Development of human antibody fragments directed towards synaptic acetylcholinesterase using a semi-synthetic phage display library

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

By-passing immunization

1991 • 1,603 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

Canonical structures for the hypervariable regions of immunoglobulins

1987 • 1,357 citations

Acetylcholinesterase — new roles for an old actor

2001 • 1,289 citations

Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library

1996 • 1,021 citations

Solid phase peptide synthesis; a practical approach

1991 • 772 citations

A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands

1990 • 759 citations

Solid Phase Peptide Synthesis — A Practical Approach

1990 • 680 citations

The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops

1992 • 616 citations

Acute stress facilitates long-lasting changes in cholinergic gene expression

1998 • 594 citations

Antibody fragments from a ‘single pot’ phage display library as immunochemical reagents.

1994 • 578 citations

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein

1984 • 485 citations

Human anti-self antibodies with high specificity from phage display libraries.

1993 • 480 citations

By–Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling

1992 • 405 citations

Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response

1996 • 355 citations

Structural roles of acetylcholinesterase variants in biology and pathology

1999 • 353 citations

Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils

1998 • 300 citations

Targeting by affinity–matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform

1997 • 289 citations

Location of ‘continuous’ antigenic determinants in the protruding regions of proteins.

1986 • 285 citations

Proteolytic selection for protein folding using filamentous bacteriophages

1998 • 262 citations

Novel Functions of Cholinesterases in Development, Physiology and Disease

1994 • 253 citations

Neuroglial cholinesterases in the normal brain and in Alzheimer's disease: Relationship to plaques, tangles, and patterns of selective vulnerability

1993 • 218 citations

Acetylcholinesterase Enhances Neurite Growth and Synapse Development through Alternative Contributions of Its Hydrolytic Capacity, Core Protein, and Variable C Termini

1998 • 200 citations

Selection and Application of Human Single Chain Fv Antibody Fragments from a Semi-synthetic Phage Antibody Display Library with Designed CDR3 Regions

1995 • 174 citations

Transgenic expression of human acetylcholinesterase induces progressive cognitive deterioration in mice

1995 • 134 citations

Excess “read-through” acetylcholinesterase attenuates but the “synaptic” variant intensifies neurodeterioration correlates

2000 • 133 citations

Solubilization of Membrane‐Bound Acetyicholinesterase by a Phosphatidylinositol‐Specific Phospholipase C

1985 • 126 citations

[5] Screening of phage antibody libraries

1996 • 123 citations

Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis

1998 • 116 citations

Selection‐dominant and nonaccessible epitopes on cell‐surface receptors revealed by cell‐panning with a large phage antibody library

1999 • 115 citations

Global Analysis of a Macromolecular Interaction Measured on BIAcore

1996 • 103 citations

Enhanced Hemicholinium Binding and Attenuated Dendrite Branching in Cognitively Impaired Acetylcholinesterase‐Transgenic Mice

1997 • 99 citations

Treatment of alzheimer's disease with cholinesterase inhibitors

2001 • 92 citations

Expression of Three Alternative Acetylcholinesterase Messenger RNAs in Human Tumor Cell Lines of Different Tissue Origins

1994 • 88 citations

ARP, A Peptide Derived from the Stress-Associated Acetylcholinesterase Variant, Has Hematopoietic Growth Promoting Activities

2001 • 87 citations

Evidence for the direct role of acetylcholinesterase in neurite outgrowth in primary dorsal root ganglion neurons

2000 • 84 citations

The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties.

1996 • 79 citations

Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Iβ gene expression followed by late-onset neuromotor deterioration

1997 • 72 citations

Human single-chain Fv antibodies to MUC1 core peptide selected from phage display libraries recognize unique epitopes and predominantly bind adenocarcinoma.

1998 • 66 citations

Single‐chain variable fragments selected on the 57–76 p21Ras neutralising epitope from phage antibody libraries recognise the parental protein

1999 • 22 citations

Isolation of peptides from phage-displayed random peptide libraries that interact with the talin-binding domain of vinculin

1997 • 19 citations

Monoclonal antibodies against a C-terminal peptide of human brain acetylcholinesterase distinguish between erythrocyte and brain acetylcholinesterases

1996 • 9 citations