Prostaglandins and their receptors

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

1990 • 1,896 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Comprehensive medicinal chemistry

1991 • 1,195 citations

Sequence Alignment of the G-Protein Coupled Receptor Superfamily

1992 • 847 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Advances in prostaglandin, thromboxane, and leukotriene research

1985 • 759 citations

Treatment of Primary Pulmonary Hypertension with Continuous Intravenous Prostacyclin (Epoprostenol)

1990 • 688 citations

Cloning and expression of cDNA for a human thromboxane A2 receptor

1991 • 680 citations

Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression.

1988 • 670 citations

Prostaglandin endoperoxide synthase: structure and catalysis

1991 • 607 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets

1977 • 601 citations

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

1991 • 571 citations

Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

1988 • 431 citations

Identification and Characterization of a Prostaglandin Transporter

1995 • 400 citations

MINIREVIEW: Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors

1990 • 394 citations

Cloning and expression of a cDNA for the human prostanoid FP receptor.

1994 • 386 citations

Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype.

1994 • 384 citations

Prostaglandin F2α identified as a Luteolytic Hormone in Sheep

1972 • 382 citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

1991 • 373 citations

Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.

1994 • 357 citations

Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus.

1985 • 317 citations

Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.

1993 • 305 citations

Über die Spezifische Blutdrucksenkende Substanz des Menschlichen Prostata- und Samenblasensekretes

1935 • 305 citations

A novel inhibitory prostanoid receptor in piglet saphenous vein

1994 • 273 citations

Iloprost

1992 • 254 citations

Transcription factors: a new family gathers at the cAMP response site

1990 • 244 citations

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.

1994 • 244 citations

Prevention of restenosis after percutaneous transluminal coronary angioplasty with thromboxane A2-receptor blockade. A randomized, double-blind, placebo-controlled trial. Coronary Artery Restenosis Prevention on Repeated Thromboxane-Antagonism Study (CARPORT).

1991 • 239 citations

Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene.

1994 • 226 citations

Prostaglandin E2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2R alpha gene expression at multiple levels.

1992 • 200 citations

The classification of prostaglandin DP‐receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist

1989 • 196 citations

Cloning and expression of a cDNA for the human prostanoid IP receptor.

1994 • 187 citations

Stimulation of human platelet adenylate cyclase by prostaglandin D2

1974 • 170 citations

Prostaglandin E receptor subtypes in smooth muscle: agonist activities of stable prostacyclin analogues

1986 • 167 citations

Requirement for Guanosine Triphosphate in the Prostaglandin Activation of Adenylate Cyclase of Platelet Membranes

1972 • 166 citations

A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation.

1991 • 166 citations

Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets

1989 • 154 citations

Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea‐pig ileum

1992 • 154 citations

Pharmacologic characterization of human and canine thromboxane A2/prostaglandin H2 receptors in platelets and blood vessels: evidence for different receptors.

1985 • 152 citations

Characterization of prostanoid relaxant/inhibitory receptors (ψ) using a highly selective agonist, TR4979

1986 • 149 citations

Cloning and Expression of the EP2 Subtype of Human Receptors for Prostaglandin E2

1993 • 144 citations

Prostacyclin-induced vasodilation in rabbit heart is mediated by ATP-sensitive potassium channels

1993 • 142 citations

Characterization and chromosomal mapping of the human thromboxane A2 receptor gene.

1993 • 140 citations

Two isoforms of prostaglandin E receptor EP3 subtype. Different COOH-terminal domains determine sensitivity to agonist-induced desensitization

1993 • 134 citations

Prostaglandin D2: A biochemical perspective

1989 • 133 citations

Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni

1986 • 132 citations

Regulation of cyclic AMP metabolism in rabbit cortical collecting tubule cells by prostaglandins.

