Heart Rate Turbulence: Standards of Measurement, Physiological Interpretation, and Clinical Use
Data up to Jan 2025
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Abstract
References (274)
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Clinical, hemodynamic and sympathetic neural correlates of heart rate variability in congestive heart failure
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Evidence for an intrinsic mechanism regulating heart rate variability in the transplanted and the intact heart during submaximal dynamic exercise?
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Impaired circadian modulation of sympathovagal activity in diabetes. A possible explanation for altered temporal onset of cardiovascular disease.
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Heart rate turbulence-based predictors of fatal and nonfatal cardiac arrest (The autonomic tone and reflexes after myocardial infarction substudy)
2002 • 236 citations
Sustained augmentation of parasympathetic tone with angiotensin-converting enzyme inhibition in patients with congestive heart failure
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Time course of recovery of heart period variability after myocardial infarction
1991 • 228 citations
Power spectrum analysis of heart rate variability in human cardiac transplant recipients.
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Twenty four hour heart rate variability: effects of posture, sleep, and time of day in healthy controls and comparison with bedside tests of autonomic function in diabetic patients.
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Classification of deaths after myocardial infarction as arrhythmic or nonarrhythmic (The Cardiac Arrhythmia Pilot Study)
1989 • 215 citations
Reproducibility and relation to mean heart rate of heart rate variability in normal subjects and in patients with congestive heart failure secondary to coronary artery disease
1991 • 207 citations
Spinal sympathetic reflexes initiated by coronary receptors
1971 • 205 citations
Relaxation of the ACh-induced potassium current in the rabbit sinoatrial node cell
1978 • 200 citations
Effects of beta blockers (atenolol or metoprolol) on heart rate variability after acute myocardial infarction
1994 • 199 citations
Complex heart rate variability and serum norepinephrine levels in patients with advanced heart failure
1994 • 197 citations
Decreased cardiac parasympathetic activity in chronic heart failure and its relation to left ventricular function.
1992 • 194 citations
Reduced sinus arrhythmia in diabetic autonomic neuropathy: diagnostic value of an age-related normal range.
1982 • 191 citations
Circadian rhythm of heart rate variability after acute myocardial infarction and its influence on the prognostic value of heart rate variability
1990 • 187 citations
Single cardiac vagal fiber activity, acute myocardial ischemia, and risk for sudden death.
1991 • 187 citations
Power Spectral Analysis of Heart-Rate Variations Improves Assessment of Diabetic Cardiac Autonomic Neuropathy
1992 • 186 citations
Heart rate variability from 24-hour electrocardiography and the 2-year risk for sudden death.
1993 • 185 citations
Autonomic indexes based on the analysis of heart rate variability: a view from the sinus node
2001 • 182 citations
Circadian rhythm of heart rate variability in survivors of cardiac arrest
1992 • 179 citations
Muscarinic control of the hyperpolarization‐activated current (if) in rabbit sino‐atrial node myocytes.
1988 • 178 citations
Spectral Analysis of Heart Rate in Diabetic Autonomic Neuropathy
1991 • 174 citations
Sympathetic nervous system and cardiac arrhythmias
1990 • 170 citations
Reduced parasympathetic cardiac control in patients with hypertension at rest and under mental stress
1994 • 170 citations
Stability over time of heart period variability in patients with previous myocardial infarction and ventricular arrhythmias
1992 • 147 citations
Reflex versus tonic vagal activity as a prognostic parameter in patients with sustained ventricular tachycardia or ventricular fibrillation.
1994 • 147 citations
Efficient estimation of the heart period power spectrum suitable for physiologic or pharmacologic studies
1990 • 146 citations
Relation of heart rate and blood pressure turbulence following premature ventricular complexes to baroreflex sensitivity in chronic congestive heart failure
2001 • 143 citations
Mechanisms controlling cardiac autonomic function and their relation to arrhythmogenesis
1986 • 142 citations
Heart rate variability in patients with ventricular arrhythmias: Effect of antiarrhythmic drugs
1991 • 141 citations
Prognostic value and physiological correlates of heart rate variability in chronic severe mitral regurgitation.
