Calcium, Calcium Translocation, and Specific Calcium Antagonists

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

The action of calcium on the electrical properties of squid axons

1957 • 1,853 citations

Biological Applications of Ionophores

1976 • 1,829 citations

Stimulus‐secretion coupling: the concept and clues from chromaffin and other cells

1968 • 1,393 citations

A23187: A Divalent Cation Ionophore

1972 • 1,182 citations

A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart

1883 • 941 citations

Transport and metabolism of calcium ions in nerve

1972 • 754 citations

Biological Membranes: The Physical Basis of Ion and Nonelectrolyte Selectivity

1969 • 686 citations

The ionic requirements for the production of action potentials in crustacean muscle fibres

1958 • 666 citations

Divalent Ions and the Surface Potential of Charged Phospholipid Membranes

1971 • 643 citations

Potassium activation in Helix aspersa neurones under voltage clamp: a component mediated by calcium influx.

1975 • 626 citations

Tetrodotoxin‐resistant electric activity in presynaptic terminals

1969 • 613 citations

Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors

1972 • 602 citations

The interrelationship between sodium and calcium fluxes across cell membranes

2005 • 598 citations

The electrical properties of crustacean muscle fibres

1953 • 579 citations

Calcium transport in contraction and secretion

1975 • 567 citations

Calcium in biological systems

1976 • 550 citations

Divalent cations as charge carriers in excitable membranes

1973 • 516 citations

The regulation of the calcium conductance of cardiac muscle by adrenaline.

1977 • 475 citations

Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle

1974 • 422 citations

Ionic channels in nerve membranes

1970 • 416 citations

Is calcium ionophore a universal activator for unfertilised eggs?

1974 • 388 citations

Ionic pores, gates, and gating currents

1974 • 358 citations

Tilden Lecture. The biochemistry of sodium, potassium, magnesium, and calcium

1970 • 353 citations

Intracellular calcium injection causes increased potassium conductance in Aplysia nerve cells

1972 • 349 citations

A study of the ion selectivity and the kinetic properties of the calcium dependent slow inward current in mammalian cardiac muscle.

1977 • 344 citations

Calcium Transport in Sarcoplasmic Reticulum

1975 • 328 citations

Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers.

1975 • 320 citations

Action potentials in the rat chromaffin cell and effects of acetylcholine.

1976 • 309 citations

A voltage‐sensitive persistent calcium conductance in neuronal somata of Helix.

1976 • 304 citations

Effects of manganese and other agents on the calcium uptake that follows depolarization of squid axons

1973 • 271 citations

Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium

1975 • 258 citations

Calcium couples flagellar reversal to photostimulation in Chlamydomonas reinhardtii

1976 • 255 citations

Calcium-Induced Extrusion of Secretory Granules (Exocytosis) in Mast Cells Exposed to 48/80 or the Ionophores A-23187 and X-537A

1974 • 253 citations

Relationship between internal calcium and outward current in mammalian ventricular muscle; a mechanism for the control of the action potential duration?

1976 • 250 citations

The Dynamics of Living Protoplasm

1956 • 233 citations

Effect of Verapamil on the Normal Action Potential and on a Calcium Dependent Slow Response of Canine Cardiac Purkinje Fibers

1974 • 229 citations

Ultraviolet and fluorescent spectral properties of the divalent cation ionophore A23187 and its metal ion complexes

1974 • 226 citations

Photoproteins as biological calcium indicators.

1976 • 225 citations

The Effect of Calcium Ionophores on Fragmented Sarcoplasmic Reticulum

1972 • 215 citations

Graded and All-or-None Electrogenesis in Arthropod Muscle

1961 • 214 citations

Calcium and the Heart

1971 • 214 citations

A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves.

1976 • 195 citations

Kinetics and energetics of calcium efflux from intact squid giant axons.

1976 • 194 citations

Involvement of calcium in exocytosis and the exocytosis--vesiculation sequence.

