Homocysteic Acid as Transmitter Candidate in the Mammalian Brain and Excitatory Amino Acids in Epilepsy

First visualization of glutamate and GABA in neurones by immunocytochemistry

1983 • 872 citations

Organotypic monolayer cultures of nervous tissue

1981 • 862 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

Localization of serotonin in the central nervous system by immunohistochemistry: Description of a specific and sensitive technique and some applications

1978 • 535 citations

Acidic amino acids with strong excitatory actions on mammalian neurones

1963 • 415 citations

Mixed‐agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.

1984 • 274 citations

Postembedding light- and electron microscopic immunocytochemistry of amino acids: description of a new model system allowing identical conditions for specificity testing and tissue processing

1987 • 245 citations

CNS receptors: From molecular pharmacology to behavior

1983 • 218 citations

Electrophysiological mechanisms of kainic acid-induced epileptiform activity in the rat hippocampal slice

1984 • 199 citations

Effect of glutamate, aspartate and related derivatives on cerebellar Purkinje cell dendrites in the rat: an in vitro study

1982 • 198 citations

Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, papio papio

1983 • 179 citations

Cellular and synaptic basis of kainic acid-induced hippocampal epileptiform activity

1983 • 157 citations

In Vitro Release of Endogenous Excitatory Sulfur‐Containing Amino Acids from Various Rat Brain Regions

1986 • 151 citations

Glycine modulation of the NMDA receptor/channel complex

1989 • 151 citations

The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice

1987 • 136 citations

In vitro release and electrophysiological effects in situ of homocysteic acid, an endogenous N-methyl-(D)-aspartic acid agonist, in the mammalian striatum

1986 • 135 citations

Glutamate-like immunoreactivity revealed in rat olfactory bulb, hippocampus and cerebellum by monoclonal antibody and sensitive staining method

1989 • 127 citations

Postnatal development of the chemosensitivity of rat cerebellar purkinje cells to excitatory amino acids. An in vitro study

1987 • 125 citations

Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra

1984 • 124 citations

Selective retrograde labelling of the rat olivocerebellar climbing fiber system with d-[3h]aspartate

1984 • 120 citations

ACTIONS OF <scp>l</scp>‐ AND <scp>d</scp>‐HOMOCYSTEATE IN RAT CNS: A CORRELATION BETWEEN LOW‐AFFINITY UPTAKE AND THE TIME COURSES OF EXCITATION BY MICROELECTROPHORETICALLY APPLIED L‐GLUTAMATE ANALOGUES

1977 • 117 citations

Selective Amygdalo‐Hippocampectomy for Temporal Lobe Epilepsy

1988 • 108 citations

L-Homocysteic acid: An endogenous excitotoxic ligand of the NMDA receptor

1987 • 106 citations

Excitatory Amino Acid Receptor Potency and Subclass Specificity of Sulfur-Containing Amino Acids

1987 • 103 citations

Patch-clamp recording of amino acid-activated responses in "organotypic" slice cultures.

1988 • 101 citations

l-Homocysteate is a potent neurotoxin on cultured cortical neurons

1987 • 101 citations

Presurgical Evaluation of Epileptics

1987 • 97 citations

Effects of 3‐acetylpyridine on several putative neurotransmitter amino acids in the cerebellum and medulla of the rat¹

1977 • 83 citations

Pharmacological evidence for L‐aspartate as the neurotransmitter of cerebellar climbing fibres in the guinea‐pig.

1985 • 72 citations

CNS receptors : from molecular pharmacology to behavior

1983 • 71 citations

Brain regional amino acid levels in seizure susceptible rats: Changes related to sound-induced seizures

1986 • 70 citations

Reduced kainic acid binding in rat hippocampal formation after limbic kindling

1984 • 66 citations

l-Homocysteic acid but not l-glutamate is an endogenous receptor preferring agonist in rat neocortical neurons in vitro

1987 • 64 citations

Voltage clamp analysis of the effect of excitatory amino acids and derivatives on Purkinje cell dendrites in rat cerebellar slices maintained in vitro

1983 • 61 citations

Amino acid receptors and uptake systems in the mammalian central nervous system.

1988 • 61 citations

Release of Endogenous and Accumulated Exogenous Amino Acids from Slices of Normal and Climbing Fibre‐Deprived Rat Cerebellar Slices

1983 • 53 citations

Effect of Climbing Fiber Deprivation on Release of Endogenous Aspartate, Glutamate, and Homocysteate in Slices of Rat Cerebellar Hemispheres and Vermis

1990 • 51 citations

Homocysteic Acid as a Putative Excitatory Amino Acid Neurotransmitter: I. Postsynaptic Characteristics at N‐Methyl‐D‐Aspartate‐Type Receptors on Striatal Cholinergic Interneurons

1988 • 50 citations

Pharmacology of the excitatory actions of sulphonic and sulphinic amino acids.

1983 • 48 citations

Changes in cortical amino acids during electrical kindling in rats

1985 • 42 citations

The London symposia

1987 • 30 citations

Effects of ketamine and (+)cyclazocine on 4-aminopyridine and “magnesium free” epileptogenic activity in hippocampal slices of rats

1987 • 30 citations

(±)-β-Parachlorophenylglutamate selectively enhances the depolarizing response to l-homocysteic acid in neocortical neurons of the rat: evidence for a specific uptake system

1988 • 29 citations

Increased concentrations of aspartic acid in the cerebrospinal fluid of patients with epilepsy and trigeminal neuralgia: an effect of medication?

2009 • 24 citations

l-Homocysteic acid — A possible bipolar cell transmitter in the rabbit retina

1989 • 20 citations

Quisqualic acid-induced hippocampal seizures in unanesthetized cats

1985 • 20 citations

NMDA Receptor Plasticity in the Kindling Model

1990 • 16 citations

Climbing and parallel fiber responses recorded intracellularly from Purkinje cell dendrites in Guinea pig cerebellar slices

1985 • 12 citations

Pharmacological characterization of postsynaptic receptors for excitatory amino acids in purkinje cell dendrites in the guinea pig cerebellum.

1985 • 9 citations

Stereo-Electroencephalography

1987 • 6 citations

Differential Effects of Glucocorticoids on Corticotrophin‐Releasing Factor in the Rat Pituitary Neurointermediate Lobe and Median Eminence

1990 • 3 citations