1993 • 135 citations
Circadian variation of spectral indices of heart rate variability after myocardial infarction
1992 • 132 citations
Positive Chronotropic Effect of Increasing Right Atrial Pressure in the Isolated Mammalian Heart
1956 • 128 citations
Altered pattern of circadian neural control of heart period in mild hypertension
1991 • 126 citations
Clinical Guide to Cardiac Autonomic Tests
1998 • 120 citations
Assessment of heart rate variability in hypertrophic cardiomyopathy. Association with clinical and prognostic features.
1993 • 117 citations
Dynamic Electrocardiography
2004 • 116 citations
Comparison of heart rate variability in survivors and nonsurvivors of sudden cardiac arrest
1992 • 114 citations
Blunted arterial baroreflex causes “pathological” heart rate turbulence
2000 • 112 citations
Heart rate variability for risk stratification of life-threatening arrhythmias
1993 • 111 citations
Heart rate turbulence predicts all-cause mortality and sudden death in congestive heart failure patients
2008 • 109 citations
Assessment of autonomic response by broad-band respiration
1989 • 108 citations
Tight Mechanism Correlation Between Heart Rate Turbulence and Baroreflex Sensitivity: Sequential Autonomic Blockade Analysis
2002 • 108 citations
Evaluation of Heart-Rate Turbulence as a New Prognostic Marker in Patients With Chronic Heart Failure.
2002 • 105 citations
Effects of Ventricular Premature Stimulus Coupling Interval on Blood Pressure and Heart Rate Turbulence
2002 • 105 citations
Low doses of scopolamine increase cardiac vagal tone in the acute phase of myocardial infarction.
1993 • 104 citations
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1992 • 100 citations
Scopolamine increases vagal tone and vagal reflexes in patients after myocardial infarction
1993 • 100 citations
Power spectral analysis of heart rate variability in traumatic quadriplegic humans
1990 • 99 citations
Enhancement of sympathetic nerve activity by single premature ventricular beats in humans
1989 • 98 citations
Spectral analysis of heart rate variability following human heart transplantation: evidence for functional reinnervation
1988 • 96 citations
Scopolamine improves autonomic balance in advanced congestive heart failure.
1994 • 94 citations
Spectral analysis of heart rate variability signal and respiration in diabetic subjects
1990 • 91 citations
Responses of the Sino-atrial Node to Change in Pressure in the Sinus Node Artery
1967 • 89 citations
Prognostic value of heart rate variability after myocardial infarction. A comparison of different data-processing methods
1989 • 89 citations
Assessment of autonomic regulation of heart rate variability by the method of complex demodulation
1989 • 88 citations
Heart rate turbulence
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Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction
2005 • 85 citations
Do Increases in Markers of Vagal Activity Imply Protection From Sudden Death?
1995 • 85 citations
Effects of metoprolol on heart rate variability in survivors of acute myocardial infarction
1993 • 84 citations
Heart rate turbulence: A 5-year review
2004 • 84 citations
Time-domain system for assessing variation in heart rate
1988 • 84 citations
Prognostic Significance of Heart Rate Turbulence Following Ventricular Premature Beats in Patients with Idiopathic Dilated Cardiomyopathy
2003 • 84 citations
Heart Rate Variability and Heart Rate Turbulence in Patients With Type 2 Diabetes Mellitus With Versus Without Cardiac Autonomic Neuropathy
2007 • 82 citations
Temporal changes and prognostic significance of measures of heart rate dynamics after acute myocardial infarction in the beta-blocking era
2003 • 81 citations
Conventional heart rate variability analysis of ambulatory electrocardiographiic recording fails to predict imminent ventricular fibrillation
1993 • 79 citations
On the kinetics of the potassium channel activated by acetylcholine in the S-A node of the rabbit heart
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Effect of stretch on the isolated cat sinoatrial node
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Effects of localized stretch of the sinoatrial node region of the dog heart
1966 • 78 citations
Influences of neural mechanisms on heart period and arterial pressure variabilities in quadriplegic patients
1994 • 78 citations
Effect of atropine on heart rate turbulence
2002 • 73 citations
Influence of the recognition artefact in automatic analysis of long-term electrocardiograms on time-domain measurement of heart rate variability
1993 • 66 citations
ANGINA PECTORIS FOLLOWING A CRUSHING ACCIDENT
1939 • 66 citations
Relationships between beat-to-beat interval and the strength of contraction in the healthy and diseased human heart.
