Brain Cholesterol: The Effect of Chemical and Physical Agents

Thomas, Springfield, Illinois

1965 • 2,935 citations

THE QUANTITATIVE HISTOCHEMISTRY OF BRAIN

1954 • 1,033 citations

Biochemistry and the central nervous system

1986 • 794 citations

The Biological Synthesis of Cholesterol

1965 • 524 citations

Metabolism and Physiological Significance of Lipids

1963 • 482 citations

THE ADRENAL CORTEX AND HOMEOSTASIS

1950 • 419 citations

Metabolism of the Nervous System

1957 • 372 citations

Biochemistry of the Developing Nervous System

1956 • 334 citations

STUDIES ON THE SITE OF THE FEEDBACK CONTROL OF CHOLESTEROL SYNTHESIS*†

1960 • 271 citations

The Dynamic State of Body Constituents

1942 • 266 citations

The Blood-Brain Barrier

1961 • 256 citations

A treatise on the chemical constitution of the brain.

1963 • 236 citations

ANOXIA AND BRAIN POTENTIALS

1938 • 231 citations

THE EXTRAHEPATIC SYNTHESIS OF CHOLESTEROL

1950 • 231 citations

THE BIOLOGICAL CONVERSION OF CHOLESTEROL TO CHOLIC ACID

1943 • 229 citations

Biochemistry of the Developing Nervous System

1956 • 220 citations

Mevalonic Acid Pyrophosphate and Isopentenylpyrophosphate

1959 • 218 citations

Cholesterol Biosynthesis in Preparations of Liver from Normal, Fasting, X-irradiated, Cholesterol-fed, Triton, or Δ4-Cholesten-3-one-treated Rats

1959 • 203 citations

BODY CHOLESTEROL METABOLISM IN MAN. I. THE EQUILIBRATION OF SERUM AND TISSUE CHOLESTEROL*†

1962 • 200 citations

Metabolism and Physiological Significance of Lipids

1965 • 197 citations

Studies of Cholesterol Biosynthesis

1960 • 196 citations

γ,γ‐Dimethyl‐allyl‐pyrophosphat und Geranyl‐pyrophosphat, biologische Vorstufen des Squalens Zur Biosynthese der Terpene, VI¹⁾

1959 • 196 citations

THE UTILIZATION OF β-HYDROXY-β-METHYL-δ-VALEROLACTONE IN CHOLESTEROL BIOSYNTHESIS

1956 • 186 citations

Biosynthesis of Terpenes

1960 • 184 citations

Studies on the biosynthesis of cholesterol: XII. synthesis of allyl pyrophosphates from mevalonate and their conversion into squalene with liver enzymes*

1960 • 176 citations

The development of the purkinje cells and of the cortical layers in the cerebellum of the albino rat

1911 • 169 citations

THE UTILIZATION OF ACETIC ACID FOR THE SYNTHESIS OF FATTY ACIDS

1945 • 153 citations

Thin-layer chromatography of sterols and steroids

1963 • 148 citations

Studies on Local Anesthetics. Pharmacological Properties of Homologaes and Isomeres of Xylocnin (Alkyl Amino‐Acyl Derivatives)

1949 • 147 citations

DEUTERIUM AS AN INDICATOR IN THE STUDY OF INTERMEDIARY METABOLISM

1937 • 147 citations

NEUROPSYCHIATRIC ASPECTS OF CUSHING'S SYNDROME

1952 • 146 citations

SYNTHESIS OF CHOLESTEROL IN SURVIVING LIVER

1946 • 139 citations

ON THE CONVERSION OF SQUALENE TO LANOSTEROL IN VITRO

1957 • 136 citations

A BIOCHEMICAL AND MORPHOLOGIC STUDY OF MYELINATION AND DEMYELINATION

1958 • 134 citations

ON THE DEMETHYLATION OF LANOSTEROL TO CHOLESTEROL

1957 • 130 citations

Lipids of peripheral nerve

1948 • 125 citations

LIPID METABOLISM IN BRAIN DURING MYELINATION

1940 • 124 citations

The Biology of Mental Health and Disease

1952 • 121 citations

Congenitale Encephalitis und Myelitis

1867 • 118 citations

Biochemistry and the central nervous system

1958 • 116 citations

The turnover of the lipid components of myelin

1965 • 115 citations

Serotonin Receptors: V, Selective Destruction by Neuraminidase Plus EDTA and Reactivation with Tissue Lipids

