Acute Coronary Syndrome

Heart rate variability: Standards of measurement, physiological interpretation, and clinical use

1996 • 14,140 citations

ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary

2004 • 8,563 citations

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

2008 • 6,182 citations

Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond

2007 • 5,803 citations

ACC/AHA Guidelines for the Management of Patients With Unstable Angina and Non–ST-Segment Elevation Myocardial Infarction: Executive Summary and Recommendations

2000 • 4,662 citations

Universal Definition of Myocardial Infarction

2007 • 4,159 citations

Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein

2009 • 3,737 citations

Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction

2007 • 3,183 citations

The TIMI Risk Score for Unstable Angina/Non–ST Elevation MI

2000 • 3,097 citations

Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction

1998 • 3,050 citations

Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock

1999 • 2,805 citations

The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina

1994 • 2,343 citations

C-Reactive Protein Levels and Outcomes after Statin Therapy

2005 • 2,249 citations

Comparison of Early Invasive and Conservative Strategies in Patients with Unstable Coronary Syndromes Treated with the Glycoprotein IIb/IIIa Inhibitor Tirofiban

2001 • 2,126 citations

Genomewide Association Analysis of Coronary Artery Disease

2007 • 2,027 citations

Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: The Task Force for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of the European Society of Cardiology

2007 • 1,888 citations

ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

2007 • 1,887 citations

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

2008 • 1,696 citations

A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction

2007 • 1,588 citations

Early Diagnosis of Myocardial Infarction with Sensitive Cardiac Troponin Assays

2009 • 1,582 citations

A Validated Prediction Model for All Forms of Acute Coronary Syndrome

2004 • 1,536 citations

A Common Allele on Chromosome 9 Associated with Coronary Heart Disease

2007 • 1,532 citations

TIMI Risk Score for ST-Elevation Myocardial Infarction: A Convenient, Bedside, Clinical Score for Risk Assessment at Presentation

2000 • 1,466 citations

ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

2007 • 1,463 citations

American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death

2008 • 1,403 citations

The Prognostic Value of B-Type Natriuretic Peptide in Patients with Acute Coronary Syndromes

2001 • 1,306 citations

Cardiac Troponin T Levels for Risk Stratification in Acute Myocardial Ischemia

1996 • 1,129 citations

Sensitive Troponin I Assay in Early Diagnosis of Acute Myocardial Infarction

2009 • 1,114 citations

Criteria for Evaluation of Novel Markers of Cardiovascular Risk

2009 • 1,070 citations

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death

2006 • 1,051 citations

ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary

2004 • 989 citations

Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study

2008 • 970 citations

Scientific Evidence Underlying the ACC/AHA Clinical Practice Guidelines

2009 • 910 citations

Statistical Evaluation of Prognostic versus Diagnostic Models: Beyond the ROC Curve

2007 • 663 citations

Cytochrome P450 Genetic Polymorphisms and the Response to Prasugrel

2009 • 645 citations

A Randomized Controlled Trial of Multi-Slice Coronary Computed Tomography for Evaluation of Acute Chest Pain

2007 • 633 citations

Biomarkers in Acute Cardiac Disease

2006 • 630 citations

N -Terminal Pro–Brain Natriuretic Peptide and Other Risk Markers for the Separate Prediction of Mortality and Subsequent Myocardial Infarction in Patients With Unstable Coronary Artery Disease

2003 • 597 citations

Deceleration capacity of heart rate as a predictor of mortality after myocardial infarction: cohort study

2006 • 591 citations

Elevated Levels of C-Reactive Protein at Discharge in Patients With Unstable Angina Predict Recurrent Instability

1999 • 583 citations

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes

2007 • 576 citations

Prognostic Value of the Admission Electrocardiogram in Acute Coronary Syndromes

1999 • 554 citations

Benefit of Early Invasive Therapy in Acute Coronary Syndromes

2006 • 548 citations

Coronary Computed Tomography Angiography for Early Triage of Patients With Acute Chest Pain

2009 • 547 citations

Early Invasive versus Selectively Invasive Management for Acute Coronary Syndromes

2005 • 543 citations

Delayed Enhancement and T2-Weighted Cardiovascular Magnetic Resonance Imaging Differentiate Acute From Chronic Myocardial Infarction

