CNS immunological modulation of neural graft rejection and survival

Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.

1948 • 1,042 citations

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

1994 • 1,032 citations

Neuropathological Evidence of Graft Survival and Striatal Reinnervation after the Transplantation of Fetal Mesencephalic Tissue in a Patient with Parkinson's Disease

1995 • 857 citations

Immunologically Privileged Sites

1978 • 815 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

Open Microsurgical Autograft of Adrenal Medulla to the Right Caudate Nucleus in Two Patients with Intractable Parkinson's Disease

1987 • 676 citations

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

1993 • 543 citations

Transfer of a foreign gene into the brain using adenovirus vectors

1993 • 538 citations

Central Nervous System Toxicity after Liver Transplantation

1987 • 500 citations

Long-Term Behavioral Recovery in Parkinsonian Rats by an HSV Vector Expressing Tyrosine Hydroxylase

1994 • 333 citations

Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1

1992 • 296 citations

Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis

1988 • 296 citations

Multicenter Study of Autologous Adrenal Medullary Transplantation to the Corpus Striatum in Patients with Advanced Parkinson's Disease

1989 • 291 citations

Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease

1986 • 284 citations

The fate of allogeneic and xenogeneic neuronal tissue transplanted into the third ventricle of rodents

1986 • 284 citations

Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release

1988 • 277 citations

Transplantation in Parkinson's disease: Two cases of adrenal medullary grafts to the putamen

1987 • 273 citations

Cytoimitiunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system

1986 • 250 citations

Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease

1995 • 211 citations

Immunophilins and nervous system

1995 • 195 citations

Cross-species neural grafting in a rat model of Parkinson's disease

1982 • 192 citations

Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons

1985 • 186 citations

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

1987 • 180 citations

Intracerebral xenografts of dopamine neurons: the role of immunosuppression and the blood-brain barrier

1989 • 174 citations

Sertoli Cell-Enriched Fractions in Successful Islet Cell Transplantation

1993 • 172 citations

The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury

1994 • 170 citations

Transplantation of neural tissue in polymer capsules

1988 • 164 citations

Transplantation to the rat brain of human neural progenitors that were genetically modified using adenoviruses

1995 • 160 citations

Massive induction of donor-type class I and class II major histocompatibility complex antigens in rejecting cardiac allografts in the rat.

1985 • 160 citations

Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinsonʼs disease

1994 • 160 citations

Molecular bases of the immune response to neural antigens

1987 • 156 citations

Rejection of fetal neocortical neural transplants by H-2 incompatible mice.

1987 • 149 citations

The immune response to intracerebral neural grafts

1991 • 147 citations

Transplants of immunologically isolated xenogeneic chromaffin cells provide a long-term source of pain-reducing neuroactive substances

1993 • 142 citations

Chapter 24 Survival, growth and function of dopaminergic neurons grafted to the brain

1987 • 127 citations

Survival and growth of fetal catecholamine neurons transplanted into primate brain

1986 • 115 citations

A novel approach to neural transplantation in Parkinson's disease: Use of polymer-encapsulated cell therapy

1992 • 112 citations

Is the Brain "An Immunologically Privileged Site"?

1964 • 109 citations

Immune Response in Deep Cervical Lymph Nodes and Spleen in the Mouse after Antigen Deposition in Different Intracerebral Sites

1988 • 88 citations

Chapter 12 Angiogenesis and the blood-brain barrier in solid and dissociated cell grafts within the CNS

1990 • 66 citations

CENTRAL NERVOUS SYSTEM TOXICITY OF CYCLOSPORINE IN A RAT MODEL

1989 • 56 citations

Survival and immunogenicity of dissociated allogeneic fetal neural dopamine-rich grafts when implanted into the brains of adult mice

1989 • 54 citations

Tissue reaction to intraperitoneal polymer implants: Species difference and effects of corticoid and doxorubicin

1989 • 50 citations

Cellular replacement therapy for neurologic disorders: potential of genetically engineered cells

1991 • 40 citations

BN rats do not reject F344 brain allografts even after systemic sensitization

1991 • 38 citations

Chapter 30 Intraventricular brain allografts and xenografts: studies of survival and rejection with and without systemic sensitization

1988 • 37 citations

Unusual cyclosporin related neurological complications in recipients of liver transplants.

1993 • 33 citations

Fetal Substantia Nigra Transplants Lead to Dopamine Cell Replacement and Behavioral Improvement in Bonnet Monkeys with MPTP Induced Parkinsonism

1988 • 30 citations

Chapter 14 Immune reactions against intracerebral murine xenografts of fetal hippocampal tissue and cultured cortical astrocytes in the adult rat

1990 • 28 citations

Allogeneic grafts of fetal dopamine neurons: Behavioral indices of immunological interactions

1994 • 23 citations

Cyclosporine-A increases spontaneous and dopamine agonist-induced locomotor behavior in normal rats

1995 • 22 citations

The testis: an 'immunologically suppressed' tissue?

1989 • 18 citations

Immunological reactions to neural grafts in the central nervous system

1991 • 14 citations

Cross‐species Grafts of Embryonic Rabbit Mesencephalic Tissue Survive and Cause Behavioral Recovery in the Presence of Chronic Immunosuppression

1987 • 14 citations

Co-Transplantation of Plasmid-Transfected Myoblasts and Myotubes into Rat Brains Enables High Levels of Gene Expression Long-Term

1993 • 14 citations

Sandimmun neoral, a new oral formulation of cyclosporin A with improved pharmacokinetic characteristics: safety and tolerability in renal transplant patients.

1994 • 5 citations

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