1984 • 64 citations
A phenomenon of heart-rate turbulence, its evaluation, and prognostic value.
2002 • 63 citations
Effects of low dose transdermal scopolamine on heart rate variability in acute myocardial infarction
1993 • 62 citations
Heart-rate spectral analysis: A noninvasive probe of cardiovascular regulation in critically ill children with heart disease
1988 • 62 citations
Risk Stratification Using Heart Rate Turbulence and Ventricular Arrhythmia in MADIT II: Usefulness and Limitations of a 10‐Minute Holter Recording
2004 • 58 citations
Heart rate turbulence and death due to cardiac decompensation in patients with chronic heart failure
2006 • 57 citations
Influence of transdermal scopolamine on cardiac sympathovagal interaction after acute myocardial infarction
1993 • 57 citations
A reflex increase in heart rate from distension of the junction between the superior vena cava and the right atrium
1972 • 56 citations
Sympathetic neural modulation of cardiac impulse initiation and repolarization in the newborn rat.
1990 • 55 citations
FURTHER STUDIES ON THE PHYSIOLOGY OF HEART-BLOCK IN MAMMALS
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QRS duration and late mortality in unselected post-infarction patients of the revascularization era
2005 • 54 citations
Postextrasystolic regulation patterns of blood pressure and heart rate in patients with idiopathic dilated cardiomyopathy
2002 • 54 citations
The accuracy of power-spectrum analysis of heart-rate variability from annotated RR lists generated by Holter systems
1994 • 54 citations
Unexpected interaction between beta-adrenergic blockade and heart rate variability before and after myocardial infarction. A longitudinal study in dogs at high and low risk for sudden death.
1994 • 54 citations
Significance of long term components of heart rate variability for the further prognosis after acute myocardial infarction
1990 • 53 citations
Impaired cardiac autonomic nervous activity predicts sudden cardiac death in patients with operated and unoperated congenital cardiac disease
2006 • 52 citations
Reflex Cardiac Activity in Ischemia and Reperfusion
2003 • 50 citations
Heart Rate Turbulence, Depression, and Survival After Acute Myocardial Infarction
2006 • 50 citations
Beta-blocking effect of propafenone based on spectral analysis of heart rate variability
1992 • 49 citations
Regular physical exercise, heart rate variability and turbulence in a 6-year randomized controlled trial in middle-aged men: The DNASCO study
2005 • 48 citations
Relationship Between Heart Rate Turbulence and Heart Rate, Heart Rate Variability, and Number of Ventricular Premature Beats in Coronary Patients
2004 • 48 citations
Hemodynamics and Autonomic Control of Heart Rate Turbulence
2005 • 46 citations
Increased myocardial vulnerability and autonomic nervous system imbalance in obstructive sleep apnea syndrome
2006 • 46 citations
Diurnal variations of neurocardiac rhythms in acute myocardial infarction
1991 • 45 citations
Physiology of the Cardiac Autonomic System
1998 • 45 citations
Relation of Heart Rate Turbulence to Severity of Heart Failure
2006 • 45 citations
Cardiac vagal activity, myocardial ischemia and sudden death
1995 • 45 citations
Responses of sympathetic nerves to programmed ventricular stimulation
1987 • 44 citations
The effect on heart rate of distending the atrial appendages in the dog
1972 • 44 citations
Mechanisms involved in heart rate turbulence.
