Oral Self-Administration of Alcohol: A Valid Approach to the Study of Drug Self-Administration and Human Alcoholism

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

1909 • 6,516 citations

Production of Polydipsia in Normal Rats by an Intermittent Food Schedule

1961 • 720 citations

Genetic Selection for Voluntary Alcohol Consumption in the Albino Rat

1968 • 450 citations

Voluntary ethanol intake in rats following exposure to ethanol on various schedules

1973 • 383 citations

The First Drink

1974 • 378 citations

Advances in Behavioral Pharmacology

2014 • 364 citations

Advances in Behavioral Pharmacology

2014 • 356 citations

Alcoholism and Heredity

1979 • 319 citations

Alcohol and Aldehyde Metabolizing Systems

1977 • 303 citations

Behavioral Maintenance of High Concentrations of Blood Ethanol and Physical Dependence in the Rat

1972 • 268 citations

ANIMAL MODELS IN ALCOHOL RESEARCH

1979 • 255 citations

NEW STRAINS OF RATS WITH ALCOHOL PREFERENCE AND NONPREFERENCE

1977 • 241 citations

Alcohol and Aldehyde Metabolizing Systems-IV

1980 • 241 citations

Criteria for an animal model of alcoholism

1973 • 238 citations

Recent Advances in Studies of Alcoholism

1973 • 227 citations

Zimelidine-induced variations in alcohol intake by nondepressed heavy drinkers

1984 • 226 citations

Ethanol Ingestion: Differences in Blood Acetaldehyde Concentrations in Relatives of Alcoholics and Controls

1979 • 225 citations

Relationship between facial flushing and blood acetaldehyde levels after alcohol intake

1979 • 221 citations

A review of methods to induce alcohol addiction in animals

1973 • 210 citations

Alcohol Taste Thresholds and Concentrations of Solution Preferred by Rats

1940 • 203 citations

Drinking Patterns during Work-Contingent and NonContingent Alcohol Acquisition*

1972 • 202 citations

Development of an Alcohol-Deprivation Effect in Rats

1968 • 201 citations

Action of drugs of abuse on brain reward systems: An update with specific attention to opiates

1982 • 194 citations

Alcohol Sensitivity and Ethnic Background

1974 • 190 citations

Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese

1983 • 168 citations

Ethanol as a reinforcer: Effects of fixed-ratio size and food deprivation

1973 • 138 citations

Roots of behavior

1963 • 136 citations

Self-Maintenance of Intoxication in the Rat

1961 • 117 citations

Alcohol and acetaldehyde metabolism in Caucasians, Chinese and Amerinds.

1976 • 109 citations

Cost Factors Controlling Alcoholic Drinking

1972 • 104 citations

Aldehyde dehydrogenase isozyme variation and alcoholism in Japan

1983 • 103 citations

Ethanol Self-Administration: Infrahuman Studies

1977 • 100 citations

Enzyme activities and ethanol preference in mice

1968 • 98 citations

The Role of Acetaldehyde in Mediating Reactivity to an Acute Dose of Ethanol among Different Racial Groups

1979 • 94 citations

Alteration of fluid preference in ethanol-dependent animals.

1974 • 94 citations

Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats

1978 • 92 citations

Operant Analysis of Drinking Patterns of Chronic Alcoholics

1965 • 81 citations

Alcohol preference in the laboratory rat induced by hypothalamic stimulation

1970 • 77 citations

Intraventricular self-administration of acetaldehyde and voluntary consumption of ethanol in rats

1980 • 75 citations

A comparison of techniques to induce alcohol dependence and tolerance in the mouse.

1972 • 75 citations

Attenuation of ethanol intake by 5-hydroxytryptamine uptake blockade in laboratory rats. I. Involvement of brain 5-hydroxytryptamine in the mediation of the positive reinforcing properties of ethanol.

1979 • 74 citations

Alcohol preference in normal and anosmic rats.

1960 • 72 citations

Effects of Tetraethylthiuramdisulfide (Antabuse) on the Metabolism and Consumption of Ethanol in Mice

1966 • 70 citations

Dissociation between physical dependence and volitional ethanol consumption: Role of multiple withdrawal episodes

1974 • 69 citations

Ethanol intake during schedule-induced polydipsia

1972 • 67 citations

Ethanol as a reinforcer for rats: Effects of concurrent access to water and alternate positions of water and ethanol

1975 • 67 citations

Noradrenergic mediation of the positive reinforcing properties of ethanol: I. Suppression of ethanol consumption in laboratory rats following dopamine-beta-hydroxylase inhibition.

1977 • 66 citations

Schedule-induced consumption of ethanol: Calories or chemotherapy?

