St. John's wort flavonoids and their metabolites show antidepressant activity and accumulate in brain after multiple oral doses.

Pharmacokinetics and Bioavailability of Quercetin Glycosides in Humans

2001 • 593 citations

Depression in the community

1997 • 500 citations

Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers

2000 • 488 citations

Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin

2001 • 460 citations

Bioavailability of rutin and quercetin in rats

1997 • 435 citations

Flavonoids from Hypericum perforatum Show Antidepressant Activity in the Forced Swimming Test

2000 • 364 citations

Effects of Hypericum Extract (LI 160) in Biochemical Models of Antidepressant Activity

1997 • 281 citations

Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism

2003 • 266 citations

Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1.

1999 • 230 citations

St John's wort for depression

2005 • 219 citations

The Bioavailability of Quercetin in Pigs Depends on the Glycoside Moiety and on Dietary Factors

2003 • 148 citations

Pharmacokinetics and bioavailability of the flavonol quercetin in humans.

1999 • 140 citations

Identification of quercetin glucuronides in human plasma by high-performance liquid chromatography–tandem mass spectrometry

2001 • 138 citations

Hyperforin - Antidepressant Activity by a Novel Mechanism of Action

2001 • 128 citations

Hypericum Perforatum: A ???Modern??? Herbal Antidepressant

2006 • 123 citations

Inhibition of Synaptosomal Uptake of 3H-L-glutamate and 3H-GABA by Hyperforin, a Major Constituent of St. John's Wort The Role of Amiloride Sensitive Sodium Conductive Pathways

2000 • 118 citations

In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs

2002 • 110 citations

Activity Profiles of Two Hyperforin-Containing Hypericum Extracts in Behavioral Models

1998 • 97 citations

Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models

2003 • 96 citations

Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection

2006 • 85 citations

Validated method for the quantitation of quercetin from human plasma using high-performance liquid chromatography with electrochemical detection

1999 • 85 citations

Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex

1999 • 80 citations

Plasma Levels of Hypericin in Presence of Procyanidin B2 and Hyperoside: A Pharmacokinetic Study in Rats

2003 • 58 citations

In Vitro Binding Studies with Two Hypericum Perforatum Extracts - Hyperforin, Hypericin and Biapigenin - on 5-HT6, 5-HT7, GABAA/Benzodiazepine, Sigma, NPY-Y1 /Y2 Receptors and Dopamine Transporters

2001 • 56 citations

Investigation of the Bioavailability of Hypericin, Pseudohypericin, Hyperforin and the Flavonoids Quercetin and Isorhamnetin Following Single and Multiple Oral Dosing of a Hypericum Extract Containing Tablet

2011 • 56 citations

Quercetin Potentiates <i>L</i>-Dopa Reversal of Drug-Induced Catalepsy in Rats: Possible COMT/MAO Inhibition

2003 • 51 citations

Hyperforin inhibits vesicular uptake of monoamines by dissipating pH gradient across synaptic vesicle membrane

2003 • 47 citations

Pharmacological and Endocrine Effects of Hypericum Perforatum and Hypericin After Repeated Treatment

2001 • 45 citations

Comparison of the synaptosomal uptake inhibition of serotonin by St John's wort products

2004 • 32 citations