The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain.

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Protein Inhibitors of Proteinases

1980 • 2,220 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes

1980 • 947 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

Human α1-proteinase inhibitor

1984 • 773 citations

The Origin and Evolution of Retroposons

1985 • 555 citations

Mutation of Antitrypsin to Antithrombin

1983 • 430 citations

A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha1-proteinase inhibitor

1980 • 410 citations

Crystal structure of ovalbumin as a model for the reactive centre of serpins

1990 • 394 citations

Improved estimation of DNA fragment lengths from agarose gels

1981 • 304 citations

Accelerated evolution in the reactive centre regions of serine protease inhibitors

1987 • 293 citations

Evolution of Class-I MHC Genes and Proteins: From Natural Selection to Thymic Selection

1990 • 286 citations

The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens.

1983 • 280 citations

X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor.

1986 • 272 citations

Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.

1987 • 267 citations

Cloning and sequence analysis of cDNA for rat angiotensinogen.

1983 • 237 citations

THE EVOLUTION OF MULTIGENE FAMILIES: Human Haptoglobin Genes

1986 • 235 citations

Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases.

1986 • 177 citations

Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus.

1987 • 171 citations

The Serpins: Evolution and Adaptation in a Family of Protease Inhibitors

1987 • 169 citations

Evolution of immunoglobulin V genes: Evidence indicating that recently duplicated human Vκ sequences have diverged by gene conversion

1983 • 165 citations

Crystal structure of plakalbumin, a proteolytically nicked form of ovalbumin

1990 • 164 citations

Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily.

1987 • 161 citations

Refined 1.2 A crystal structure of the complex formed between subtilisin Carlsberg and the inhibitor eglin c. Molecular structure of eglin and its detailed interaction with subtilisin.

1986 • 147 citations

Most highly repeated dispersed DNA families in the mouse genome.

1984 • 136 citations

Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions

1984 • 135 citations

Tissue kallikrein-binding protein is a serpin. I. Purification, characterization, and distribution in normotensive and spontaneously hypertensive rats.

1990 • 133 citations

Synthesis in E. coli of α1-antitrypsin variants of therapeutic potential for emphysema and thrombosis

1985 • 125 citations

Functional evolutionary divergence of proteolytic enzymes and their inhibitors

1989 • 89 citations

Mouse plasma trypsin inhibitors. Isolation and characterization of alpha-1-antitrypsin and contrapsin, a novel trypsin inhibitor.

1982 • 76 citations

Altered specificities of genetically engineered α₁ antitrypsin variants

1986 • 69 citations

A Genetic Locus Closely Linked to a Protease Inhibitor Gene Complex Controls the Level of Multiple RNA Transcripts

1985 • 62 citations

Type II hereditary angioneurotic edema that may result from a single nucleotide change in the codon for alanine-436 in the C1 inhibitor gene.

1990 • 60 citations

Characterization of recombinant human .alpha.2-antiplasmin and of mutants obtained by site-directed mutagenesis of the reactive site

1987 • 55 citations

Most Highly Repeated Dispersed DNA Families in the Mouse Genome

1984 • 50 citations

Site-directed mutagenesis of the reactive center (serine 394) of antithrombin III.

1988 • 50 citations

A family of cosmid vectors with the multi-copy R6K replication origin

1987 • 46 citations

Analysis of mouse major urinary protein genes: variation between the exonic sequences of group 1 genes and a comparison with an active gene out with group 1 both suggest that gene conversion has occurred between MUP genes.

1985 • 41 citations

Looking for relationships between the most repeated dispersed DNA sequences in the mouse: small R elements are found associated consistently with long MIF repeats.

1984 • 35 citations

The molecular pathology of the serpins.

1989 • 26 citations

CpG dinucleotides are "hotspots" for mutation in the antithrombin III gene. Twelve variants identified using the polymerase chain reaction.

1989 • 23 citations