Fetal Substantia Nigra Transplants Lead to Dopamine Cell Replacement and Behavioral Improvement in Bonnet Monkeys with MPTP Induced Parkinsonism

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System

1979 • 963 citations

Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants

1979 • 830 citations

Functional Role of the Nigro‐Neostriatal Dopamine Neurons*)

1966 • 394 citations

Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat

1969 • 331 citations

FETAL NEURONAL GRAFTS IN MONKEYS GIVEN METHYLPHENYLTETRAHYDROPYRIDINE

1986 • 243 citations

Intracerebral grafting of neuronal cell suspensions. IV. Behavioural recovery in rats with unilateral 6-OHDA lesions following implantation of nigral cell suspensions in different forebrain sites.

1983 • 225 citations

Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism.

1983 • 199 citations

Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons

1985 • 186 citations

Variability and functional recovery in the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism in monkeys

1986 • 128 citations

Biochemical and Behavioral Correction of MPTP Parkinson‐like Syndrome by Fetal Cell Transplantation^a

1987 • 101 citations

Cross-species transplants of cholinergic neurons and the recovery of function

1985 • 19 citations