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Heart Rate Turbulence: Standards of Measurement, Physiological Interpretation, and Clinical Use

Data up to Jan 2025

Published2008
Citations443
References274

Total Citations Per Year

Abstract

References (274)

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1992 • 238 citations

Heart rate turbulence-based predictors of fatal and nonfatal cardiac arrest (The autonomic tone and reflexes after myocardial infarction substudy)

2002 • 236 citations

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Time course of recovery of heart period variability after myocardial infarction

1991 • 228 citations

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1989 • 225 citations

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1975 • 220 citations

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1973 • 220 citations

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1991 • 216 citations

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1989 • 215 citations

Reproducibility and relation to mean heart rate of heart rate variability in normal subjects and in patients with congestive heart failure secondary to coronary artery disease

1991 • 207 citations

Spinal sympathetic reflexes initiated by coronary receptors

1971 • 205 citations

Relaxation of the ACh-induced potassium current in the rabbit sinoatrial node cell

1978 • 200 citations

Effects of beta blockers (atenolol or metoprolol) on heart rate variability after acute myocardial infarction

1994 • 199 citations

Complex heart rate variability and serum norepinephrine levels in patients with advanced heart failure

1994 • 197 citations

Decreased cardiac parasympathetic activity in chronic heart failure and its relation to left ventricular function.

1992 • 194 citations

Reduced sinus arrhythmia in diabetic autonomic neuropathy: diagnostic value of an age-related normal range.

1982 • 191 citations

Circadian rhythm of heart rate variability after acute myocardial infarction and its influence on the prognostic value of heart rate variability

1990 • 187 citations

Single cardiac vagal fiber activity, acute myocardial ischemia, and risk for sudden death.

1991 • 187 citations

Power Spectral Analysis of Heart-Rate Variations Improves Assessment of Diabetic Cardiac Autonomic Neuropathy

1992 • 186 citations

Heart rate variability from 24-hour electrocardiography and the 2-year risk for sudden death.

1993 • 185 citations

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2001 • 182 citations

Circadian rhythm of heart rate variability in survivors of cardiac arrest

1992 • 179 citations

Muscarinic control of the hyperpolarization‐activated current (if) in rabbit sino‐atrial node myocytes.

1988 • 178 citations

Spectral Analysis of Heart Rate in Diabetic Autonomic Neuropathy

1991 • 174 citations

Sympathetic nervous system and cardiac arrhythmias

1990 • 170 citations

Reduced parasympathetic cardiac control in patients with hypertension at rest and under mental stress

1994 • 170 citations

Stability over time of heart period variability in patients with previous myocardial infarction and ventricular arrhythmias

1992 • 147 citations

Reflex versus tonic vagal activity as a prognostic parameter in patients with sustained ventricular tachycardia or ventricular fibrillation.

1994 • 147 citations

Efficient estimation of the heart period power spectrum suitable for physiologic or pharmacologic studies

1990 • 146 citations

Relation of heart rate and blood pressure turbulence following premature ventricular complexes to baroreflex sensitivity in chronic congestive heart failure

2001 • 143 citations

Mechanisms controlling cardiac autonomic function and their relation to arrhythmogenesis

1986 • 142 citations

Heart rate variability in patients with ventricular arrhythmias: Effect of antiarrhythmic drugs

1991 • 141 citations

Prognostic value and physiological correlates of heart rate variability in chronic severe mitral regurgitation.

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Circadian variation of spectral indices of heart rate variability after myocardial infarction

1992 • 132 citations

Positive Chronotropic Effect of Increasing Right Atrial Pressure in the Isolated Mammalian Heart

1956 • 128 citations

Altered pattern of circadian neural control of heart period in mild hypertension

1991 • 126 citations

Clinical Guide to Cardiac Autonomic Tests

1998 • 120 citations

Assessment of heart rate variability in hypertrophic cardiomyopathy. Association with clinical and prognostic features.

