Parkinson’s disease — a multifactorial neurodegenerative disorder

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.

1992 • 9,892 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

1993 • 1,426 citations

Dopamine receptor pharmacology

1994 • 959 citations

A Clinicopathologic Study of 100 Cases of Parkinson's Disease

1993 • 950 citations

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

1995 • 649 citations

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

1984 • 575 citations

Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds

1993 • 541 citations

Possible environmental, occupational, and other etiologic factors for Parkinson's disease

1996 • 424 citations

A large kindred with autosomal dominant Parkinson's disease

1990 • 411 citations

New insights into the cause of Parkinson's disease

1992 • 272 citations

Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.

1994 • 270 citations

Parkinson's disease in twins studied with ¹⁸ F‐dopa and positron emission tomography

1992 • 198 citations

Genetic dissection of Alzheimer disease, a heterogeneous disorder.

1995 • 179 citations

Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease

1997 • 174 citations

Association of a monoamine oxidase B allele with Parkinson's disease

1993 • 163 citations

Decreased tyrosine hydroxylase messenger RNA in the surviving dopamine neurons of the substantia nigra in parkinson's disease: An in situ hybridization study

1990 • 143 citations

Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders

1996 • 127 citations

Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease

1997 • 120 citations

Elevated γ‐aminobutyric acid level in striatal but not extrastriatal brain regions in Parkinson's disease: Correlation with striatal dopamine loss

1986 • 113 citations

Dopamine transporter mutants selectively enhance MPP⁺ transport

1993 • 100 citations

Association of a polymorphism in the dopamine‐transporter gene with parkinson's disease

1997 • 96 citations

Dopamine transporter (DAT) and synaptic vesicle amine transporter (VMAT2) gene expression in the substantia nigra of control and Parkinson's disease

1996 • 93 citations

Evaluation of four candidate genes encoding proteins of the dopamine pathway in familial and sporadic Parkinson's disease

1997 • 80 citations

Genetic linkage studies in autosomal dominant parkinsonism: Evaluation of seven candidate genes

1994 • 77 citations

Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease

1998 • 74 citations

Neurochemical perspectives to the function of monoamine oxidase

1989 • 72 citations

Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes

1997 • 55 citations

Importance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1988 • 55 citations

GABAA Receptor but Not Muscarinic Receptor Density Was Decreased in the Brain of Patients with Parkinson’s Disease

1988 • 54 citations

Neurotensin receptors in parkinson's disease and progressive supranuclear palsy: an autoradiographic study in basal ganglia

1990 • 49 citations

Tyrosine hydroxylase polymorphism in familial and sporadic Parkinson's disease

1994 • 33 citations

Pathogenesis of Idiopathic Parkinsonism

1993 • 30 citations

Heterogeneity of melanized neurons expressing neurotensin receptor messenger RNA in the substantia nigra and the nucleus paranigralis of control and Parkinson's disease brain

1995 • 29 citations

Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease

1997 • 27 citations