1964 • 110 citations

Effects of Epinephrine on Lipid Partition and Metabolism in the Rabbit

1957 • 110 citations

EFFECTS OF CORTICOSTERONE AND FOOD RESTRICTION ON GROWTH AND ON DNA, RNA AND CHOLESTEROL CONTENTS OF THE BRAIN AND LIVER IN INFANT MICE*

1965 • 109 citations

CHANGES IN THE COMPOSITION OF THE DEVELOPING MOUSE BRAIN DURING EARLY MYELINATION*

1958 • 108 citations

Specific inhibition of cholesterol biosynthesis by a synthetic compound (MER-29)

1959 • 103 citations

THE OCCURRENCE OF ESTERIFIED CHOLESTEROL IN THE DEVELOPING NERVOUS SYSTEM

1959 • 95 citations

THE DEPOSITION AND DISPOSAL OF (4‐¹⁴C) CHOLESTEROL IN THE BRAIN OF GROWING CHICKENS

1958 • 94 citations

Metabolism of the Nervous System

1958 • 93 citations

Metabolism of cellular membrane sulpholipids in the rat brain

1966 • 93 citations

Studies on the Biosynthesis of Glycolipides and Other Lipides of the Brain

1959 • 92 citations

The incorporation of 2-C14 mevalonic acid into cholesterol and fatty acids of brain and liver “in vitro”

1959 • 92 citations

The Biology of Mental Health and Disease

1953 • 88 citations

The identification and significance of desmosterol in the developing human and animal brain

1963 • 87 citations

Drugs in the Brain

1961 • 86 citations

Isotopic studies of the biosynthesis of the cerebroside fatty acids in rats

1963 • 82 citations

The human adrenal gland

1961 • 78 citations

Inhibitors of Cholesterol Biosynthesis which Act at or Beyond the Mevalonic Acid Stage

1962 • 77 citations

CHEMICAL AND METABOLIC STUDIES OF RAT MYELIN OF THE CENTRAL NERVOUS SYSTEM^*

1965 • 75 citations

Brain Sterol Metabolism

1965 • 75 citations

LIPIDS IN THE BRAINS OF INFANTS AND CHILDREN

1958 • 74 citations

Influence of the thyroid on the synthesis of cholesterol by liver and skin in vitro

1958 • 72 citations

SYNTHESIS OF LANOSTEROL IN VIVO

1957 • 72 citations

Studies on sulphatases. 23. The enzymic desulphation of tyrosine O-sulphate

1959 • 71 citations

THE RESPIRATORY QUOTIENT OF THE BRAIN

1932 • 71 citations

On the weight of the parts of the brain and on the percentage of water in them according to brain weight and to age, in albino and in wild Norway rats

1931 • 69 citations

METABOLISM OF MYELIN:

1959 • 69 citations

Occurrence of desmosterol in developing rat brain

1962 • 68 citations

The phosphorus metabolism of the brain

1950 • 68 citations

A STUDY OF BRAIN REPAIR IN THE RAT BY THE USE OF TRYPAN BLUE

1920 • 68 citations

THE EFFECT OF FASTING UPON LIPOGENESIS IN THE INTACT RAT

1952 • 65 citations

The ‘Brain’ Hormone in the Silkworm, Bombyx mori L.

1958 • 64 citations

Biosynthesis of Cholesterol

1952 • 64 citations

THE INFLUENCE OF GROWTH AND MYELINATION ON THE DEPOSITION AND METABOLISM OF LIPIDS IN THE BRAIN

1941 • 62 citations

THE BIOLOGICAL CONVERSION OF LANOSTEROL TO CHOLESTEROL

1956 • 62 citations

THE METABOLISM OF β,γ-DIHYDROXY-β-METHYLVALERIC ACID BY LIVER HOMOGENATES

1956 • 61 citations

THE OXYGEN UPTAKE OF ACTIVE AXONS

1952 • 60 citations

Distribution of labeled cholesterol in animal tissues

1962 • 60 citations

Biochemistry and the central nervous system

1956 • 56 citations

Ageing of Nerve Cells

1946 • 52 citations

Incorporation of radioactive phosphate into the nucleic acids of brain slices

1953 • 52 citations

The Cerebral Circulation in Health and Disease

1951 • 51 citations

Thiocyanate space of rat brain

1961 • 49 citations

METABOLISM OF ADIPOSE TISSUE

1954 • 49 citations

LIPID METABOLISM IN BRAIN AND OTHER TISSUES OF THE RAT

1940 • 48 citations

INCORPORATION OF INJECTED CHOLESTEROL INTO THE MYELINATING BRAIN OF THE 17‐DAY‐OLD RABBIT*

1963 • 48 citations

THE CHANGES WITH AGE IN THE PROTEIN COMPOSITION OF THE RAT BRAIN

1956 • 48 citations

Phospholipid metabolism in nervous tissue. 4. Incorporation of 32P into the lipids of subcellular fractions of the brain