1993 • 117 citations

Dynamic Electrocardiography

2004 • 116 citations

Comparison of heart rate variability in survivors and nonsurvivors of sudden cardiac arrest

1992 • 114 citations

Blunted arterial baroreflex causes “pathological” heart rate turbulence

2000 • 112 citations

Heart rate variability for risk stratification of life-threatening arrhythmias

1993 • 111 citations

Heart rate turbulence predicts all-cause mortality and sudden death in congestive heart failure patients

2008 • 109 citations

Assessment of autonomic response by broad-band respiration

1989 • 108 citations

Tight Mechanism Correlation Between Heart Rate Turbulence and Baroreflex Sensitivity: Sequential Autonomic Blockade Analysis

2002 • 108 citations

Evaluation of Heart-Rate Turbulence as a New Prognostic Marker in Patients With Chronic Heart Failure.

2002 • 105 citations

Effects of Ventricular Premature Stimulus Coupling Interval on Blood Pressure and Heart Rate Turbulence

2002 • 105 citations

Low doses of scopolamine increase cardiac vagal tone in the acute phase of myocardial infarction.

1993 • 104 citations

Autonomic Nervous System Adaptations to Short-term Exercise Training

1992 • 100 citations

Scopolamine increases vagal tone and vagal reflexes in patients after myocardial infarction

1993 • 100 citations

Power spectral analysis of heart rate variability in traumatic quadriplegic humans

1990 • 99 citations

Enhancement of sympathetic nerve activity by single premature ventricular beats in humans

1989 • 98 citations

Spectral analysis of heart rate variability following human heart transplantation: evidence for functional reinnervation

1988 • 96 citations

Scopolamine improves autonomic balance in advanced congestive heart failure.

1994 • 94 citations

Spectral analysis of heart rate variability signal and respiration in diabetic subjects

1990 • 91 citations

Responses of the Sino-atrial Node to Change in Pressure in the Sinus Node Artery

1967 • 89 citations

Prognostic value of heart rate variability after myocardial infarction. A comparison of different data-processing methods

1989 • 89 citations

Assessment of autonomic regulation of heart rate variability by the method of complex demodulation

1989 • 88 citations

Heart rate turbulence

2003 • 87 citations

Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction

2005 • 85 citations

Do Increases in Markers of Vagal Activity Imply Protection From Sudden Death?

1995 • 85 citations

Effects of metoprolol on heart rate variability in survivors of acute myocardial infarction

1993 • 84 citations

Heart rate turbulence: A 5-year review

2004 • 84 citations

Time-domain system for assessing variation in heart rate

1988 • 84 citations

Prognostic Significance of Heart Rate Turbulence Following Ventricular Premature Beats in Patients with Idiopathic Dilated Cardiomyopathy

2003 • 84 citations

Heart Rate Variability and Heart Rate Turbulence in Patients With Type 2 Diabetes Mellitus With Versus Without Cardiac Autonomic Neuropathy

2007 • 82 citations

Temporal changes and prognostic significance of measures of heart rate dynamics after acute myocardial infarction in the beta-blocking era

2003 • 81 citations

Conventional heart rate variability analysis of ambulatory electrocardiographiic recording fails to predict imminent ventricular fibrillation

1993 • 79 citations

On the kinetics of the potassium channel activated by acetylcholine in the S-A node of the rabbit heart

1980 • 79 citations

Effect of stretch on the isolated cat sinoatrial node

1966 • 79 citations

Effects of localized stretch of the sinoatrial node region of the dog heart

1966 • 78 citations

Influences of neural mechanisms on heart period and arterial pressure variabilities in quadriplegic patients

1994 • 78 citations

Effect of atropine on heart rate turbulence

2002 • 73 citations

Influence of the recognition artefact in automatic analysis of long-term electrocardiograms on time-domain measurement of heart rate variability

1993 • 66 citations

ANGINA PECTORIS FOLLOWING A CRUSHING ACCIDENT

1939 • 66 citations

Relationships between beat-to-beat interval and the strength of contraction in the healthy and diseased human heart.

1984 • 64 citations

A phenomenon of heart-rate turbulence, its evaluation, and prognostic value.

