3 Intrasteric regulation of protein kinases

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Solvation energy in protein folding and binding

1986 • 1,853 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues.

1975 • 758 citations

Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3‘:5‘-monophosphate-dependent protein kinase.

1978 • 467 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans

1989 • 368 citations

Calmodulin binding domains: characterization of a phosphorylation and calmodulin binding site from myosin light chain kinase

1986 • 319 citations

Isolation and properties of the rabbit skeletal muscle protein inhibitor of adenosine 3',5'-monophosphate dependent protein kinases

1977 • 264 citations

The multifunctional Ca2+/calmodulin-dependent protein kinases

1993 • 251 citations

The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence.

1987 • 241 citations

Regulatory and structural motifs of chicken gizzard myosin light chain kinase.

1990 • 208 citations

Titin and nebulin: protein rulers in muscle?

1994 • 202 citations

A template for the protein kinase family

1993 • 196 citations

Insights into autoregulation from the crystal structure of twitchin kinase

1994 • 192 citations

Intrasteric regulation of protein kinases and phosphatases

1991 • 151 citations

X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 Å resolution

1992 • 146 citations

Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain.

1987 • 122 citations

Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegans.

1993 • 116 citations

Giant protein kinases: domain interactions and structural basis of autoregulation.

1996 • 92 citations

Spatial requirements for location of basic residues in peptide substrates for smooth muscle myosin light chain kinase.

1985 • 88 citations

Giant protein kinases: domain interactions and structural basis of autoregulation.

1996 • 87 citations

Immunoglobulin-Type Domains of Titin: Same Fold, Different Stability?

1994 • 82 citations

Solution structure of the cAMP-dependent protein kinase catalytic subunit and its contraction upon binding the protein kinase inhibitor peptide

1993 • 73 citations

2.0 Å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent

1993 • 73 citations

Autophosphorylation of molluscan twitchin and interaction of its kinase domain with calcium/calmodulin.

1994 • 61 citations

Commentary on ‘The phosphorylase b to a converting enzyme of rabbit skeletal muscle’ by E.G. Krebs and E.H. Fischer Biochim. Biophys. Acta 20 (1956) 150–157

1989 • 59 citations

Bovine brain adenosine 3',5'-monophosphate dependent protein kinase. Mechanism of regulatory subunit inhibition of the catalytic subunit

1975 • 55 citations

Protein kinase domain of twitchin has protein kinase activity and an autoinhibitory region.

1994 • 49 citations

Phosphorylation of Myosin Regulatory Light Chains by the Molluscan Twitchin Kinase

1995 • 44 citations

Intrasteric Regulation of Calmodulin-Dependent Protein Kinases

1996 • 9 citations

Activation mechanism of rabbit skeletal muscle myosin light chain kinase 5′‐p‐Fluorosulfonylbenzoyl adenosine as a probe of the MgATP‐binding site of the calmodulin‐bound and calmodulin‐free enzyme

1991 • 9 citations

Crystallization and preliminary x-ray analysis of the auto-inhibited twitchin kinase

1994 • 8 citations

Molecular Characterization of Cyclic AMP-Dependent Protein Kinases Derived from Bovine Heart and Human Erythrocytes

1974 • 5 citations