1961 • 47 citations

BRAIN CHOLESTEROL: BIOSYNTHESIS WITH SELECTED PRECURSORS IN VIVO

1961 • 47 citations

HISTOCHEMICAL MECHANISMS OF THE MARCHI REACTION FOR DEGENERATING MYELIN

1958 • 47 citations

METABOLISM OF MYELIN LIPIDS: INCORPORATION OF [3‐¹⁴C]SERINE IN BRAIN LIPIDS OF THE DVELOPING RABBIT AND THEIR PERSISTENCE IN THE CENTRAL NERVOUS SYSTEM

1959 • 46 citations

THE BIOLOGICAL SYNTHESIS OF LIPIDS

1948 • 44 citations

The Carbohydrate and Fat Metabolism of Yeast

1926 • 44 citations

Oxidation of cholesterol-26-C14 by rat liver mitochondria: effect of nicotinic acid

1960 • 44 citations

Changes in Nitrogenous Components of Brain Produced by Stimulation of Short Duration

1955 • 43 citations

DISTRIBUTION OF UNSATURATED FATTY ACIDS IN TISSUES

1928 • 42 citations

The sterols of liver and carcass of 20,25-diaza-cholesterol-fed rats

1963 • 42 citations

NEUROTOXICITY OF THE 8-AMINOQUINOLINES

1948 • 42 citations

THE METABOLISM OF CHOLESTEROL AND FATTY ACIDS IN THE CENTRAL NERVOUS SYSTEM*

1959 • 42 citations

Investigation of the biogenetic reaction sequence of cholesterol in rat tissues, through inhibition with AY‐9944

1965 • 42 citations

RADIOACTIVE PHOSPHORUS AS AN INDICATOR OF PHOSPHOLIPID METABOLISM

1938 • 41 citations

Pharmacology of Individual Neurons

1964 • 41 citations

STUDIES OF METABOLIC TURNOVER WITH TRITIUM AS A TRACER

1954 • 40 citations

THE INFLUENCE OF STEROIDS ON CEREBRAL METABOLISM

1951 • 39 citations

THE FORMATION OF PHOSPHOLIPIDS FROM ¹⁴C–LABELLED PRECURSORS IN DEVELOPING RAT BRAIN IN VIVO*

1963 • 38 citations

INHIBITION BY TRIPARANOL OF CHOLESTEROL FORMATION IN THE BRAIN OF THE NEWBORN MOUSE*

1962 • 37 citations

Acquired Adaptation to the Anesthetic Effect of Steroid Hormones

1941 • 37 citations

Agents affecting lipid metabolism—XV. Biochemical studies with the cholesterol biosynthesis inhibitor AY-9944 in young and mature rats

1965 • 37 citations

Persistence of Cholesterol-4-14C in the Central Nervous System

1959 • 37 citations

Desmosterol in developing rat brain

1965 • 35 citations

CONCERNING INCORPORATION OF LABELLED CHOLESTEROL, FED TO THE MOTHERS, INTO BRAIN CHOLESTEROL OF 20‐DAY‐OLD SUCKLING RATS*

1961 • 35 citations

Incorporation of C14 of Acetate-1-C14 and Pyruvate-2-C14 into Brain Cholesterol in the Intact Rat

1957 • 34 citations

CLXXV.—The condensation of acetaldehyde and its relation to the biochemical synthesis of fatty acids

1907 • 34 citations

Oxidation of cholesterol by rat liver mitochondria: effect of dietary fat

1959 • 34 citations

ENDOGENOUS CHOLESTEROL METABOLISM IN THE RAT STUDIED WITH C14-LABELED ACETATE

1954 • 34 citations

Differences in cholesterol oxidation and biosynthesis in liver of male and female rats

1961 • 34 citations

An Analysis of Brain Cholesterol and Fatty Acid Biosynthesis

1958 • 32 citations

THE OXYGEN UPTAKE OF THE PERIPHERAL NERVE OF THE RAT

1957 • 32 citations

THE EFFECT OF HEXOSES AND PENTOSES ON THE FORMATION IN VITRO OF PHOSPHOLIPID BY BRAIN TISSUE AS MEASURED WITH RADIOACTIVE PHOSPHORUS

1942 • 32 citations

A HISTOCHEMICAL CONTRIBUTION TO THE STUDY OF THE MOLECULAR MORPHOLOGY OF MYELIN SHEATH*

1960 • 32 citations

Insulin response of peripheral nerve

1965 • 32 citations

Observations on the development of microglia together with a note on the influence of cortisone.