2002 • 63 citations

Effects of low dose transdermal scopolamine on heart rate variability in acute myocardial infarction

1993 • 62 citations

Heart-rate spectral analysis: A noninvasive probe of cardiovascular regulation in critically ill children with heart disease

1988 • 62 citations

Risk Stratification Using Heart Rate Turbulence and Ventricular Arrhythmia in MADIT II: Usefulness and Limitations of a 10‐Minute Holter Recording

2004 • 58 citations

Heart rate turbulence and death due to cardiac decompensation in patients with chronic heart failure

2006 • 57 citations

Influence of transdermal scopolamine on cardiac sympathovagal interaction after acute myocardial infarction

1993 • 57 citations

A reflex increase in heart rate from distension of the junction between the superior vena cava and the right atrium

1972 • 56 citations

Sympathetic neural modulation of cardiac impulse initiation and repolarization in the newborn rat.

1990 • 55 citations

FURTHER STUDIES ON THE PHYSIOLOGY OF HEART-BLOCK IN MAMMALS

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QRS duration and late mortality in unselected post-infarction patients of the revascularization era

2005 • 54 citations

Postextrasystolic regulation patterns of blood pressure and heart rate in patients with idiopathic dilated cardiomyopathy

2002 • 54 citations

The accuracy of power-spectrum analysis of heart-rate variability from annotated RR lists generated by Holter systems

1994 • 54 citations

Unexpected interaction between beta-adrenergic blockade and heart rate variability before and after myocardial infarction. A longitudinal study in dogs at high and low risk for sudden death.

1994 • 54 citations

Significance of long term components of heart rate variability for the further prognosis after acute myocardial infarction

1990 • 53 citations

Impaired cardiac autonomic nervous activity predicts sudden cardiac death in patients with operated and unoperated congenital cardiac disease

2006 • 52 citations

Reflex Cardiac Activity in Ischemia and Reperfusion

2003 • 50 citations

Heart Rate Turbulence, Depression, and Survival After Acute Myocardial Infarction

2006 • 50 citations

Beta-blocking effect of propafenone based on spectral analysis of heart rate variability

1992 • 49 citations

Regular physical exercise, heart rate variability and turbulence in a 6-year randomized controlled trial in middle-aged men: The DNASCO study

2005 • 48 citations

Relationship Between Heart Rate Turbulence and Heart Rate, Heart Rate Variability, and Number of Ventricular Premature Beats in Coronary Patients

2004 • 48 citations

Hemodynamics and Autonomic Control of Heart Rate Turbulence

2005 • 46 citations

Increased myocardial vulnerability and autonomic nervous system imbalance in obstructive sleep apnea syndrome

2006 • 46 citations

Diurnal variations of neurocardiac rhythms in acute myocardial infarction

1991 • 45 citations

Physiology of the Cardiac Autonomic System

1998 • 45 citations

Relation of Heart Rate Turbulence to Severity of Heart Failure

2006 • 45 citations

Cardiac vagal activity, myocardial ischemia and sudden death

1995 • 45 citations

Responses of sympathetic nerves to programmed ventricular stimulation

1987 • 44 citations

The effect on heart rate of distending the atrial appendages in the dog

1972 • 44 citations

Mechanisms involved in heart rate turbulence.

2002 • 44 citations

Predicting mortality after myocardial infarction from the response of RR variability to antiarrhythmic drug therapy

1994 • 43 citations

Heart Rate Turbulence following Ventricular Premature Beats in Healthy Controls

2003 • 43 citations

The 24-hour heart rate behavior in long-term survivors of cardiac transplantation

1988 • 43 citations

HEART-BLOCK

1918 • 42 citations

Heart rate turbulence after atrial premature beats before spontaneous onset of atrial fibrillation

2005 • 42 citations

Heart block

1944 • 42 citations

Abnormal Heart Rate Turbulence Predicts the Initiation of Ventricular Arrhythmias

2005 • 41 citations

Heart Rate Turbulence and Clinical Prognosis in Hypertrophic Cardiomyopathy and Myocardial Infarction

2003 • 41 citations

Heart rate variability and turbulence in hyperthyroidism before, during, and after treatment

2004 • 40 citations

Heart Rate Turbulence after Ventricular and Atrial Premature Beats in Subjects without Structural Heart Disease