2002 • 44 citations
Predicting mortality after myocardial infarction from the response of RR variability to antiarrhythmic drug therapy
1994 • 43 citations
Heart Rate Turbulence following Ventricular Premature Beats in Healthy Controls
2003 • 43 citations
The 24-hour heart rate behavior in long-term survivors of cardiac transplantation
1988 • 43 citations
HEART-BLOCK
1918 • 42 citations
Heart rate turbulence after atrial premature beats before spontaneous onset of atrial fibrillation
2005 • 42 citations
Heart block
1944 • 42 citations
Abnormal Heart Rate Turbulence Predicts the Initiation of Ventricular Arrhythmias
2005 • 41 citations
Heart Rate Turbulence and Clinical Prognosis in Hypertrophic Cardiomyopathy and Myocardial Infarction
2003 • 41 citations
Heart rate variability and turbulence in hyperthyroidism before, during, and after treatment
2004 • 40 citations
Heart Rate Turbulence after Ventricular and Atrial Premature Beats in Subjects without Structural Heart Disease
2003 • 39 citations
The mechanism of irregular sinus rhythm in auriculoventricular heart block
1948 • 38 citations
Turbulence dynamics: An independent predictor of late mortality after acute myocardial infarction
2005 • 38 citations
Effects of Changes in Intraluminal Pressure on Inotropic and Chronotropic Responses of Isolated Mammalian Hearts
1958 • 37 citations
Effect of quinapril on blood pressure and heart rate in congestive heart failure
1992 • 37 citations
Characteristics of heart beat intervals and prediction of death
2004 • 36 citations
Influence of obstructive sleep apnea on heart rate turbulence
2005 • 36 citations
Assessment of Heart Rate Turbulence in the Acute Phase of Myocardial Infarction for Long‐Term Prognosis
2003 • 36 citations
Restoration of Heart Rate Turbulence by Titrated Beta‐Blocker Therapy in Patients with Advanced Congestive Heart Failure:
2004 • 34 citations
Changes in Autonomic Tone Following Thrombolytic Therapy for Acute Myocardial Infarction:
1994 • 34 citations
Heart Rate Turbulence in Chagas Disease
2003 • 32 citations
Induction of heart rate and blood pressure turbulence in the electrophysiologic laboratory
2002 • 31 citations
Association of the Heart Rate Turbulence with Classic Risk Stratification Parameters in Postmyocardial Infarction Patients
2003 • 31 citations
Premature ventricular contractions and reflex sympathetic activation in cats
1989 • 30 citations
Impact of Age and Basic Heart Rate on Heart Rate Turbulence in Healthy Persons
2005 • 30 citations
Heart rate turbulence and other autonomic risk markers for arrhythmia risk stratification in dilated cardiomyopathy
2008 • 30 citations
Heart Rate Turbulence After Atrial and Ventricular Premature Beats: Relation to Left Ventricular Function and Coupling Intervals
2003 • 30 citations
Sympathetic Response to Ventricular Extrasystolic Beats in Hypertension and Heart Failure
2002 • 30 citations
Heart rate turbulence and left ventricular ejection fraction in Chagas disease
2005 • 29 citations
Intracellular control of calcium and potassium currents in cardiac cells.
1986 • 29 citations
Is postextrasystolic potentiation dependent on Starling's law? Biplane angiographic studies in normal subjects.
1980 • 28 citations
Influence of coronary artery bypass grafting on heart rate turbulence parameters
2004 • 27 citations
Heart rate turbulence parameters correlate with post–premature ventricular contraction changes in muscle sympathetic activity
2006 • 27 citations
Prognostic significance of heart rate turbulence in patients undergoing coronary artery bypass grafting
2003 • 26 citations
Ambulatory (Holter) Electrocardiography Technology
1992 • 26 citations
Relation between actual heart rate and autonomic effects of beta blockade in healthy men
2005 • 25 citations
Losartan Improves Heart Rate Variability and Heart Rate Turbulence in Heart Failure Due to Ischemic Cardiomyopathy
2007 • 25 citations
Influence of the point of origin on heart rate turbulence after stimulated ventricular and atrial premature beats
2004 • 25 citations
Differences in heart rate turbulence between patients with coronary artery disease and patients with ventricular arrhythmias but structurally normal hearts
2004 • 25 citations
The Analysis of Variability
1994 • 24 citations
Postextrasystolic contractile decay always contains exponential and alternans components in canine heart
2000 • 21 citations
Role of hypotension in heart rate turbulence physiology
2005 • 20 citations
Heart rate turbulence and heart rate variability in patients with mitral valve prolapse
2006 • 19 citations
Influence of Basic Heart Rate and Sex on Heart Rate Turbulence in Healthy Subjects
2004 • 19 citations
Changes in Heart Rate, Heart Rate Variability, and Heart Rate Turbulence during Evolving Reperfused Myocardial Infarction
2005 • 18 citations
Heart Rate Turbulence as a Noninvasive Risk Predictor of Ventricular Tachyarrhythmias in Myotonic Dystrophy Type 1
2006 • 17 citations
Circadian changes in heart rate turbulence parameters
2004 • 17 citations
Heart Rate Variability Assessment in Patients with Mitral Valve Prolapse Syndrome
1993 • 16 citations
Baseline arterial pressure affects sympathoexcitatory responses to ventricular premature beats
1995 • 16 citations
Heart Rate Turbulence Slope Reduction in Imminent Ventricular Tachyarrhythmia and its Implications
2006 • 15 citations
Demonstration of circadian rhythm in heart rate turbulence using novel application of correlator functions
2006 • 15 citations
Turbulence Slope After Atrial Premature Complexes Is an Independent Predictor of Mortality in Survivors of Acute Myocardial Infarction
2004 • 14 citations
Effects of Atropine and Pirenzepine on Heart Rate Turbulence
2006 • 13 citations
Similarity of spontaneous and induced heart rate and blood pressure turbulence.