1955 • 32 citations

THE IN VITRO AND IN VIVO EFFECTS OF CHLORPROMAZINE ON BRAIN LIPID SYNTHESIS

1960 • 31 citations

FACTORS AFFECTING THE INCORPORATION OF RADIOACTIVE PHOSPHATE INTO THE PHOSPHOLIPIDS OF SLICES OF CAT BRAIN

1954 • 30 citations

Some Aspects of Central Nervous Pharmacology

1963 • 29 citations

Phospholipid metabolism in nervous tissue. 1. A reconsideration of brain and peripheral nerve phospholipid metabolism in vivo

1959 • 29 citations

Biosynthesis of Fatty Acids in Liver and Intestine of Intact Normal, Fasted and X-Irradiated Rats

1956 • 27 citations

Substrate Utilization by Stimulated Nerve

1953 • 27 citations

FUNCTIONAL STUDIES OF THE NERVOUS SYSTEM IN EXPERIMENTAL BERIBERI

1935 • 27 citations

Lipid biosynthesis in vivo from acetate-1-C14 and 2-C14 and mevalonic-2-C14 acid

1959 • 27 citations

Effect of 20,25-diazacholesterol and triparanol on sterols particularly desmosterol in rat brain and peripheral tissues

1964 • 26 citations

Weights of various parts of the brain in normal and underfed albino rats at different ages

1918 • 26 citations

Quantitative chemical changes in the human brain during growth

1919 • 25 citations

Effects of electrical pulses on the distribution of radioactive phosphate in cerebral tissues

1956 • 25 citations

GLYCOLYSIS IN THE PARTS OF THE CENTRAL NERVOUS SYSTEM OF CATS AND DOGS DURING GROWTH

1944 • 25 citations

Psychotherapeutic Drugs

1961 • 24 citations

STUDIES ON EPILEPSY

1925 • 23 citations

Influence of sex and sex hormones on the oxidation of cholesterol-26-C14 by rat liver mitochondria

1963 • 23 citations

Central Cholinolytic Action of Chlorpromazine

1962 • 22 citations

C ¹⁴ -Acetate Incorporation into Liver Lipids and Glycogen of Irradiated Rats

1955 • 22 citations

THE FORM IN WHICH CHOLESTEROL OCCURS IN THE ADULT CNS

1960 • 21 citations

Brain cholesterol. XI. A review of biosynthesis in adult mice

1965 • 21 citations

Factors affecting the incorporation of radioactive phosphate into the pentosenucleic acids of brain slices

1953 • 20 citations

NERVE CONDUCTION WITHOUT INCREASED OXYGEN CONSUMPTION: ACTION OF AZIDE AND FLUOROACETATE

1950 • 20 citations

Blood-Brain Barrier and Ground Substance of Central Nervous System

1955 • 20 citations

CONTRIBUTIONS TO THE CHEMICAL DIFFERENTIATION OF THE CENTRAL NERVOUS SYSTEM

1917 • 20 citations

Intracerebral incorporation of [2-14C]mevalonic acid into adult rat brain squalene and cholesteroll

1959 • 19 citations

LIPID BIOSYNTHESIS IN THE CENTRAL NERVOUS SYSTEM IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

1964 • 19 citations

DEPOSITION OF TRITIUM LABELLED STEROLS (CHOLESTEROL, SITOSTEROL, LANOSTEROL) IN BRAIN and OTHER ORGANS OF THE GROWING CHICKEN*

1962 • 18 citations

Cholesterol and mevalonate metabolism: a time course study in vivo

1961 • 18 citations

Exponential Values for the Species-Area Relation

1963 • 17 citations

AN ENZYME HISTOCHEMICAL AND BIOCHEMICAL STUDY OF THE EFFECT OF AN INHIBITOR OF CHOLESTEROL SYNTHESIS ON MYELINATING MOUSE BRAIN†

1964 • 17 citations

EFFECT OF HYPERINSULINISM ON BRAIN PHOSPHOLIPIDE

1951 • 16 citations

Cholesterol synthesis in rat brain: Differential incorporation of mevalonolactone-2-C14 and potassium mevalonate-2-C14

1962 • 15 citations

Function of phospholipids in rececptors

1965 • 14 citations

Tissue distribution of cholesterol and 24-dehydrocholesterol during chronic triparanol therapy

1965 • 14 citations

Brain Cholesterol The Effect of its Development on Incorporation of Acetate-2-3H and Glucose-U-14