2003 • 39 citations

The mechanism of irregular sinus rhythm in auriculoventricular heart block

1948 • 38 citations

Turbulence dynamics: An independent predictor of late mortality after acute myocardial infarction

2005 • 38 citations

Effects of Changes in Intraluminal Pressure on Inotropic and Chronotropic Responses of Isolated Mammalian Hearts

1958 • 37 citations

Effect of quinapril on blood pressure and heart rate in congestive heart failure

1992 • 37 citations

Characteristics of heart beat intervals and prediction of death

2004 • 36 citations

Influence of obstructive sleep apnea on heart rate turbulence

2005 • 36 citations

Assessment of Heart Rate Turbulence in the Acute Phase of Myocardial Infarction for Long‐Term Prognosis

2003 • 36 citations

Restoration of Heart Rate Turbulence by Titrated Beta‐Blocker Therapy in Patients with Advanced Congestive Heart Failure:

2004 • 34 citations

Changes in Autonomic Tone Following Thrombolytic Therapy for Acute Myocardial Infarction:

1994 • 34 citations

Heart Rate Turbulence in Chagas Disease

2003 • 32 citations

Induction of heart rate and blood pressure turbulence in the electrophysiologic laboratory

2002 • 31 citations

Association of the Heart Rate Turbulence with Classic Risk Stratification Parameters in Postmyocardial Infarction Patients

2003 • 31 citations

Premature ventricular contractions and reflex sympathetic activation in cats

1989 • 30 citations

Impact of Age and Basic Heart Rate on Heart Rate Turbulence in Healthy Persons

2005 • 30 citations

Heart rate turbulence and other autonomic risk markers for arrhythmia risk stratification in dilated cardiomyopathy

2008 • 30 citations

Heart Rate Turbulence After Atrial and Ventricular Premature Beats: Relation to Left Ventricular Function and Coupling Intervals

2003 • 30 citations

Sympathetic Response to Ventricular Extrasystolic Beats in Hypertension and Heart Failure

2002 • 30 citations

Heart rate turbulence and left ventricular ejection fraction in Chagas disease

2005 • 29 citations

Intracellular control of calcium and potassium currents in cardiac cells.

1986 • 29 citations

Is postextrasystolic potentiation dependent on Starling's law? Biplane angiographic studies in normal subjects.

1980 • 28 citations

Influence of coronary artery bypass grafting on heart rate turbulence parameters

2004 • 27 citations

Heart rate turbulence parameters correlate with post–premature ventricular contraction changes in muscle sympathetic activity

2006 • 27 citations

Prognostic significance of heart rate turbulence in patients undergoing coronary artery bypass grafting

2003 • 26 citations

Ambulatory (Holter) Electrocardiography Technology

1992 • 26 citations

Relation between actual heart rate and autonomic effects of beta blockade in healthy men

2005 • 25 citations

Losartan Improves Heart Rate Variability and Heart Rate Turbulence in Heart Failure Due to Ischemic Cardiomyopathy

2007 • 25 citations

Influence of the point of origin on heart rate turbulence after stimulated ventricular and atrial premature beats

2004 • 25 citations

Differences in heart rate turbulence between patients with coronary artery disease and patients with ventricular arrhythmias but structurally normal hearts

2004 • 25 citations

The Analysis of Variability

1994 • 24 citations

Postextrasystolic contractile decay always contains exponential and alternans components in canine heart

2000 • 21 citations

Role of hypotension in heart rate turbulence physiology

2005 • 20 citations

Heart rate turbulence and heart rate variability in patients with mitral valve prolapse

2006 • 19 citations

Influence of Basic Heart Rate and Sex on Heart Rate Turbulence in Healthy Subjects

2004 • 19 citations

Changes in Heart Rate, Heart Rate Variability, and Heart Rate Turbulence during Evolving Reperfused Myocardial Infarction

2005 • 18 citations

Heart Rate Turbulence as a Noninvasive Risk Predictor of Ventricular Tachyarrhythmias in Myotonic Dystrophy Type 1

2006 • 17 citations

Circadian changes in heart rate turbulence parameters

2004 • 17 citations

Heart Rate Variability Assessment in Patients with Mitral Valve Prolapse Syndrome

