Post-Translational Modifications of Eukaryotic Initiation Factor-5A (eIF-5a) as a New Target for Anti-Cancer Therapy

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Regulation of ferritin and transferrin receptor mRNAs.

1990 • 339 citations

Polyamines as biochemical markers of normal and malignant growth

1978 • 278 citations

Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor.

1981 • 267 citations

Hypusine: its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation.

1993 • 219 citations

Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D.

1983 • 205 citations

In vitro and in vivo effects of deferoxamine in neonatal acute leukemia

1987 • 185 citations

Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines

1993 • 178 citations

Is hypusine essential for eukaryotic cell proliferation?

1993 • 161 citations

The biosynthesis of protein-bound hypusine (N epsilon -(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon -(4-aminobutyl)lysine).

1982 • 154 citations

Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization.

1986 • 122 citations

Posttranslational formation of hypusine in a single major protein occurs generally in growing cells and is associated with activation of lymphocyte growth

1982 • 117 citations

Desferioxamine increases iron depletion and apoptosis induced by ara‐C of human myeloid leukaemic cells

1998 • 116 citations

Polyamines alter sequence-specific DNA-protein interactions

1995 • 106 citations

Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD.

1990 • 99 citations

Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine

1991 • 76 citations

Cytotoxic activities of a fusion protein comprised of TGFα and Pseudomonas exotoxin

1989 • 71 citations

Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40).

1991 • 66 citations

Cell-free synthesis of deoxyhypusine. Separation of protein substrate and enzyme and identification of 1,3-diaminopropane as a product of spermidine cleavage.

1988 • 55 citations

Upregulation of epidermal growth factor receptor induced by alpha-interferon in human epidermoid cancer cells.

1991 • 47 citations

Differences in the post‐translational modification of proteins by polyamines between weakly and highly metastatic B16 melanoma cells

1993 • 47 citations

Regulation of biosynthesis of hypusine in Chinese hamster ovary cells. Evidence for eIF-4D precursor polypeptides.

1987 • 47 citations

The active site of deoxyhypusyl hydroxylase: use of catecholpeptides and their component chelator and peptide moieties as molecular probes

1991 • 43 citations

The mammalian hypusine-containing protein, eukaryotic initiation factor 4D. Structural homology of this protein from several species.

1984 • 43 citations

Interferon α2 recombinant and epidermal growth factor modulate proliferation and hypusine synthesis in human epidermoid cancer KB cells

1997 • 43 citations

Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation

1998 • 41 citations

EGF Stimulates Polyamine Uptake in Caco-2 Cells

1995 • 38 citations

Identification of a substrate site for transglutaminases on the human protein synthesis initiation factor 5A

1995 • 36 citations

A new compound which reversibly arrests T lymphocyte cell cycle near the G1S boundary

1990 • 36 citations

α‐interferon potentiates epidermal growth factor receptor‐mediated effects on human epidermoid carcinoma KB cells

1995 • 35 citations

Inhibition of deoxyhypusine hydroxylase by polyamines and by a deoxyhypusine peptide

1989 • 23 citations

Cytosine arabinoside increases the binding of125I-labelled epidermal growth factor and125I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor) mAb

1993 • 22 citations

Tissue transglutaminase expression affects hypusine metabolism in BALB/c 3T3 cells

1998 • 21 citations

Pharmacological modulation of peptide growth factor receptor expression on tumor cells as a basis for cancer therapy

1994 • 20 citations

Developmental Pattern for Deoxyhypusine Hydroxylase in Rat Brain

1988 • 19 citations

High-performance liquid chromatographic method for determination of hypusine and deoxyhypusine

1990 • 15 citations

Inhibition of acid secretory response and induction of ornithine decarboxylase and its mRNA by TGFα and EGF in isolated rat gastric glands

1995 • 11 citations

α-Interferon Induces Depletion of Intracellular Iron Content and Up Regulation of Functional Transferrin Receptors on Human Epidermoid Cancer kb Cells

1994 • 9 citations

Transient exposure to cytarabine increases peptide growth factor receptor expression and tumorigenicity of melanoma cells.

1997 • 6 citations

Structural organization of the human eukaryotic initiation factor 5A precursor and its site-directed variant Lys50 ? Arg

1999 • 3 citations

Deleted Work

1955 • 0 citations