1964 • 14 citations

Application of Quantitative Histochemical Methods to the Study of The Nervous System

1955 • 13 citations

CONTRIBUTIONS TO THE CHEMICAL DIFFERENTIATION OF THE CENTRAL NERVOUS SYSTEM

1913 • 13 citations

EMOTIONAL HYPERCHOLESTEROLEMIA

1931 • 13 citations

Untersuchungen zur entwicklungsphysiologie der lipidsynthese

1961 • 13 citations

CHOLESTEROL CONTENT OF SPINAL CORD AND SCIATIC NERVE OF HENS AFTER ORGANOPHOSPHATE AND CARBAMATE ADMINISTRATION

1966 • 13 citations

Cortisol from Human Nerve

1963 • 13 citations

THE EFFECTS OF ADRENALIN, EPHEDRINE, AND INSULIN ON BLOOD FAT

1931 • 13 citations

Effect of X-Ray on Radioactive Phosphorus Turnover and Oxygen Consumption of Brain.

1952 • 12 citations

METABOLISM AND EXCITATION

1936 • 12 citations

Cholesterol turnover in the central nervous system

1965 • 11 citations

Biochemical and physiological differentiation during morphogenesis. XX. In vitro observations on carbohydrate metabolism of the developing cerebral cortex of the fetal guinea pig

1956 • 10 citations

RELATIVE STABILITY OF BRAIN LIPIDS

1958 • 10 citations

Quantitative Gravimetric Fractionation of Brain Tissue

1963 • 10 citations

The age-factor in the brain lesions produced by desoxycorticosterone overdosage.

1949 • 9 citations

Die Wirkung von Schlangengiften auf Nervengewebe

1930 • 9 citations

Phosphate (P32) Exchange in Brain Phospholipids in vivo and in vitro.

1954 • 9 citations

Persistence of Sterols other than Cholesterol in Chicken Tissues

1961 • 9 citations

Inhibition of Cholesterol Synthesis in vivo by a Convulsant, Metrazol.

1964 • 9 citations

THE CORRELATION BETWEEN SEX AND CHEMICAL COMPOSITION OF THE CENTRAL NERVOUS SYSTEM OF WHITE RATS

1941 • 8 citations

Effect of Metrazol on Isolated Mammalian Cells. II. Inhibition of Synthesis of Cholesterol^*

1962 • 8 citations

Zur Abhängigkeit des klonischen Krampfes von der Hirnrinde

1928 • 8 citations

THE EFFECTS OF CONVULSANT AGENTS ON PARTIALLY ISOLATED REGIONS OF THE CENTRAL NERVOUS SYSTEM

1956 • 7 citations

Vegetatives Nervensystem und Blutlipoide

1929 • 7 citations

Experimental Production of Gliosis: I. Effects on the Nervous System of the Rabbit of Intravenous and Intraspinal Injections of Cholesterol Emulsion.

1925 • 6 citations

EXPERIMENTAL INVESTIGATIONS ON CONVULSIONS

1927 • 6 citations

The effect of X-Irradiation and glucose on brain lipid synthesis

1959 • 6 citations

Cerebral Circulation in Health and Disease

1952 • 6 citations

THE DEPOSITION OF LIPIDS IN VARIOUS PARTS OF THE CENTRAL NERVOUS SYSTEM OF THE DEVELOPING RAT

1941 • 5 citations

The effect of insulin on brain cholesterol and fatty acid biosynthesis.

1962 • 5 citations

Brain Cholesterol X: Effect of Scheduling on the Sterol Lowering Capability of Methylphenidate (Ritalin).

1965 • 4 citations

Energy Metabolism

1945 • 4 citations

Increased Concentrations of Blood Lipids in Guinea Pigs poisoned by Sarin

1963 • 4 citations

Brain cholesterol—IX. Effect of methylphenidate on the incorporation of specifically labeled glucose

1965 • 3 citations

Untersuchungen zur Entwicklungsphysiologie des Lipoid-Stoffwechsels in Gehirn und Leber bei Ratten

1963 • 3 citations

INSULIN, CHOLESTEROL, EMOTIONS AND PSYCHOSIS

1941 • 2 citations

Effect of AY-9944, an inhibitor of cholesterol biosynthesis, on the incorporation of lipid precursors in rat tissues

1966 • 2 citations

EXPERIMENTAL PRODUCTION OF CONVULSIVE SEIZURES

1949 • 2 citations

EXPERIMENTAL STUDIES ON GROWTH

1920 • 1 citations

CHICAGO NEUROLOGICAL SOCIETY

1945 • 1 citations