1961 • 18 citations

AN ENZYME HISTOCHEMICAL AND BIOCHEMICAL STUDY OF THE EFFECT OF AN INHIBITOR OF CHOLESTEROL SYNTHESIS ON MYELINATING MOUSE BRAIN†

1964 • 17 citations

THE BIOSYNTHESIS OF CHOLESTEROL AND OTHER STEROLS BY BRAIN TISSUE

1972 • 16 citations

A METHOD FOR THE STUDY OF CHOLESTEROL BIOSYNTHESIS IN THE CENTRAL NERVOUS SYSTEM

1969 • 15 citations

Brain Cholesterol The Effect of its Development on Incorporation of Acetate-2-3H and Glucose-U-14

1964 • 14 citations

Conversion of squalene into sterols by microsomal fractions from brains of developing rats

1972 • 13 citations

The compartmentation of non-esterified and esterified cholesterol in the superovulated rat ovary

1971 • 12 citations

STRUCTURAL AND BIOCHEMICAL MATURATION OF THE CEREBRAL PALLIUM IN RABBIT FETUSES: MORPHOGENESIS AND LIPIDS

1971 • 12 citations

Persistence of Sterols other than Cholesterol in Chicken Tissues

1961 • 9 citations

Biosynthesis of Sterols in Developing Brain

1971 • 9 citations

The Incorporation of Cholesterol into the Nervous System of the Newly Hatched Chick

1970 • 9 citations

Malonyl CoA — A new intermediate in the formation of mevalonic acid

1962 • 8 citations

Hormonal effects on hepatic cholesterol biosynthesis and esterification

1971 • 6 citations

The Biochemistry of Myelinogenesis in the Central Nervous System

1971 • 5 citations

Brain cholesterol. XII. The incorporation of 1‐¹⁴C‐acetate into baboon sterol

1967 • 4 citations

Cholesterol Biosynthesis in Liver Tissue

1971 • 3 citations