VACCINES AS TREATMENT STRATEGIES FOR RELAPSED PROSTATE CANCER

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer.

1994 • 534 citations

Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer.

1999 • 468 citations

Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.

1990 • 414 citations

Phase I clinical trial: T-cell therapy for prostate cancer using autologous dendritic cells pulsed with HLA-A0201-specific peptides from prostate-specific membrane antigen

1996 • 398 citations

CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma

1998 • 375 citations

Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo

1994 • 300 citations

Selection of tumor antigens as targets for immune attack using immunohistochemistry: II. Blood group-related antigens

1997 • 292 citations

Selection of tumor antigens as targets for immune attack using immunohistochemistry: I. Focus on gangliosides

1997 • 279 citations

Carbohydrate vaccines in cancer: Immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man

1999 • 253 citations

Generation of monoclonal antibodies reacting with normal and cancer cells of human breast.

1983 • 230 citations

Demonstration of a Rational Strategy for Human Prostate Cancer Gene Therapy

1994 • 210 citations

GM2-KLH conjugate vaccine: increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21.

1995 • 207 citations

Phase II prostate cancer vaccine trial: Report of a study involving 37 patients with disease recurrence following primary treatment

1999 • 191 citations

Expression of potential target antigens for immunotherapy on primary and metastatic prostate cancers.

1998 • 184 citations

Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes.

1994 • 184 citations

Immunotherapy of prostate cancer in the Dunning rat model: use of cytokine gene modified tumor vaccines.

1994 • 181 citations

GD3 vaccines for melanoma: superior immunogenicity of keyhole limpet hemocyanin conjugate vaccines.

1994 • 181 citations

Expression of Heterologous Sequences in Adenoviral Vectors

1992 • 171 citations

Induction of alpha-N-acetylgalactosamine-O-serine/threonine (Tn) antigen-mediated cellular immune response for active immunotherapy in mice.

1991 • 132 citations

Cellular Mucins: Targets for Immunotherapy

2017 • 130 citations

Presentation of prostate tumor antigens by dendritic cells stimulates T-cell proliferation and cytotoxicity

1996 • 120 citations

Gene Immunotherapy in Murine Acute Myeloid Leukemia: Granulocyte-Macrophage Colony-Stimulating Factor Tumor Cell Vaccines Elicit More Potent Antitumor Immunity Compared With B7 Family and Other Cytokine Vaccines

1998 • 118 citations

High efficiency gene transfer into primary human tumor explants without cell selection.

1993 • 116 citations

Intensified antitumor immunity by a cancer vaccine that produces granulocyte-macrophage colony-stimulating factor plus interleukin 4.

1996 • 112 citations

Immunochemical analysis of the determinant recognized by a monoclonal antibody (MBr1) which specifically binds to human mammary epithelial cells.

1983 • 103 citations

Cellular Mucins: Targets for Immunotherapy

1994 • 102 citations

Total Synthesis of a Human Breast Tumor Associated Antigen

1995 • 100 citations

Immune sera and monoclonal antibodies define two configurations for the sialyl Tn tumor antigen.

1995 • 95 citations

A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle

1999 • 88 citations

Immunization of Mice with a Fully Synthetic Globo H Antigen Results in Antibodies against Human Cancer Cells: A Combined Chemical—Immunological Approach to the Fashioning of an Anticancer Vaccine

1997 • 86 citations

Rapid transgene expression in lymphocyte and macrophage primary cultures after particle bombardment-mediated gene transfer

1993 • 84 citations

Immunologic approaches to the treatment of prostate cancer.

1999 • 83 citations

Application of the Glycal Assembly Method to the Concise Synthesis of Neoglycoconjugates of Ley and Leb Blood Group Determinants and of H-Type I and H-Type II Oligosaccharides

1995 • 71 citations

Gene Transfer into Mammalian Cells by Particle Bombardment

1994 • 52 citations

Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene

1990 • 41 citations

Analysis of human tumor associated Thomsen-Friedenreich antigen.

1990 • 39 citations

Regression of Established Mouse Leukemia by GM-CSF-Transduced Tumor Vaccine: Implications for Cytotoxic T Lymphocyte Responses and Tumor Burdens

1997 • 37 citations

Generation of allo-reactive cytotoxic T lymphocytes by particle bombardment-mediated gene transfer

1994 • 31 citations

Gene therapy: principles and potential.

1995 • 22 citations

Gene therapy for prostate cancer.

1996 • 20 citations

Targeted therapy for prostate cancer: the Memorial Sloan-Kettering Cancer Center approach.

1996 • 19 citations

Gene therapy for human prostate cancer. Translational research in the hormone refractory dunning prostate cancer model

1995 • 14 citations

Gene Therapy Approaches in Urologic Oncology

1995 • 10 citations

The Current Status of Gene Therapy for Prostate Cancer

1998 • 7 citations