Absorption of angiotensin II antagonists in Ussing chambers, Caco-2, perfused jejunum loop and in vivo:

Active Transport of Sodium as the Source of Electric Current in the Short‐circuited Isolated Frog Skin.

1951 • 2,379 citations

Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1

2001 • 1,479 citations

In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man--fact or myth.

1997 • 980 citations

A Human Colonic Cell Line Sharing Similarities With Enterocytes as a Model to Examine Oral Absorption: Advantages and Limitations of the Caco-2 Model

1997 • 433 citations

Ionic Conductances of Extracellular Shunt Pathway in Rabbit Ileum

1972 • 416 citations

Correlation of Drug Absorption with Molecular Surface Properties

1996 • 408 citations

Caco-2 monolayers in experimental and theoretical predictions of drug transport

1996 • 268 citations

Quantitative Approaches To Delineate Paracellular Diffusion in Cultured Epithelial Cell Monolayers

1994 • 261 citations

The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability.

1992 • 201 citations

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans.

1995 • 190 citations

In vitro systems for studying intestinal drug absorption

1995 • 178 citations

Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway.

1997 • 166 citations

Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

1997 • 166 citations

Convective solvent flow across the skin during iontophoresis.

1993 • 162 citations

Flux Measurements across Caco-2 Monolayers May Predict Transport in Human Large Intestinal Tissue

1996 • 154 citations

The use of the intestinal epithelial cell culture model, Caco-2, in pharmaceutical development

1996 • 138 citations

A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa.

1993 • 92 citations

Characterisation of a newly isolated Caco-2 clone (TC-7), as a model of transport processes and biotransformation of drugs

1995 • 80 citations

In Vitro Absorption Studies and Their Relevance to Absorption from the GI Tract

1997 • 76 citations

Desolvation energy: a major determinant of absorption, but not clearance, of peptides in rats.

1991 • 45 citations

Estimation of oral drug absorption in man based on intestine permeability in rats

1996 • 39 citations

Modulation of vascular calcium channel activity in response to acute volume expansion in rats

1995 • 11 citations

Studies on the mechanism of intestinal passage of the food comutagen harman, in the rabbit

1994 • 5 citations

Deleted Work

1955 • 0 citations