1993 • 16 citations

Baseline arterial pressure affects sympathoexcitatory responses to ventricular premature beats

1995 • 16 citations

Heart Rate Turbulence Slope Reduction in Imminent Ventricular Tachyarrhythmia and its Implications

2006 • 15 citations

Demonstration of circadian rhythm in heart rate turbulence using novel application of correlator functions

2006 • 15 citations

Turbulence Slope After Atrial Premature Complexes Is an Independent Predictor of Mortality in Survivors of Acute Myocardial Infarction

2004 • 14 citations

Effects of Atropine and Pirenzepine on Heart Rate Turbulence

2006 • 13 citations

Similarity of spontaneous and induced heart rate and blood pressure turbulence.

2003 • 13 citations

Cardiac Autonomic Function Evaluated by the Heart Rate Turbulence Method was not Changed in Obese Patients without Co-morbidities

2007 • 12 citations

Altered Autonomic Cardiac Control Predicts Restenosis After Percutaneous Coronary Intervention

2006 • 12 citations

Sinus node sequences after atrial stimulation: similarities of effects of different methods.

1985 • 11 citations

Heart Rate Turbulence in Children—Age and Heart Rate Relationships

2007 • 10 citations

Effect of electrophysiologic character of ventricular premature beat on heart rate turbulence

2004 • 10 citations

A new sign of sympathetic neurocirculatory failure: premature ventricular contraction as a “one-beat Valsalva maneuver”

2000 • 9 citations

Prognostic value of hart rate turbulence and heart rate variability in children with dilated cardiomyopathy

2007 • 9 citations

Holter analyses in children with adenotonsillar hypertrophy

2006 • 9 citations

Correlation of Heart Rate Turbulence with Sympathovagal Balance in Patients with Acute Myocardial Infarction

2005 • 9 citations

Ventriculophasic Sinus Arrhythmia in the Presence of Artificial Pacemaker Induced Ventricular Rhythm

1970 • 9 citations

Interventions changing heart rate variability after acute myocardial infarction

1995 • 8 citations

[Ventricular premature systoles causing ventriculophasic sinus arrhythmia (author's transl)].

1979 • 8 citations

Relation between sinus rates preceding and following ectopic beats occurring in isolation and as episodes of bigeminy in young healthy subjects

2002 • 8 citations

Human autonomic rhythms : vagal-cardiac mechanisms in tetraplegic patients

1994 • 7 citations

The Instantaneous Effect of Aortic Pressure on Atrial Rate in Complete Atrioventricular Block

1967 • 7 citations

EFFECT OF BENAZEPRIL ON HEART RATE TURBULENCE IN PATIENTS WITH DILATED CARDIOMYOPATHY

2007 • 7 citations

Carvedilol Versus Metoprolol in the Acute Phase of Myocardial Infarction:

2005 • 6 citations

Heart rate variability in patients with stable angina pectoris

2009 • 6 citations

Heart Rate Turbulence after Ventricular Pacing Trains During Programmed Ventricular Stimulation

2007 • 4 citations

11)冠動脈バイパス術後早期に左内胸動脈体部に高度狭窄が生じた症例(日本循環器学会 第182回関東甲信越地方会)

2002 • 3 citations

Heart rate turbulence: an additional parameter in determining the need for mechanical relief of mitral stenosis?

2007 • 3 citations

Refined risk stratification by heart rate turbulence in patients with reduced left ventricular function early after myocardial infarction: Results of the DINAMIT Holter substudy

2005 • 3 citations

Heart Rate Turbulence After Short Runs of Nonsustained Ventricular Tachycardia in Chronic Heart Failure

2007 • 2 citations

814 Influence of sinus node dysfunction, diabetes mellitus and surgical heart denervation on heart rate turbulence

2005 • 1 citations

120 Heart rate turbulence slope triggered by atrial premature complexes correlates with phenylephrine baroreflex sensitivity in the ATRAMI study

2005 • 1 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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Heart Rate Turbulence: Standards of Measurement, Physiological Interpretation, and… (2008) – Journal of the American College of Cardiology | Metascience Observatory Explorer