2003 • 13 citations
Cardiac Autonomic Function Evaluated by the Heart Rate Turbulence Method was not Changed in Obese Patients without Co-morbidities
2007 • 12 citations
Altered Autonomic Cardiac Control Predicts Restenosis After Percutaneous Coronary Intervention
2006 • 12 citations
Sinus node sequences after atrial stimulation: similarities of effects of different methods.
1985 • 11 citations
Heart Rate Turbulence in Children—Age and Heart Rate Relationships
2007 • 10 citations
Effect of electrophysiologic character of ventricular premature beat on heart rate turbulence
2004 • 10 citations
A new sign of sympathetic neurocirculatory failure: premature ventricular contraction as a “one-beat Valsalva maneuver”
2000 • 9 citations
Prognostic value of hart rate turbulence and heart rate variability in children with dilated cardiomyopathy
2007 • 9 citations
Holter analyses in children with adenotonsillar hypertrophy
2006 • 9 citations
Correlation of Heart Rate Turbulence with Sympathovagal Balance in Patients with Acute Myocardial Infarction
2005 • 9 citations
Ventriculophasic Sinus Arrhythmia in the Presence of Artificial Pacemaker Induced Ventricular Rhythm
1970 • 9 citations
Interventions changing heart rate variability after acute myocardial infarction
1995 • 8 citations
[Ventricular premature systoles causing ventriculophasic sinus arrhythmia (author's transl)].
1979 • 8 citations
Relation between sinus rates preceding and following ectopic beats occurring in isolation and as episodes of bigeminy in young healthy subjects
2002 • 8 citations
Human autonomic rhythms : vagal-cardiac mechanisms in tetraplegic patients
1994 • 7 citations
The Instantaneous Effect of Aortic Pressure on Atrial Rate in Complete Atrioventricular Block
1967 • 7 citations
EFFECT OF BENAZEPRIL ON HEART RATE TURBULENCE IN PATIENTS WITH DILATED CARDIOMYOPATHY
2007 • 7 citations
Carvedilol Versus Metoprolol in the Acute Phase of Myocardial Infarction:
2005 • 6 citations
Heart rate variability in patients with stable angina pectoris
2009 • 6 citations
Heart Rate Turbulence after Ventricular Pacing Trains During Programmed Ventricular Stimulation
2007 • 4 citations
11)冠動脈バイパス術後早期に左内胸動脈体部に高度狭窄が生じた症例(日本循環器学会 第182回関東甲信越地方会)
2002 • 3 citations
Heart rate turbulence: an additional parameter in determining the need for mechanical relief of mitral stenosis?
2007 • 3 citations
Refined risk stratification by heart rate turbulence in patients with reduced left ventricular function early after myocardial infarction: Results of the DINAMIT Holter substudy
2005 • 3 citations
Heart Rate Turbulence After Short Runs of Nonsustained Ventricular Tachycardia in Chronic Heart Failure
2007 • 2 citations
814 Influence of sinus node dysfunction, diabetes mellitus and surgical heart denervation on heart rate turbulence
2005 • 1 citations
120 Heart rate turbulence slope triggered by atrial premature complexes correlates with phenylephrine baroreflex sensitivity in the ATRAMI study
2005 • 1 citations
Deleted Work
1955 • 0 citations