2004 • 526 citations

Noninvasive Coronary Artery Imaging

2008 • 450 citations

Heart Rate Turbulence: Standards of Measurement, Physiological Interpretation, and Clinical Use

2008 • 443 citations

Diagnostic Performance of Multidetector CT Angiography for Assessment of Coronary Artery Disease: Meta-analysis

2007 • 437 citations

Evaluation of B-type natriuretic peptide for risk assessment in unstable Angina/Non–ST-elevation myocardial infarction

2003 • 429 citations

American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death

2008 • 419 citations

Predictive value of C-reactive protein and troponin T in patients with unstable angina: a comparative analysis

2000 • 414 citations

The prognostic value of troponin in patients with non-ST elevation acute coronary syndromes: a meta-analysis

2001 • 396 citations

Coronary Multidetector Computed Tomography in the Assessment of Patients With Acute Chest Pain

2006 • 366 citations

64-multislice detector computed tomography coronary angiography as potential alternative to conventional coronary angiography: a systematic review and meta-analysis

2007 • 358 citations

Detecting Acute Coronary Syndrome in the Emergency Department With Cardiac Magnetic Resonance Imaging

2003 • 357 citations

The Electrocardiogram Predicts One-Year Outcome of Patients With Unstable Angina and Non–Q Wave Myocardial Infarction: Results of the TIMI III Registry ECG Ancillary Study fn1fn1The TIMI III Clinical Centers are supported by Grant R01-HL42311 and the Data Coordinating Center by Grant R01-HL42428 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. Additional support was supplied by Genentech, Inc., South San Francisco, California.

1997 • 357 citations

Myocardial Perfusion Imaging for Evaluation and Triage of Patients With Suspected Acute Cardiac Ischemia

2002 • 357 citations

Prognostic Value of Growth-Differentiation Factor-15 in Patients With Non–ST-Elevation Acute Coronary Syndrome

2007 • 354 citations

Complementary Roles for Biomarkers of Biomechanical Strain ST2 and N-Terminal Prohormone B-Type Natriuretic Peptide in Patients With ST-Elevation Myocardial Infarction

2008 • 313 citations

Clinical Relevance of C-Reactive Protein During Follow-Up of Patients With Acute Coronary Syndromes in the Aggrastat-to-Zocor Trial

2006 • 303 citations

Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury

2008 • 272 citations

Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35

2008 • 270 citations

Risk scores for risk stratification in acute coronary syndromes: useful but simpler is not necessarily better

2007 • 261 citations

Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction

2008 • 257 citations

The ABCD (Alternans Before Cardioverter Defibrillator) Trial

2009 • 253 citations

Prognostic Impact of Early ST-Segment Resolution in Acute ST-Elevation Myocardial Infarction

2004 • 240 citations

An integrated clinical approach to predicting the benefit of tirofiban in non-ST elevation acute coronary syndromes. Application of the TIMI Risk Score for UA/NSTEMI in PRISM-PLUS

2002 • 234 citations

Combined assessment of T-wave alternans and late potentials used to predict arrhythmic events after myocardial infarction

2000 • 231 citations

Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T

2008 • 226 citations

Prognostic Value of Serial B-Type Natriuretic Peptide Testing During Follow-up of Patients With Unstable Coronary Artery Disease

2005 • 226 citations

Growth Differentiation Factor 15 for Risk Stratification and Selection of an Invasive Treatment Strategy in Non–ST-Elevation Acute Coronary Syndrome

2007 • 222 citations

Does Microvolt T-Wave Alternans Testing Predict Ventricular Tachyarrhythmias in Patients With Ischemic Cardiomyopathy and Prophylactic Defibrillators?

