Design of Chemically Modified and Recombinant Hemoglobins as Potential Red Cell Substitutes

X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human Deoxyhaemoglobin

1972 • 731 citations

Generation of β-globin by sequence-specific proteolysis of a hybrid protein produced in Escherichia coli

1984 • 374 citations

Oxygen Affinity of Hemoglobin and Red Cell Acid Base Status

1974 • 368 citations

Isolation and characterization of a new hemoglobin derivative cross-linked between the alpha chains (lysine 99 alpha 1----lysine 99 alpha 2).

1986 • 296 citations

Affinity labeling of the polyphosphate binding site of hemoglobin

1972 • 287 citations

Production of unmodified human adult hemoglobin in Escherichia coli.

1993 • 142 citations

The Chloride Effect in Human Haemoglobin

1994 • 130 citations

New effectors of human hemoglobin: structure and function

1990 • 129 citations

Hemoglobin-based red cell substitutes

1991 • 128 citations

Hemoglobin-based Red Cell Substitutes

1993 • 128 citations

Synthesis of Wild Type and Mutant Human Hemoglobins in Saccharomyces cerevisiae

1991 • 120 citations

Hemoglobin providence. Functional consequences of two alterations of the 2,3-diphosphoglycerate binding site at position beta 82.

1976 • 119 citations

Hemoglobin covalently bridged across the polyphosphate binding site

1975 • 117 citations

Soluble dextran-hemoglobin complex as a potential blood substitute.

1976 • 117 citations

Allosteric modifiers of hemoglobin: 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid derivatives that lower the oxygen affinity of hemoglobin in red cell suspensions, in whole blood, and in vivo in rats

1992 • 106 citations

Nuclear magnetic resonance quadrupole relaxation studies of chloride binding to human oxy- and deoxyhaemoglobin

1972 • 104 citations

Equilibrium Oxygen Binding to Human Hemoglobin Cross-linked Between the α Chains by Bis(3,5-dibromosalicyl) Fumarate

1989 • 92 citations

Labeling of hemoglobin with pyridoxal phosphate.

1982 • 73 citations

Oxygen-linked binding sites for inorganic anions to hemoglobin.

1980 • 70 citations

[13] Preparation and properties of hemoglobin modified with derivatives of pyridoxal

1981 • 63 citations

Bis-pyridoxal polyphosphates: A new class of specific intramolecular crosslinking agents for hemoglobin

1988 • 49 citations

Recombinant human sickle hemoglobin expressed in yeast.

1993 • 47 citations

Selective carboxymethylation of the alpha-amino groups of hemoglobin. Effect on functional properties.

1983 • 43 citations

Three-point crosslinking: potential red cell substitutes from the reaction of trimesoyl tris(methyl phosphate) with hemoglobin

1992 • 42 citations

Pseudo Cross-link of Human Hemoglobin with Mono- (3,5-dibromosalicyl)fumarate

1989 • 37 citations

The functional, oxygen-linked chloride binding sites of hemoglobin are contiguous within a channel in the central cavity

1992 • 35 citations

Biochemical and functional properties of recombinant human sickle hemoglobin expressed in yeast.

1993 • 34 citations

Specifically carboxymethylated hemoglobin as an analogue of carbamino hemoglobin. Solution and X-ray studies of carboxymethylated hemoglobin and X-ray studies of carbamino hemoglobin.

1987 • 30 citations

The intravascular persistence of crosslinked human hemoglobin.

1989 • 28 citations

Blood exchange with pyridoxalated and polymerized hemoglobin solution.

1982 • 24 citations

Properties of carboxymethylated crosslinked hemoglobin A

1987 • 24 citations

Influence of ligation state and concentration of hemoglobin A on its crosslinking by glycolaldehyde: functional properties of crosslinked, carboxymethylated hemoglobin

1988 • 21 citations

Enhanced oxygen unloading by an interdimerically crosslinked hemoglobin in an isolated perfused rabbit heart.

1984 • 21 citations

Random chemical modification of the oxygen-linked chloride-binding sites of hemoglobin: Those in the central dyad axis may influence the transition between deoxy- and oxy-hemoglobin

1993 • 20 citations

High-level production of human α- and β-globins in insect cells

1992 • 7 citations