1988 • 132 citations

Differentiation of Monocytoid THP-1 Cells with Phorbol Ester Induces Expression of Prostaglandin Endoperoxide Synthase-1 (COX-1)

1993 • 130 citations

Prostaglandin E₂ and the increase of intracellular cAMP inhibit the expression of interleukin 2 receptors in human T cells

1988 • 129 citations

Prostanoid inhibition of canine parietal cells: Mediation by the inhibitory guanosine triphosphate-binding protein of adenylate cyclase

1988 • 123 citations

Isoforms of the EP3 Subtype of Human Prostaglandin E2 Receptor Transduce Both Intracellular Calcium and cAMP Signals

1994 • 122 citations

Cloning and expression of three isoforms of the human EP₃ prostanoid receptor

1994 • 117 citations

Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types

1975 • 115 citations

Splice Variants of the Human EP3 Receptor for Prostaglandin E2

1995 • 111 citations

Efficiency and Side Effects of Prostaglandin El in the Treatment of Erectile Dysfunction

1988 • 111 citations

Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.

1990 • 109 citations

Prostaglandin F2α-1-Isopropylester Lowers Intraocular Pressure Without Decreasing Aqueous Humor Flow

1988 • 109 citations

Misoprostol: Discovery, development, and clinical applications

1990 • 105 citations

Purification and characterization of rabbit platelet cytosolic phospholipase A2

1991 • 103 citations

Molecular cloning and expression of human EP₃ receptors: evidence of three variants with differing carboxyl termini

1994 • 100 citations

Prostaglandin E₁and F_2αStimulate Differentiation and Proliferation, Respectively, of Clonal Osteoblastic MC3T3-E1 Cells by Different Second Messengersin Vitro*

1987 • 98 citations

Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner

1989 • 97 citations

Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites.

1993 • 94 citations

Prostaglandin-induced neurotransmission failure in the field-stimulated, isolated vas deferens

1972 • 94 citations

Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein.

1986 • 91 citations

AH6809, a prostaglandin DP‐receptor blocking drug on human platelets

1988 • 90 citations

Splice Variants of the Human EP3 Receptor for Prostaglandin E2

1995 • 89 citations

Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors

1989 • 87 citations

Vascular Smooth Muscle Actions and Receptor Interactions of 8-Iso-prostaglandin E2, an E2-Isoprostane

1993 • 84 citations

Regulation of thromboxane receptor activation in human platelets.

1989 • 81 citations

Prostaglandin E-induced heterologous desensitization of hepatic adenylate cyclase. Consequences on the guanyl nucleotide regulatory complex.

1983 • 75 citations

Cloning and Expression of the EP3-Subtype of Human Receptors for Prostaglandin E2

1994 • 75 citations

Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells

1994 • 71 citations

Prostaglandin endoperoxide/thromboxane A2 receptor desensitization. Cross-talk with adenylate cyclase in human platelets.

1990 • 71 citations

Prostaglandin F2 alpha-induced mitogenesis in MC3T3-E1 osteoblasts: role of protein kinase-C-mediated tyrosine phosphorylation.

1993 • 68 citations

A prostaglandin E receptor coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rabbit cortical collecting tubule cells.

1990 • 65 citations

Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells

1994 • 65 citations

Reconstitution of thromboxane A2 receptor-stimulated phosphoinositide hydrolysis in isolated platelet membranes: involvement of phosphoinositide-specific phospholipase C-β and GTP-binding protein Gq

1993 • 64 citations

Desensitization of adenylate cyclase in cultured fibroblasts with prostaglandin E1 and epinephrine.

1979 • 59 citations

Segregation of discrete G_sα‐mediated responses that accompany homologous or heterologous desensitization in two related somatic hybrids

1990 • 58 citations

Different pharmacologic activities for 13-azapinane thromboxane A2 analogs in platelets and blood vessels

1988 • 54 citations

Prostaglandin D2 relaxes bovine coronary arteries by endothelium-dependent nitric oxide-mediated cGMP formation.

