Thrombin Regulates Soluble fms-Like Tyrosine Kinase-1 (sFlt-1) Expression in First Trimester Decidua

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

2003 • 3,707 citations

Circulating angiogenic factors and the risk of preeclampsia*

2004 • 2,591 citations

Preeclampsia: An endothelial cell disorder

1989 • 1,848 citations

Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

2003 • 1,216 citations

Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?

1997 • 920 citations

The role of the spiral arteries in the pathogenesis of pre-eclampsia.

1970 • 800 citations

Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy

1983 • 720 citations

Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome

2002 • 637 citations

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

2000 • 615 citations

Overexpression of the Soluble Vascular Endothelial Growth Factor Receptor in Preeclamptic Patients: Pathophysiological Consequences

2003 • 453 citations

First Trimester Placental Growth Factor and Soluble Fms-Like Tyrosine Kinase 1 and Risk for Preeclampsia

2004 • 450 citations

Longitudinal serum concentrations of placental growth factor: Evidence for abnormal placental angiogenesis in pathologic pregnancies

2003 • 411 citations

A Vascular Endothelial Growth Factor Antagonist Is Produced by the Human Placenta and Released into the Maternal Circulation1

1998 • 408 citations

Intussusceptive angiogenesis: Its emergence, its characteristics, and its significance

2004 • 391 citations

Molecular Evidence of Placental Hypoxia in Preeclampsia

2005 • 384 citations

How strong is the association between maternal thrombophilia and adverse pregnancy outcome?

2002 • 341 citations

Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia

2005 • 337 citations

Cytotrophoblasts Up-Regulate Soluble Fms-Like Tyrosine Kinase-1 Expression under Reduced Oxygen: An Implication for the Placental Vascular Development and the Pathophysiology of Preeclampsia

2004 • 303 citations

Macrophage-Induced Apoptosis Limits Endovascular Trophoblast Invasion in the Uterine Wall of Preeclamptic Women

2001 • 295 citations

Endometrial leukocytes and menstruation

2000 • 284 citations

Tumor Necrosis Factor-α Inhibits Trophoblast Migration through Elevation of Plasminogen Activator Inhibitor-1 in First-Trimester Villous Explant Cultures

2004 • 262 citations

Threatened abortion: a risk factor for poor pregnancy outcome, a population-based screening study

2004 • 256 citations

Decidualization of the human endometrial stromal cell: an enigmatic transformation

2003 • 231 citations

Expression of the placental cytokines tumor necrosis factor α, interleukin 1β, and interleukin 10 is increased in preeclampsia

1999 • 226 citations

Is Preeclampsia More Than One Disease?

2004 • 226 citations

Preeclampsia and Future Cardiovascular Disease: Potential Role of Altered Angiogenesis and Insulin Resistance

2004 • 211 citations

Genetic Thrombophilias and Preeclampsia: A Meta-Analysis

2005 • 209 citations

Hypoxia and sFlt-1 in Preeclampsia: The “Chicken-and-Egg” Question

2004 • 193 citations

Clinical significance of subchorionic and retroplacental hematomas detected in the first trimester of pregnancy

2003 • 159 citations

Selective Overexpression of the Hypoxia-Inducible Transcription Factor, HIF-2α, in Placentas from Women with Preeclampsia1

2001 • 153 citations

Maternal thrombophilias are not associated with early pregnancy loss

2004 • 150 citations

Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia

2005 • 145 citations

Progestational regulation of human endometrial stromal cell tissue factor expression during decidualization.

1993 • 137 citations

Histologic evidence of old intrauterine bleeding is more frequent in prematurity

1995 • 136 citations

Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies

2005 • 134 citations

Regulation of Monocyte Chemoattractant Protein-1 Expression by Tumor Necrosis Factor-α and Interleukin-1β in First Trimester Human Decidual Cells

2006 • 127 citations

The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis

2004 • 123 citations

Evidence supporting that the excess of the sVEGFR-1 concentration in maternal plasma in preeclampsia has a uterine origin

2005 • 105 citations

Plasma levels of thrombin-antithrombin complexes predict preterm premature rupture of the fetal membranes

2001 • 95 citations

Plasma levels of thrombin-antithrombin complexes predict preterm premature rupture of the fetal membranes

2001 • 95 citations

Progestin regulation of plasminogen activator inhibitor type 1 in primary cultures of endometrial stromal and decidual cells.

1993 • 94 citations

Plasma markers of angiogenesis in pregnancy induced hypertension

2005 • 88 citations

An elevated maternal plasma, but not amniotic fluid, soluble fms-like tyrosine kinase-1 (sFlt-1) at the time of mid-trimester genetic amniocentesis is a risk factor for preeclampsia

2005 • 87 citations

Ovarian steroid-modulated stromelysin-1 expression in human endometrial stromal and decidual cells.

1994 • 86 citations

Clinical Significance of Subchorionic and Retroplacental Hematomas Detected in the First Trimester of Pregnancy

2003 • 81 citations

Uteroplacental Blood Flow in Pregnancy Induced Hypertension

1984 • 69 citations

Trophoblast invasion

1994 • 66 citations

Polymorphisms within the interleukin-1$beta; gene cluster and preeclampsia*1

2001 • 53 citations

Identification of genes involved in VEGF-mediated vascular morphogenesis using embryonic stem cell-derived cystic embryoid bodies

2004 • 51 citations

Vascular Endothelial Growth Factor and Placental Growth Factor Release in Cultured Trophoblast Cells Under Different Oxygen Tensions

2003 • 49 citations

Progesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture

1999 • 40 citations

Inflammatory Cytokine and Thrombin Regulation of Interleukin-8 and Intercellular Adhesion Molecule-1 Expression in First Trimester Human Decidua

2005 • 22 citations

Cardiac failure caused by severe pre-eclampsia with placental abruption, and its treatment with anti-hypertensive drugs

2003 • 13 citations