1970 • 62 citations

Ethanol intake in the absence of concurrent food reinforcement

1971 • 56 citations

A further investigation of alcohol preference in the laboratory rat induced by hypothalamic stimulation

1971 • 56 citations

Clinical pharmacology and therapeutics

1982 • 53 citations

Rapid establishment of ethanol as a reinforcer for rats

1974 • 52 citations

Rats learning to work for alcohol

1974 • 50 citations

Reluctance of rats to drink hashish suspensions: Free-choice and forced consumption, and the effects of hypothalamic stimulation

1974 • 49 citations

Effects of hypothalamic stimulation, acclimation and periodic withdrawal on ethanol consumption

1972 • 49 citations

Ethanol dependence in the rat: its production and characteristics.

1972 • 48 citations

Brain and liver aldehyde dehydrogenase: Relations to ethanol consumption in wistar rats

1977 • 44 citations

Biological aspects of alcoholism

1997 • 40 citations

Ethanol and Whisky Drinking Patterns in Rats Under Free-Choice and Forced-Choice Conditions

1964 • 37 citations

Ethyl Alcohol Consumption: Valid Measurement in Albino Rats

1968 • 36 citations

Acquisition and Extinction of Schedule-Induced Polydipsic Consumption of Alcohol and Water

1970 • 35 citations

Alcohol Preference in the Rat: Its Relationship to Total Fluid Consumption

1966 • 34 citations

Self-maintenance of intoxication in the rat: A modified replication

1967 • 33 citations

Higher correlation of ethanol consumption with brain than liver aldehyde dehydrogenase in three strains of rats

1984 • 32 citations

Reinforcement with intragastric infusions of ethanol: Blocking effect of FLA 57

1979 • 31 citations

Dietary Deficiency in Mice in Relation to Voluntary Alcohol Consumption

1957 • 31 citations

Changes in learning, extinction, and fluid preferences as a function of chronic alcohol consumption in rats.

1961 • 29 citations

Ethanol ingestion in the rat induced by rewarding brain stimulation

1972 • 29 citations

Alcohol ingestion without oropharyngeal sensations

1969 • 28 citations

Ethanol-reinforced behavior of rats with concurrent access to food and water

1978 • 26 citations

Brain aldehyde dehydrogenase: Adaptive increase following prolonged ethanol administration in rats

1978 • 25 citations

Multiple Factors Affecting Volitional Consumption of Alcohol in the Abrams Wistar Rat

1966 • 23 citations

Effect of Age on Alcohol Preference by Rats

1964 • 23 citations

Ethanol self-administration in water satiated rats

1974 • 23 citations

“Voluntary” Consumption of Alcohol by Rats

1969 • 22 citations

Operant drinking of alcohol on a rate-contingent ratio schedule of reinforcement

1965 • 22 citations

Alcohol Polydipsia in the Rat as a Function of Caloric Need

1972 • 22 citations

A decrease in ethanol preference in rats resulting from forced ethanol drinking under fluid deprivation

1972 • 21 citations

Effect of adaptation to alcohol and of age on voluntary consumption of alcohol by rats

1963 • 20 citations

Temporary effects of periodic alcohol availability

1976 • 19 citations

Marijuana produced changes in cutaneous sensitivity and affect: Users and non-users

1974 • 19 citations

Schedule-induced alcohol ingestion

1970 • 18 citations

The Effect of Ethyl Alcohol on Growth, Fecundity and Voluntary Consumption of Alcohol by Mice

1952 • 17 citations

Ethanol ingestion as an operant response

1967 • 16 citations

The role of physical dependence in animal models of human alcoholism

1976 • 15 citations

The relevance of recent animal studies for the development of treatment procedures for alcoholics

1975 • 15 citations

Electrical stimulation and lesions of the medial forebrain bundle of the rat: Changes in voluntary ethanol consumption and brain aldehyde dehydrogenase activity

1978 • 13 citations

Induced alcohol consumption through positive reinforcement

1968 • 12 citations

Anti-Alcohol Properties of Metronidazole in Rats.

1967 • 12 citations

Ethanol consumption by rats on a differential probability of reinforcement schedule

1970 • 9 citations

Alcohol consumption in domestic and wild rats

1968 • 9 citations

The role of punishment in the aetiology and continuance of alcohol drinking in rats

1967 • 8 citations

Pathological Effects of Prolonged Voluntary Consumption of Alcohol by Mice

1967 • 8 citations

Extinction of alcohol drinking in rats following acquisition on a fixed-ratio schedule of reinforcement

1972 • 8 citations

Reinforcement of ethanol consumption in rats by an increase in the frequency of food-pellet delivery

1971 • 6 citations

Drinking as an avoidance response by the pigtail monkey (Macaca nemestrina).

1973 • 5 citations

The Performance of Adult Alcoholics Working for Alcohol*: A Detailed Operant Analysis

1976 • 5 citations

Drinking as an Avoidance Response by the Pigtail Monkey (Macaca nemestrina)

1973 • 4 citations