Epidermal growth factor. Ability of tumor promoter to alter its degradation, receptor affinity and receptor number.

A graphic method for the determination and presentation of binding parameters in a complex system

1967 • 1,524 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes

1977 • 1,063 citations

Insulin interactions with its receptors: Experimental evidence for negative cooperativity

1973 • 717 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431.

1978 • 578 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

Characterization of the binding of 125-I-labeled epidermal growth factor to human fibroblasts

1975 • 432 citations

Human epidermal growth factor and the proliferation of human fibroblasts

1976 • 403 citations

Quantitative Aspects of the Insulin-Receptor Interaction in Liver Plasma Membranes

1974 • 378 citations

Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake.

1975 • 367 citations

Tumor-Promoting Phorbol Esters Inhibit Binding of Epidermal Growth Factor to Cellular Receptors

1978 • 355 citations

Epidermal Growth Factor: Receptors in Human Fibroblasts and Modulation of Action by Cholera Toxin

1973 • 328 citations

Epidermal growth factor. Relationship between receptor regulation and mitogenesis in 3T3 cells.

1978 • 324 citations

Characteristics of the Human Lymphocyte Insulin Receptor

1973 • 320 citations

Tumour promotor induces plasminogen activator

1976 • 316 citations

Two-stage chemical oncogenesis in cultures of C3H/10T1/2 cells.

1976 • 294 citations

Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell cultures

1976 • 250 citations

Radioimmunoassay of Epidermal Growth Factor

1972 • 226 citations

A developing factor in experimental blastogenesis

1944 • 221 citations

Stimulation of DNA synthesis by tumour promoter and pure mitogenic factors

1978 • 207 citations

Inhibition of epidermal growth factor binding to surface receptors by tumor promotors

1979 • 206 citations

Ultrastructural, histological, and biochemical alterations produced by 12-O-tetradecanoyl-phorbol-13-acetate on mouse epidermis and their relevance to skin tumor promotion.

1973 • 196 citations

Proliferation of corneal epithelium induced by epidermal growth factor

1973 • 196 citations

Cooperative properties of hormone receptors in cell membranes

1976 • 170 citations

Effect of a phorbol ester on a transformation-sensitive surface protein of chick fibroblasts

1976 • 159 citations

Transformation of C3H/10T1/2 CL8 mouse embryo fibroblasts by ultraviolet irradiation and a phorbol ester

1976 • 156 citations

Tumor-promoting activity of phorbol and four diesters of phorbol in mouse skin.

1971 • 155 citations

Effects of phorbol-12,13-diesters on prostaglandin production and phospholipase activity in canine kidney (MDCK) cells

1977 • 155 citations

Mechanism of tumor promoter inhibition of cellular binding of epidermal growth factor

1979 • 154 citations

Interaction of Epidermal Growth Factor (EGF) with Cultured Fibroblasts

1975 • 146 citations

Phorbol esters from croton oil chemical nature and biological activities

1967 • 135 citations

Epidermal growth factor stimulates prostaglandin biosynthesis by canine kidney (MDCK) cells

1977 • 133 citations

State of the viral DNA in rat cells transformed by polyoma virus. I. Virus rescue and the presence of nonintergrated viral DNA molecules

1976 • 127 citations

Membrane effects of tumor promoters: Stimulation of sugar uptake in mammalian cell cultures

1979 • 95 citations

Induction of cell division: Role of cell membrane sites

1972 • 90 citations

Calcium‐dependent stimulation of BALB/c 3T3 mouse cell DNA synthesis by a tumor‐promoting phorbol ester (PMA)

1976 • 88 citations

Ornithine decarboxylase induction and DNA synthesis in hamster embryo cell cultures treated with tumor-promoting phorbol diesters.

1977 • 88 citations

Phorbol esters as a tool in cell research?

1972 • 83 citations

Tumor promoters induce membrane changes detected by fluorescence polarization

1979 • 75 citations

The correlation of promotion of tumour growth and of induction of hyperplasia in epidermal two-stage carcinogenesis

1968 • 72 citations

Radioreceptor assay for epidermal growth factor

1979 • 56 citations

Effects of promoters on DNA synthesis in C3H/10T1/2 mouse fibroblasts.

1977 • 55 citations

Glucocorticoid‐mediated alteration in growth factor binding and action: Analysis of the binding change

1978 • 30 citations

Effects of the tumor promoter TPA on the induction of DNA synthesis in normal and RSV‐transformed rat fibroblasts

1979 • 8 citations