1992 • 53 citations

Potentiation of aggregation and inhibition of adenylate cyclase in human platelets by prostaglandin E analogues

1993 • 52 citations

First Data from TD-1A

1972 • 52 citations

Prostaglandin F2αStimulates Formation of p21 -GTP Complex and Mitogen-activated Protein Kinase in NIH-3T3 Cells via Gq-protein-coupled Pathway

1995 • 50 citations

The stable prostacyclin analog, iloprost, and prostaglandin E1 inhibit monocyte procoagulant activity in vitro

1991 • 49 citations

Elevation of cytoplasmic free calcium concentration by stable thromboxane A2 analogue in human platelets

1983 • 49 citations

Prostaglandin D2 metabolite stimulates collagen synthesis by human osteoblasts during calcification

1991 • 46 citations

Interaction of prostaglandin E2 and β-adrenergic catecholamines in the regulation of uterine smooth muscle motility and adenylate cyclase in the rat

1984 • 45 citations

Beraprost Sodium

1988 • 45 citations

Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation

1993 • 43 citations

Differentiation-associated expression of prostaglandin H and thromboxane A synthases in monocytoid leukemia cell lines

1991 • 43 citations

Effect of the prostacyclin analogue iloprost on K+ permeability in the smooth muscle cells of the canine carotid artery.

1989 • 42 citations

Desensitization of prostacyclin responsiveness in a neuronal hybrid cell line: selective loss of high affinity receptors

1985 • 38 citations

Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways

1992 • 36 citations

Prostaglandin D2 reduces intraocular pressure.

1988 • 35 citations

Inhibition of Endotoxin-Induced Macrophage Tumor Necrosis Factor Expression by a Prostacyclin Analogue and Its Beneficial Effect in Experimental Lipopolysaccharide Intoxication

1992 • 30 citations

A common binding site for primary prostanoids in vascular smooth muscles: a definitive discrimination of the binding for thromboxane A2/prostaglandin H2 receptor agonist from its antagonist

1989 • 30 citations

Nocloprost, a unique prostaglandin E2 analog with local gastroprotective and ulcer-healing activity

1991 • 29 citations

Metabolism of prostaglandins D2 and F2 alpha in primary cultures of rat hepatocytes.

1986 • 29 citations

Metabolism of prostaglandins D2 and F2α in primary cultures of rat hepatocytes

1986 • 26 citations

Identification of the prostacyclin receptor by use of [15-3H1]19-(3-azidophenyl)-20-norisocarbacyclin, an irreversible specific photoaffinity probe.

1992 • 25 citations

Activation of Mitogen-Activated Protein Kinase by the Human Prostaglandin EP3A Receptor

1995 • 25 citations

The effect of GR32191 (a thromboxane receptor antagonist) on airway responsiveness in asthma

1992 • 23 citations

Cicaprost inhibits metastases of animal tumors

1991 • 20 citations

Prostaglandin F2 alpha-induced mitogenesis in MC3T3-E1 osteoblasts: role of protein kinase-C-mediated tyrosine phosphorylation

1993 • 20 citations

desensitization of a high affinity PGF2α receptor in the ovine corpus luteum

1992 • 19 citations

Zur Nomenklatur des Corpus Luteum-Hormons

1935 • 19 citations

10 Prostaglandin analogues and their uses

1992 • 15 citations

Drug-induced impairment of pulmonary [3H]prostaglandin E1 removal in vivo.

1983 • 15 citations

Prostaglandin catabolism in fetal and maternal tissues — A study of 15-hydroxyprostaglandin dehydrogenase and Δ13 reductase with specific assay methods

1989 • 11 citations

Modulation of platelet activation by prostaglandin E2 mimics.

1991 • 9 citations

[31] A receptor for prostaglandin F2α from corpora lutea

1982 • 8 citations

The role of plasmin in kinin-release by preparations of human thrombin

1979 • 7 citations

Prostaglandin E ₁ activates a chloride current in Jurkat T lymphocytes via cAMP‐dependent protein kinase

1991 • 7 citations

A multiclinic trial evaluating arbaprostil [15(R)-15-methyl prostaglandin E2] as a therapeutic agent for gastric ulcer

1989 • 5 citations

Mechanisms of action of prostaglandin E2 and prostaglandin F2α: PGE and PGFα receptors

1988 • 4 citations

A US multicenter study of enprostil 35 ?g twice daily for treatment of prepyloric, pyloric channel, and duodenal bulb ulcers

1989 • 2 citations

Desensitisation of human platelets against stimulation by thromboxane mimics--reduction in receptor capacity and loss of functional response.

1988 • 2 citations

Prostaglandins

1990 • 1 citations

Rioprostil: a clinical experience in gastric ulcer treatment.

1988 • 1 citations

Deleted Work

1955 • 0 citations