Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Defining criteria for autoimmune diseases (Witebsky's postulates revisited)

1993 • 781 citations

A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase.

1992 • 552 citations

The Molecular Basis of Allorecognition

1993 • 398 citations

The skin immune system: progress in cutaneous biology

1993 • 387 citations

Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth

1993 • 287 citations

Neuropeptides and Inflammation: The Role of Substance P

1989 • 285 citations

Evidence for Immunologic Mechanisms in Human Vitiligo: Patients' Sera Induce Damage to Human Melanocytes In Vitro by Complement-Mediated Damage and Antibody-Dependent Cellular Cytotoxicity

1988 • 211 citations

Melanocytes as "Sensory" and Regulatory Cells in the Epidermis

1993 • 156 citations

Differential Expression and Activity of Melanogenesis-Related Proteins During Induced Hair Growth in Mice

1991 • 149 citations

On the potential role of proopiomelanocortin in skin physiology and pathology

1993 • 135 citations

Immune Privilege in Hair Growth

1991 • 131 citations

Alopecia areata: alterations in the hair growth cycle and correlation with the follicular pathology

1986 • 127 citations

How the Immune System Recognizes Invaders

1993 • 125 citations

Abnormal Expression of Class I and Class II Major Histocompatibility Antigens in Alopecia Areata: Modulation by Topical Immunotherapy*

1987 • 121 citations

Incidence of Alopecia Areata in Lupus Erythematosus

1992 • 115 citations

Identification of Pigment Cell Antigens Defined by Vitiligo Antibodies

1992 • 114 citations

Topical Delivery Enhancement with Multilamellar Liposomes into Pilosebaceous Units: I. In Vitro Evaluation Using Fluorescent Techniques with the Hamster Ear Model

1992 • 113 citations

Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus

1993 • 110 citations

Cytolytic Antibodies to Melanocytes in Vitiligo

1993 • 105 citations

Pigmentation Genes: the Tyrosinase Gene Family and the pmel 17 Gene Family

1993 • 105 citations

Expression of HLA-DR by Anagen Hair Follicles in Alopecia Areata

1985 • 99 citations

Ultrastructural Observations on the Hair Bulb Melanocytes and Melanosomes in Acute Alopecia Areata

1990 • 96 citations

The DEBR rat: an animal model of human alopecia areata

1991 • 83 citations

Alopecia areata: light and electron microscopic pathology of the regrowing white hair

1984 • 82 citations

Glucocorticoid Effect on Hair Growth Initiation: A Reconsideration

1993 • 78 citations

Alopecia areata incognita: A Hypothesis

1987 • 78 citations

HLA-DR Expression by Hair Follicle Keratinocytes in Alopecia Areata: Evidence That it Is Secondary to the Lymphoid Infiltration

1988 • 71 citations

Are L-tyrosine and L-dopa hormone-like bioregulators?

1990 • 71 citations

A Biologist'S Reflections on Dermatology

1971 • 71 citations

Distribution of major histocompatibility antigens in normal skin

1983 • 69 citations

HLA-D Locus Associations in Alopecia Areata

1991 • 66 citations

Autoimmune Disease

1993 • 63 citations

HLA and ICAM-1 expression in alopecia areatain vivoandin vitro: the role of cytokines

1993 • 60 citations

Failure of passive transfer of serum from patients with alopecia areata and alopecia universalis to inhibit hair growth in transplants of human scalp skin grafted on to nude mice

1992 • 60 citations

Melanin Pigments and Melanosomal Proteins as Differentiation Markers Unique to Normal and Neoplastic Melanocytes

1993 • 57 citations

Immunohistologic and Ultrastructural Comparison of the Dermal Papilla and Hair Follicle Bulb from “Active” and “Normal” Areas of Alopecia Areata

1991 • 56 citations

Cell Degeneration in Alopecia Areata

1991 • 55 citations

DISORDERS OF THE NAILS AND HAIR ASSOCIATED WITH HUMAN IMMUNODEFICIENCY VIRUS INFECTION

1992 • 54 citations

Aberrant Intercellular Adhesion Molecule-1 (ICAM-1) Expression by Hair-Follicle Epithelial Cells and Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1) by Vascular Cells Are Important Adhesion-Molecule Alterations in Alopecia Areata

1991 • 42 citations

Phorbol-12-Myristate-13-Acetate-Treated Human Keratinocytes Express B7-Like Molecules That Serve a Costimulatory Role in T-Cell Activation

1993 • 42 citations

HLA associations with alopecia areata

1991 • 39 citations

Alopecia areata. Autoreactive T cells are variably enriched in scalp lesions relative to peripheral blood

1992 • 38 citations

Immunologic Aspects of Hair Loss

1991 • 35 citations

The psoriatic epidermal lesion and anagen hair growth may share the same "switch-on" mechanism.

1988 • 35 citations

Western blot analysis of serum antibody reactivity with human melanoma cell antigens in alopecia areata and vitiligo

1988 • 31 citations

Summary of Alopecia Areata Research Workshop and Future Research Directions

1991 • 29 citations

T-cell-directed immunointervention

1993 • 25 citations

Neuropharmacology of peptides in skin.

1988 • 18 citations

Regulated Expression of the Major Histocompatibility Complex Class I Genes

1993 • 18 citations

Alopecia areata: More on Pathogenesis and Therapy

1989 • 15 citations

Expression of extracellular matrix in hair follicle mesenchyme in alopecia areata

1990 • 11 citations