1974 • 186 citations

Inotropic and electrophysiological actions of verapamil and D600 in mammalian myocardium

1975 • 174 citations

The Action of Certain Polyvalent Cations on the Voltage-Clamped Lobster Axon

1968 • 164 citations

The activation of sea urchin eggs by the divalent ionophores A23187 and X-537A

1974 • 163 citations

Ionophore A23187: the effect of proton concentration on complex formation with divalent and monovalent cations and the demonstration of potassium(1+) ion transport in mitochondria mediated by A23187

1976 • 163 citations

Calcium Influx in Active Aplysia Neurones detected by Injected Aequorin

1973 • 160 citations

Selective inhibition of the transmembrane Ca conductivity of mammalian myocardial fibres by Ni, Co and Mn ions

1973 • 157 citations

Sodium-calcium exchange and calcium-calcium exchange in internally dialyzed squid giant axons

1975 • 147 citations

Calcium Movements and Excitation–Contraction Coupling in Cardiac Cells

1972 • 147 citations

A Regenerative Calcium Response in Paramecium

1972 • 143 citations

Active Calcium Transport and Ca2+-Activated ATPase in Human Red Cells

1975 • 142 citations

Pituitary 45 Ca ion uptake and release of ACTH, GH, and TSH: effect of verapamil

1974 • 138 citations

Calcium-antagonists and islet function

1976 • 128 citations

The lanthanide ions as structural probes in biological and model systems

2007 • 128 citations

Antibiotics and Membrane Biology

1975 • 127 citations

Human platelet secretion and aggregation induced by calcium ionophores. Inhibition by PGE1 and dibutyryl cyclic AMP.

1975 • 127 citations

Ionophore A23187, calcium and contractility in frog eggs

1974 • 125 citations

Specificity for alkali and alkaline earth cations of synthetic and natural organic complexing agents in membranes

2005 • 117 citations

On the mechanism underlying the action of D-600 on slow inward current and tension in mammalian myocardium.

1977 • 116 citations

Activation of vascular smooth muscle of rat aorta by noradrenaline and depolarization: Two different mechanisms

1971 • 115 citations

Localization of Calcium Pump Activity in Smooth Muscle

1973 • 100 citations

Regulation of Glucose Synthesis in Hormone-Sensitive Isolated Rat Hepatocytes

1973 • 100 citations

Calcium and lymphocyte activation

1976 • 100 citations

Ionic Actions on Vascular Smooth Muscle

1976 • 95 citations

Ca-dependent action potential.

1975 • 94 citations

New therapy of ischemic heart disease

1975 • 90 citations

Calcium-movement controlling cardiac contractility. II. Analog computation of cardiac excitation-contraction coupling on the basis of calcium kinetics in a multi-compartment model,

1974 • 87 citations

Influence of papaverine, D 600, and nifedipine on the effects of noradrenaline and calcium on the isolated aorta and mesenteric artery of the rabbit

1975 • 86 citations

Calcium-mediated action potentials in mammalian myocardium

1973 • 85 citations

Chemical pharmacology of the synapse

1976 • 84 citations

Kinetics of inactivation and recovery of the slow inward current in the mammalian ventricular myocardium

1975 • 83 citations

Insulin and glucagon secretion from isolated islets of Langerhans. The effects of calcium ionophores

1975 • 81 citations

The role of Ca-2+ and cyclic adenosine 3':5'-monophosphate in insulin release induced in vitro by the divalent cation ionophore A23187.

1975 • 80 citations

Evolution and Function of Calcium-Binding Proteins

1976 • 80 citations

Electrical Phenomena in the Heart

1977 • 78 citations

Calcium and stimulus‐secretion coupling in the adrenal medulla: contrasting stimulating effects of the ionophores X‐537A and A23187 on catecholamine output.

1975 • 75 citations

Possible screening of surface charges on crayfish axons by polyvalent metal ions

1973 • 75 citations

Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium

1975 • 74 citations

Lanthanum inhibits Ca inward current but not Na-Ca exchange in cardiac muscle

1973 • 74 citations

Ca2+ transport by mitochondria and its possible role in the cardiac contraction-relaxation cycle.

1974 • 74 citations

Membrane potential and contraction of vascular smooth muscle (portal vein) during application of noradrenaline and high potassium, and selective inhibitory effects of iproveratril (verapamil)

1973 • 73 citations

Effects of divalent cation ionophore A23187 on potassium permeability of rat erythrocytes.

1976 • 73 citations

Two components of the calcium current in the egg cell membrane of the tunicate.