2008 • 210 citations

B-type natriuretic peptide at presentation and prognosis in patients with ST-segment elevation myocardial infarction

2004 • 208 citations

Earlier Detection of Myocardial Injury in a Preliminary Evaluation Using a New Troponin I Assay With Improved Sensitivity

2007 • 206 citations

Angiographic Findings in Patients With Refractory Unstable Angina According to Troponin T Status

1999 • 206 citations

Metabolic Imaging With β-Methyl- p -[ ¹²³ I]-Iodophenyl-Pentadecanoic Acid Identifies Ischemic Memory After Demand Ischemia

2005 • 201 citations

Ambulatory Electrocardiogram‐Based Tracking of T Wave Alternans in Postmyocardial Infarction Patients to Assess Risk of Cardiac Arrest or Arrhythmic Death

2003 • 182 citations

Myocardial Ischemic Memory Imaging With Molecular Echocardiography

2007 • 159 citations

The clinical need for high-sensitivity cardiac troponin assays for acute coronary syndromes and the role for serial testing

2007 • 156 citations

Development and Preliminary Clinical Validation of a High Sensitivity Assay for Cardiac Troponin Using a Capillary Flow (Single Molecule) Fluorescence Detector

2006 • 143 citations

Detection of recent myocardial ischaemia by molecular imaging of P-selectin with targeted contrast echocardiography

2007 • 139 citations

Implication of different cardiac troponin I levels for clinical outcomes and prognosis of acute chest pain patients

2004 • 139 citations

Elevated Troponin T Levels and Lesion Characteristics in Non–ST-Elevation Acute Coronary Syndromes

2004 • 132 citations

Assessing New Biomarkers and Predictive Models for Use in Clinical Practice

2008 • 131 citations

Understanding Physicians' Risk Stratification of Acute Coronary Syndromes

2009 • 128 citations

N-terminal pro-brain natriuretic peptide in relation to inflammation, myocardial necrosis, and the effect of an invasive strategy in unstable coronary artery disease

2003 • 128 citations

Extent of ST-segment deviation in a single electrocardiogram lead 90 min after thrombolysis as a predictor of medium-term mortality in acute myocardial infarction

2001 • 124 citations

Serial analyses of N-terminal pro-B-type natriuretic peptide in patients with non–ST-segment elevation acute coronary syndromes

2005 • 124 citations

A Multinational Study to Establish the Value of Early Adenosine Technetium-99m Sestamibi Myocardial Perfusion Imaging in Identifying a Low-Risk Group for Early Hospital Discharge After Acute Myocardial Infarction

2006 • 123 citations

Troponin-T and N-Terminal Pro-B-Type Natriuretic Peptide Predict Mortality Benefit From Coronary Revascularization in Acute Coronary Syndromes

2006 • 114 citations

Admission Troponin T Level Predicts Clinical Outcomes, TIMI Flow, and Myocardial Tissue Perfusion After Primary Percutaneous Intervention for Acute ST-Segment Elevation Myocardial Infarction

2001 • 106 citations

Single-Point Cardiac Troponin T at Coronary Care Unit Discharge after Myocardial Infarction Correlates with Infarct Size and Ejection Fraction

2002 • 103 citations

Use of Cardiovascular Magnetic Resonance Imaging in Acute Coronary Syndromes

2009 • 100 citations

Prognostic Value of a Normal or Nonspecific Initial Electrocardiogram in Acute Myocardial Infarction

2001 • 97 citations

Methods and Limitations of Assessing New Noninvasive Tests

2008 • 90 citations

Short- and Long-Term Risk Stratification in Acute Coronary Syndromes

2006 • 80 citations

Clinical Application of C-Reactive Protein Across the Spectrum of Acute Coronary Syndromes

2007 • 75 citations

Growth-differentiation factor-15 for early risk stratification in patients with acute chest pain

2008 • 71 citations

Use of Cardiac Catheterization for Non–ST-Segment Elevation Acute Coronary Syndromes According to Initial Risk<subtitle>Reasons Why Physicians Choose Not to Refer Their Patients</subtitle>

2008 • 70 citations

Concentrations of C-Reactive Protein and B-Type Natriuretic Peptide 30 Days after Acute Coronary Syndromes Independently Predict Hospitalization for Heart Failure and Cardiovascular Death

2008 • 58 citations

Ischemia Detected on Continuous Electrocardiography After Acute Coronary Syndrome

2009 • 57 citations

Comparison of a 60- versus 90-minute determination of ST-segment resolution after thrombolytic therapy for acute myocardial infarction

2000 • 51 citations

Comparison of Value of Leads from Body Surface Maps to 12-Lead Electrocardiogram for Diagnosis of Acute Myocardial Infarction

2008 • 34 citations