Regulation of Dopamine Transporter by Phosphorylation and Impact on Cocaine Action

A psychomotor stimulant theory of addiction.

1987 • 2,704 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

1987 • 2,189 citations

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

The dopamine hypothesis of the reinforcing properties of cocaine

1991 • 990 citations

Cloning and Expression of a Cocaine-Sensitive Rat Dopamine Transporter

1991 • 587 citations

Cloning and Expression of a Cocaine-Sensitive Dopamine Transporter Complementary DNA

1991 • 584 citations

The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons

1996 • 473 citations

Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.

1992 • 467 citations

Multiple Ionic Conductances of the Human Dopamine Transporter: The Actions of Dopamine and Psychostimulants

1997 • 448 citations

Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding.

1992 • 393 citations

Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.

1989 • 389 citations

Protein Kinase C Activation Regulates Human Serotonin Transporters in HEK-293 Cells via Altered Cell Surface Expression

1997 • 377 citations

Cloning and functional characterization of a cocaine‐sensitive dopamine transporter

1991 • 362 citations

Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters.

1994 • 326 citations

Phosphorylation and Regulation of Antidepressant-sensitive Serotonin Transporters

1998 • 312 citations

Protein Kinase C-mediated Phosphorylation and Functional Regulation of Dopamine Transporters in Striatal Synaptosomes

1997 • 298 citations

Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra

1997 • 290 citations

Cloning of the cocaine-sensitive bovine dopamine transporter.

1991 • 261 citations

Molecular Neurobiology of Dopaminergic Receptors

1993 • 251 citations

Neurotransmitter transporters : structure, function, and regulation

2002 • 251 citations

Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium.

1994 • 237 citations

D₂ Receptors May Modulate the Function of the Striatal Transporter for Dopamine: Kinetic Evidence from Studies In Vitro and In Vivo

1993 • 232 citations

A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

1992 • 222 citations

Protein kinase C modulates the activity of a cloned gamma-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter.

1994 • 211 citations

Phorbol Esters Increase Dopamine Transporter Phosphorylation and Decrease Transport V_max

1997 • 187 citations

Activation of protein kinase C inhibits uptake, currents and binding associated with the human dopamine transporter expressed in Xenopus oocytes.

1997 • 186 citations

Nitric oxide inhibits [3H]dopamine uptake

1994 • 175 citations

Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter

1998 • 173 citations

Regulation of the functional activity of the human dopamine transporter by protein kinase C

1997 • 161 citations

Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins.

1998 • 157 citations

Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices.

1998 • 151 citations

Phorbol esters alter functions of the expressed dopamine transporter

1994 • 118 citations

Protein kinase C and dopamine transport—2. Effects of amphetamine in vitro

1992 • 104 citations

Nature of methamphetamine-induced rapid and reversible changes in dopamine transporters

1998 • 102 citations

Dopamine transporter mutants selectively enhance MPP⁺ transport

1993 • 100 citations

Protein kinase C activators decrease dopamine uptake into striatal synaptosomes.

1996 • 99 citations

Protein Kinase A Activity May Kinetically Upregulate the Striatal Transporter for Dopamine

1998 • 98 citations

Modulation of a Recombinant Glycine Transporter (GLYT1b) by Activation of Protein Kinase C

1995 • 96 citations

Phosphorylation of a Vesicular Monoamine Transporter by Casein Kinase II

1997 • 73 citations

Dopamine Transporter Ligand Binding Domains

1996 • 71 citations

Differential Binding of Tropane-Based Photoaffinity Ligands on the Dopamine Transporter

1999 • 71 citations

Effects of Arachidonic Acid on Dopamine Synthesis, Spontaneous Release, and Uptake in Striatal Synaptosomes from the Rat

1995 • 70 citations

Dopamine transport sites selectively labeled by a novel photoaffinity probe: 125I-DEEP

1989 • 68 citations

Human and mouse dopamine transporter genes: conservation of 5′-flanking sequence elements and gene structures

1995 • 67 citations

The Structure and Function of Norepinephrine, Dopamine, and Serotonin Transporters

1997 • 64 citations

Regulation of the functional activity of the human dopamine transporter by the arachidonic acid pathway

1996 • 63 citations

Photoaffinity-labeled ligand binding domains on dopamine transporters identified by peptide mapping.

1995 • 61 citations

Dopamine transporter: deglycosylation with exo- and endoglycosidases

1991 • 48 citations

A putative model of the dopamine transporter

1994 • 47 citations

Dopamine and γ-aminobutyric acid transporters: Differential regulation by agents that promote phosphorylation

1994 • 44 citations

Ca²⁺‐Dependent Enhancement of [³H]Dopamine Uptake in Rat Striatum: Possible Involvement of Calmodulin‐Dependent Kinases

1995 • 40 citations

β-Adrenergic receptor-coupled adenylate cyclase

1987 • 33 citations

Activation of D₁ and D₂ Dopamine Receptors Inhibits Protein Kinase C Activity in Striatal Synaptoneurosomes

1994 • 32 citations

Cloned Sodium- (and Chloride-) Dependent High-Affinity Transporters for GABA, Glycine, Proline, Betaine, Taurine, and Creatine

1997 • 31 citations

β-Adrenergic Receptor-Coupled Adenylate Cyclase

1988 • 25 citations

Photoaffinity labeling of the dopamine reuptake carrier protein with 3-azido[3H]GBR-12935.

1991 • 24 citations

The effects of phosphorylation on the functional regulation of an expressed recombinant human dopamine transporter

1996 • 21 citations

[3H]WIN 35,428 ([3H]CFT) binds to multiple charge-states of the solubilized dopamine transporter in primate striatum.

1995 • 19 citations

Vesicular Neurotransmitter Transporters*: Pharmacology, Biochemistry, and Molecular Analysis

2003 • 18 citations

Dopamine transporter: Solubilization from dog caudate nucleus

1989 • 15 citations

Okadaic acid modulates exocytotic and transporter-dependent release of dopamine in bovine retina in vitro

1995 • 15 citations

Neurotransmitter Transporter Proteins

1997 • 7 citations

Dopamine Transporter — Cocaine Receptor: Characterization and Purification

1991 • 2 citations