1976 • 70 citations

THE DIFFERENT EFFECTS OF D‐600 (METHOXYVERAPAMIL) ON THE RELEASE OF ADRENAL CATECHOLAMINES INDUCED BY ACETYLCHOLINE, HIGH POTASSIUM OR SODIUM DEPRIVATION

1976 • 68 citations

Kinetics of Channel Gating in Excitable Membranes

1976 • 68 citations

Mode of Action of Chronotropic Agents in Cardiac Purkinje Fibers

1974 • 67 citations

Differentiation of Calcium Activation Mechanisms in Vascular Smooth Muscle by Selective Suppression with Verapamil and D 600

1975 • 65 citations

Na and Ca components of action potentials in amphioxus muscle cells

1971 • 64 citations

Membrane surface charge: Discrete and uniform modelling

1974 • 62 citations

Voltage-dependent changes in the permeability of nerve membranes to calcium and other divalent cations

1975 • 62 citations

Effects of Calcium on Excitable Membranes and Neurotransmitter Action

1972 • 60 citations

Manganese‐dependent propagated action potentials and their depression by electrical stimulation in guinea‐pig myocardium perfused by sodium‐free media.

1976 • 57 citations

Calcium conductance in relation to contractility in frog myocardium.

1976 • 55 citations

Calcium and sodium ions as charge carriers in the action potential of an identified snail neurone.

1975 • 52 citations

The effect of cations on the electrical properties of the smooth muscle cells of the guinea‐pig vas deferens

1967 • 50 citations

Calcium-antagonists and islet function. IV. effect of D600

1976 • 50 citations

Influence of temperature on the positive inotropic effects mediated by α- and β-adrenoceptors in the isolated rabbit papillary muscle

1975 • 48 citations

Effects of the calcium ionophore A23187 on pancreatic acinar cell membrane potentials and amylase release.

1977 • 48 citations

Preparation of Tritium-labelled Talc

1973 • 46 citations

The effect of verapamil on the response to noradrenaline or to potassium-depolarization in isolated vascular strips

1974 • 46 citations

Role of Ca2+ and Mg2+ in some human neutrophil functions as indicated by ionophore A23187

1976 • 45 citations

Calcium ionophores A23187 and X537A affect cell agglutination by lectins and capping of lymphocyte surface immunoglobulins

1976 • 44 citations

Gating Currents Associated with Sodium and Calcium Currents in an Aplysia Neuron

1976 • 44 citations

The effect of A23187 ionophore on calcium movements and contraction processes in single barnacle muscle fibres.

1976 • 43 citations

Effect of Na, metabolic inhibitors and ATP on Ca movements in L cells

1971 • 43 citations

CALCIUM AND STIMULUS-SECRETION COUPLING IN THE NEUROHYPOPHYSIS

1974 • 42 citations

Contraction of isolated smooth muscle cells by inophore A23187.

1975 • 38 citations

Interchangeability of Ca ions and Sr ions as charge carriers of the slow inward current in mammalian myocardial fibres

1973 • 37 citations

Action of D-600 on spontaneous and electrically stimulated activity of the parturient rat uterus

1975 • 36 citations

Calcium-antagonistic effects on the spontaneous activity of guinea-pig taenia coli

1974 • 34 citations

Intestinal smooth muscle contraction and the effects of cadmium and A23187.

1975 • 30 citations

Drug-Induced Changes in Cardiac Energy

2015 • 29 citations

Reversible inhibition of potassium contractures by optical isomers of verapamil and D 600 on slow muscle fibres of the frog

1976 • 27 citations

Adenosine triphosphate-dependent calcium-binding vesicles; magnesium, calcium adenosine triphosphatase and sodium, potassium adenosine triphosphatase: Distributions in dog brain

1971 • 27 citations

The Action of the Ionophores, X-537A and A-23187, on Smooth Muscle

1975 • 24 citations

Divalent cation ionophore A23187: A potent protein synthesis inhibitor

1976 • 20 citations

CALCIUM AND STIMULUS-SECRETION COUPLING IN THE NEUROHYPOPHYSIS

1974 • 20 citations

Effects of calcium ions and the bivalent cation ionophore A23187 on the agglutination and fusion of chicken erythrocytes by Sendai virus

1976 • 17 citations

THE EFFECTS OF D600 AND VERAPAMMIL ON ACTION POTENTIAL IN THE X-ORGAN NEURON OF THE CRAYFISH

1976 • 14 citations

Differentiation of Calcium Activation Systems in Vascular Smooth Muscle

1976 • 11 citations

Ca ²⁺ Transport by Mitochondria and Its Possible Role in the Cardiac Relaxation Cycle

1974 • 11 citations

On the action of nifedipine under conditions of variable stimulation patterns and [Ca2+]0 in guinea-pig atrium

1976 • 11 citations

Functional antagonism between calcium-antagonists and noradrenaline on isolated guinea-pig atria

1975 • 10 citations

Deleted Work

1955 • 0 citations