A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa.

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

1989 • 2,127 citations

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1991 • 1,787 citations

Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

1989 • 1,027 citations

Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells

1990 • 820 citations

Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa.

1990 • 565 citations

A comparison of numerical integrating algorithms by trapezoidal, Lagrange, and spline approximation

1978 • 423 citations

Penetration and enzymatic barriers to peptide and protein absorption

1989 • 402 citations

Transport and permeability properties of human Caco-2 cells: An in vitro model of the intestinal epithelial cell barrier

1990 • 234 citations

The influence of peptide structure on transport across Caco-2 cells.

1991 • 223 citations

Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption.

1993 • 207 citations

The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability.

1992 • 201 citations

(B) Mechanisms of peptide and protein absorption

1991 • 145 citations

Evidence for a Polarized Efflux System for Peptides in the Apical Membrane of Caco-2 Cells

1993 • 141 citations

The relationship between peptide structure and transport across epithelial cell monolayers

1992 • 117 citations

(B) Mechanisms of peptide and protein absorption

1991 • 94 citations

Desolvation energy: a major determinant of absorption, but not clearance, of peptides in rats.

1991 • 45 citations

Biophysical model approaches to mechanistic transepithelial studies of peptides

1990 • 41 citations

Nifedipine and verapamil block the memory-facilitating effect of corticotropin-releasing factor in rats

1991 • 35 citations

Mesenteric venous blood sampling in vivo in the rat.

1973 • 3 citations